1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. PDGFs & PDGFRs

Platelet-derived growth factors (PDGFs) are potent mitogenic factors (mitogens) that regulate cell growth and division, in connective tissue and the developing nervous system. The PDGF family consists of five different polypeptide chains (subunits): PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. The two receptors for PDGFs are PDGFRα and PDGFRβ, which belong to receptor tyrosine kinase (RTK). PDGFRα signaling controls gastrulation and the development of the cranial, cardiac neural crest, lung, intestine, skin, kidney, skeleton, gonads, and neuroprotective tissues, whereas PDGFRβ signaling has been well established in early hematopoiesis and blood vessel formation. PDGFs participate in wound healing, regulation of blood vessel tonus, and maintenance of the interstitial fluid pressure. PDGF signaling is also involved in the pathogenesis of various proliferative diseases (certain tumors, atherosclerosis and restenosis, and fibrotic conditions).

Cat. No. Product Name / Synonyms Species Source
  • HY-P77123
    PDGF R beta Protein, Human (HEK293, C-His-Avi)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Human HEK293
    PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (HEK293, C-His-Avi) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of PDGF R beta Protein, Human (HEK293, C-His-Avi) is 498 a.a., with molecular weight of 78-115 kDa.
  • HY-P7279
    PDGF-CC Protein, Human (HEK293)

    rHuPDGF-CC; PDGF-C; SCDGF

    Human HEK293
    PDGF-CC Protein, Human (HEK293) is a member of the PDGF family, binds to PDGFR-α and PDGFR-β and acts as potent angiogenic factor.
  • HY-P7055G
    GMP PDGF-BB Protein, Human

    PDGFBB; PDGF-BB

    Human E. coli
    The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. GMP PDGF-BB Protein, Human is the recombinant human-derived PDGF-BB protein, expressed by E. coli , with tag free. The total length of GMP PDGF-BB Protein, Human is 109 a.a., with molecular weight of ~14.0 kDa.
  • HY-P72494
    PDGF R beta Protein, Human (HEK293, His)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Human HEK293
    TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDGF R beta Protein, Human (HEK293, His) is 499 a.a., with molecular weight of 85-130 kDa.
  • HY-P72495
    PDGF R alpha Protein, Human (HEK293, His)

    Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-2; CD140a; PDGFRA

    Human HEK293
    PDGF R α is a tyrosine protein kinase and an important cell surface receptor for PDGFA, PDGFB and PDGFC, affecting embryonic development, cell proliferation, survival and chemotaxis. Its effects on cell behavior vary, promoting or inhibiting proliferation and migration depending on environmental cues. PDGF R alpha Protein, Human (HEK293, His) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDGF R alpha Protein, Human (HEK293, His) is 501 a.a., with molecular weight of ~93 kDa.
  • HY-P73352
    PDGF-BB Protein, Mouse (P.pastoris, His)

    Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS

    Mouse P. pastoris
    PDGF-BB, a crucial growth factor, regulates diverse cellular processes, including development, proliferation, migration, survival, and chemotaxis. It is vital for tissue proliferation, blood vessel development, and kidney glomeruli formation. PDGF-BB interacts with PDGFRA, PDGFRB, XLKD1, LRP1, and SORL1, highlighting its versatile cellular involvement. PDGF-BB Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Mouse (P.pastoris, His) is 109 a.a., with molecular weight of ~14.2 kDa.
  • HY-P73360
    PDGF R beta Protein, Rat (HEK293, His)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Rat HEK293
    PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers. Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand. The modulation of responses involves heterodimer formation with another receptor, PDGFRB. PDGF R beta Protein, Rat (HEK293, His) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R beta Protein, Rat (HEK293, His) is 500 a.a., with molecular weight of 80-110 kDa.
  • HY-P74644
    PDGF R beta Protein, Rat (HEK293, Fc)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Rat HEK293
    PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers. Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand. The modulation of responses involves heterodimer formation with another receptor, PDGFRB. PDGF R beta Protein, Rat (HEK293, Fc) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PDGF R beta Protein, Rat (HEK293, Fc) is 499 a.a., with molecular weight of ~117 kDa.
  • HY-P7087
    PDGF-BB Protein, Mouse

    rMuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Mouse E. coli
    PDGF-BB Protein, Mouse is an active PDGF isoform, used in cell culture applications.
  • HY-P7055
    PDGF-BB Protein, Human

    rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Human E. coli
    PDGF-BB Protein, Human is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect.
  • HY-P7277
    PDGF-AA Protein, Mouse

    rMuPDGF-AA; PDGF-1; Pdgfa

    Mouse E. coli
    PDGF-AA Protein, Mouse is a member of PDGF family, binds to FDGFR, and may has the potential to enhance wound healing.
  • HY-P70825
    PDGF-AA Protein, Human (His)

    PDGFAA; PDGF-AA

    Human E. coli
    PDGF-AA Protein, Human (His) is a member of PDGF family, binds to FDGFR, and may has the potential to enhance wound healing.
  • HY-P73351
    PDGF-BB Protein, Human (P.pastoris, His)

