PDGF-BB Protein, Mouse (P.pastoris, His)

PDGF-BB, a crucial growth factor, assumes a central role in regulating diverse cellular processes, encompassing embryonic development, cell proliferation, migration, survival, and chemotaxis. As a potent mitogen for mesenchymal cells, PDGF-BB is indispensable for the normal proliferation and recruitment of pericytes and vascular smooth muscle cells in various tissues, including the central nervous system, skin, lung, heart, and placenta. It is essential for blood vessel development and the formation of kidney glomeruli, highlighting its multifaceted contributions to tissue homeostasis. Furthermore, PDGF-BB plays a pivotal role in wound healing. The intricacies of its signaling are modulated by the formation of antiparallel homodimers, linked by disulfide bonds, and antiparallel heterodimers with PDGFA. These dynamic dimers engage in intricate interactions with PDGFRA and PDGFRB homodimers, as well as heterodimers formed by PDGFRA and PDGFRB. Additionally, PDGF-BB interacts with XLKD1, LRP1, and SORL1, further emphasizing its versatile involvement in cellular regulation.