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製品番号: HY-182765

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VAV1 degrader-4

VAV1 degrader-4 is a VAV1 molecular glue degrader with a DC₅₀ value of 3.93 nM for VAV1 in Jurkat cells. VAV1 degrader-4 can dose-dependently inhibit the production of IL-2. VAV1 degrader-4 can be used for research on autoimmune diseases.

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CAS 番号: 3119457-09-6
分子式: C₂₃H₁₇ClF₂N₂O₄
分子量:458.84

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

VAV1 degrader-4 構造式

CAS 番号: 3119457-09-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

体外実験

VAV1 degrader-4 (Compound 2) (0.24-1000 nM; 24 h) shows a DC₅₀ value of 3.93 nM for VAV1 protein in Jurkat cells^[1].
VAV1 degrader-4 (72 h) dose-dependently inhibits CD3/CD28-induced IL-2 secretion from human T cells, with an IC₅₀ value of 0.53 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-t
Mice^[1]	10 mg/kg	p.o.	2970 ng/mL	37623 ng·h/mL
Rat^[1]	10 mg/kg	p.o.	15467 ng/mL	176412 ng·h/mL

体内実験

VAV1 degrader-4 (Compound 2) (10 mg/kg; p.o.; single dose) shows a C_max of 2970 ng/mL and an AUC_0-t of 37623 h·ng/mL in male ICR mice^[1].
VAV1 degrader-4 (10 mg/kg; p.o.; single dose) shows a C_max of 15467 ng/mL and an AUC_0-t of 176412 h·ng/mL in male SD rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (male; healthy)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; single dose
Result:

Showed a C_max of 2970 ng/mL and an AUC_0-t of 37623 h·ng/mL in male ICR mice.

Animal Model:

SD rats (180-240 g; male; healthy)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; single dose
Result:

Showed a C_max of 15467 ng/mL and an AUC_0-t of 176412 h·ng/mL.

化学情報

CAS 番号 3119457-09-6
分子量 458.84
分子式 C₂₃H₁₇ClF₂N₂O₄
SMILES

O=C1NC(C(CC1)C2=CC=CC(C3=CC=C(N4C=CC=C(C4=O)OC(F)F)C=C3)=C2Cl)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhang XJ, et al. VAV1 degrading agent. China, CN 121735906. 2025-09-25.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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