    Platelet-derived growth factor subunit B; PDGF subunit B; PDGF2; PDGFB; SIS

    Human P. pastoris
    The PDGF-BB protein is a key growth factor that centrally regulates embryonic development, cell proliferation, migration, survival, and chemotaxis. It is known for its potent mitogenic effects on mesenchymal cells and is essential for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in tissues such as the central nervous system, skin, lungs, heart, and placenta. PDGF-BB Protein, Human (P.pastoris, His) is the recombinant human-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Human (P.pastoris, His) is 109 a.a., with molecular weight of ~14.3 kDa.
  • HY-P7055A
    PDGF-BB Protein, Human (P.pastoris)

    rHuPDGF-BB; PDGF-2; GDGF; ODGF; SIS; SSV

    Human P. pastoris
    PDGF-BB Protein, Human (P.pastoris) is the most active PDGF isoform, binds to PDGF receptor, promotes diverse cell types proliferation and osteogenesis, and further stimulates bone formation in fracture or defect.
  • HY-P70598
    PDGF-AA Protein, Human

    PDGFAA; PDGF-AA

    Human E. coli
    PDGF-A protein is a key growth factor that regulates embryonic development, cell proliferation, migration, survival, and chemotaxis, and exerts potent mitogenic effects on mesenchymal cells. It is essential for alveolar septal formation, gastrointestinal tract development, interstitial cell maturation, spermatogenesis, and oligodendrocyte development, and contributes to spinal cord and cerebellar myelination. PDGF-AA Protein, Human is the recombinant human-derived PDGF-AA protein, expressed by E. coli , with tag free. The total length of PDGF-AA Protein, Human is 125 a.a., with molecular weight of ~16.0 kDa.
  • HY-P73354
    PDGF-CC Protein, Mouse (HEK293, Fc)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Mouse HEK293
    The PDGF-CC protein is a key growth factor that plays crucial roles in a variety of cellular processes, including embryonic development, cell proliferation, migration, survival, and chemotaxis. It has potent mitogenic and chemoattractant properties and is essential during embryonic skeletal formation, craniofacial development, palate development, skin morphogenesis and wound healing stages. PDGF-CC Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PDGF-CC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of PDGF-CC Protein, Mouse (HEK293, Fc) is 111 a.a., with molecular weight of ~46 kDa.
  • HY-P74640
    PDGF-CC Protein, Cynomolgus (HEK293, hFc)

    PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF

    Cynomolgus HEK293
    Platelet derived growth factor C (PDGF-CC) is a growth factor that plays an essential role in the regulation of cell proliferation, cell migration, survival and chemotaxis. PDGF-CC is a potent mitogen and chemoattractant for cells of mesenchymal origin which plays an important roll in normal skeleton formation and normal skin morphogenesis during embryonic development, wound healing, angiogenesis and blood vessel development as well as being involved in fibrotic processes. PDGF-CC Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived PDGF-CC protein, expressed by HEK293 , with N-hFc labeled tag. The total length of PDGF-CC Protein, Cynomolgus (HEK293, hFc) is 111 a.a., with molecular weight of ~45 kDa.
  • HY-P74643
    PDGF-AA Protein, Human (P.pastoris, His)

    Platelet-derived growth factor subunit A; PDGF-1; PDGFA

    Human P. pastoris
    PDGF-A protein is a key growth factor that regulates embryonic development, cell proliferation, migration, survival, and chemotaxis, and exerts potent mitogenic effects on mesenchymal cells. It is essential for alveolar septal formation, gastrointestinal tract development, interstitial cell maturation, spermatogenesis, and oligodendrocyte development, and contributes to spinal cord and cerebellar myelination. PDGF-AA Protein, Human (P.pastoris, His) is the recombinant human-derived PDGF-AA protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-AA Protein, Human (P.pastoris, His) is 125 a.a., with molecular weight of ~16.3 kDa.
  • HY-P75966
    PDGF-BB Protein, Cynomolgus (HEK293, Fc)

    Platelet-derived growth factor subunit B; PDGF-2; PDGFB

    Cynomolgus HEK293
    PDGF-BB is a growth factor frequently overexpressed in cancers, are novel potent lymphangiogenic factors. PDGF-BB Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived PDGF-BB protein, expressed by HEK293 , with N-mFc labeled tag. The total length of PDGF-BB Protein, Cynomolgus (HEK293, Fc) is 109 a.a., with molecular weight of ~43 & 32 kDa, respectively.
  • HY-P77129
    PDGF R beta Protein, Rhesus Macaque (HEK293, His)

    Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB

    Rhesus Macaque HEK293
    PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag. The total length of PDGF R beta Protein, Rhesus Macaque (HEK293, His) is 498 a.a., with molecular weight of ~80-96 KDa.
Cat. No. Product Name Effect Purity