Pdgfb - platelet derived growth factor, B polypeptide Gene

Also Known as Sis; c-sis; PDGF-2; PDGF-B

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18591

Summary

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue Cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfb Products (3)

mRNA Protein Name
NM_001411619.1 NP_001398548.1 platelet-derived growth factor subunit B isoform 2
NM_001411620.1 NP_001398549.1 platelet-derived growth factor subunit B isoform 2
NM_011057.5 NP_035187.2 platelet-derived growth factor subunit B isoform 1 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
12176888 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
16456542 MGI
involved in blood vessel development IEP
IEP: Inferred from expression pattern
10375497 MGI
acts upstream of or within blood vessel morphogenesis IDA
IDA: Inferred from direct assay
15919073 MGI
acts upstream of or within blood vessel morphogenesis IGI
IGI: Inferred from genetic interaction
15919073 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
18559345 MGI
acts upstream of cell migration IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of or within cell projection assembly IDA
IDA: Inferred from direct assay
12176888 MGI
involved in cellular response to platelet-derived growth factor stimulus IDA
IDA: Inferred from direct assay
28867608 MGI
involved in embryonic placenta development IMP
IMP: Inferred from mutant phenotype
15084468 MGI
acts upstream of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
18559345 MGI
acts upstream of or within eye photoreceptor cell development IMP
IMP: Inferred from mutant phenotype
25224828 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
18559345 MGI
acts upstream of or within fibroblast migration IDA
IDA: Inferred from direct assay
15183724 MGI
acts upstream of fibroblast migration IGI
IGI: Inferred from genetic interaction
16456542 MGI
acts upstream of or within glial cell development IMP
IMP: Inferred from mutant phenotype
25224828 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
15084468 MGI
involved in metanephric glomerular endothelium development IEP
IEP: Inferred from expression pattern
9693135 MGI
involved in metanephric glomerular mesangial cell development IMP
IMP: Inferred from mutant phenotype
15084468 MGI
involved in metanephric glomerular mesangial cell proliferation involved in metanephros development IMP
IMP: Inferred from mutant phenotype
9693135 MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of or within neuron remodeling IMP
IMP: Inferred from mutant phenotype
25224828 MGI
involved in paracrine signaling IMP
IMP: Inferred from mutant phenotype
15084468 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
16456542 MGI
acts upstream of or within positive regulation of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
18559345 MGI
acts upstream of or within positive regulation of fibroblast migration IGI
IGI: Inferred from genetic interaction
16456542 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
28867608 MGI
involved in positive regulation of glomerular filtration IMP
IMP: Inferred from mutant phenotype
15084468 MGI
acts upstream of or within positive regulation of mitotic cell cycle, embryonic IGI
IGI: Inferred from genetic interaction
18827006 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
16456542 MGI
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
10375497 MGI
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
28867608 MGI
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
10375497 MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell proliferation IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
11940581 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
25224828 MGI
acts upstream of or within retina vasculature development in camera-type eye IMP
IMP: Inferred from mutant phenotype
25224828 MGI
acts upstream of or within substrate-dependent cell migration IDA
IDA: Inferred from direct assay
15183724 MGI
acts upstream of or within synapse assembly IMP
IMP: Inferred from mutant phenotype
25224828 MGI
acts upstream of vascular associated smooth muscle cell migration IGI
IGI: Inferred from genetic interaction
16644864 MGI
acts upstream of vascular associated smooth muscle cell proliferation IGI
IGI: Inferred from genetic interaction
16644864 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet-derived growth factor subunit B

  • PDGF subunit B

  • platelet-derived growth factor B chain

  • platelet-derived growth factor beta polypeptide

  • proto-oncogene c-Sis

Recombinant Pdgfb Proteins

Cat. No. Product Name Accession Purity
HY-P7087 PDGF-BB Protein, Mouse P31240 (S82-T190) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70699 PDGF-BB Protein, Mouse (His) AAH53430.1 (S82-T190) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73352 PDGF-BB Protein, Mouse (P.pastoris, His) AAH23427.1 (S60-T168) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991724 Vasigrobart Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159059 Ganoderma lucidum polysaccharide 41.20% Unkown
HY-160047 AX102 sodium 98.15% Unkown
HY-RS17147 Pdgfb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160048 PEG40K unconjugated/naked AX102 sodium / Unkown
HY-RS10251 PDGFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174552 Human PDGFB mRNA / Unkown
HY-RS23596 Pdgfb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdgfb NCBI NCBI:5155