2. Apoptosis Cell Cycle/DNA Damage Stem Cell/Wnt Metabolic Enzyme/Protease Immunology/Inflammation
  3. c-Myc Bcl-2 Family Eukaryotic Initiation Factor (eIF) Survivin β-catenin MMP Interleukin Related
  4. Ganoderma Lucidum/Reishi Extract

Ganoderma Lucidum/Reishi Extract is a Ganoderma lucidum extract. Ganoderma Lucidum/Reishi Extract reduces the expression of c-Myc, BCL-2, BCL-XL, TERT, PDGFB, eIF4G, Survivin, β-catenin, and eIF4E. Ganoderma Lucidum/Reishi Extract downregulates the gene expression of MMP-9. Ganoderma Lucidum/Reishi Extract upregulates the expression of IL8. Ganoderma Lucidum/Reishi Extract is applicable to the research of inflammatory breast cancer. Ganoderma Lucidum is used in the research of various diseases, such as allergy, arthritis, hypertension, neurasthenia, inflammation, and cancer.

For research use only. We do not sell to patients.

Ganoderma Lucidum/Reishi Extract

Ganoderma Lucidum/Reishi Extract Chemical Structure

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Ganoderma Lucidum/Reishi Extract Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

Ganoderma Lucidum/Reishi Extract is a Ganoderma lucidum extract. Ganoderma Lucidum/Reishi Extract reduces the expression of c-Myc, BCL-2, BCL-XL, TERT, PDGFB, eIF4G, Survivin, β-catenin, and eIF4E. Ganoderma Lucidum/Reishi Extract downregulates the gene expression of MMP-9. Ganoderma Lucidum/Reishi Extract upregulates the expression of IL8. Ganoderma Lucidum/Reishi Extract is applicable to the research of inflammatory breast cancer. Ganoderma Lucidum is used in the research of various diseases, such as allergy, arthritis, hypertension, neurasthenia, inflammation, and cancer[1][2].

IC50 & Target[1]

MMP-9

 

IL-8

 

eIF4G

 

eIF4E

 

Bcl-xL

 

Bcl-2

 

In Vitro

Ganoderma Lucidum/Reishi Extract (0.05-1.0 mg/mL; 24-96 h) selectively inhibits viability across multiple cancer cell lines, including SUM-149 IBC cells (with 50% inhibition at 0.25 mg/mL over 96 hours), while causing minimal viability reduction in noncancerous MCF10A mammary epithelial cells[1].
Ganoderma Lucidum/Reishi Extract (0.5 mg/mL; 24 h) induces apoptosis in ~90% of SUM-149 IBC cells after 24-hour treatment with 0.5 mg/mL[1].
Ganoderma Lucidum/Reishi Extract (0.5 mg/mL; 24 h) inhibits invasion of SUM-149 IBC cells by 80% after 24-hour treatment with 0.5 mg/mL[1].
Ganoderma Lucidum/Reishi Extract (0.5 mg/mL; 48 h) disrupts tumor spheroid formation in SUM-149 IBC cells after 48-hour treatment with 0.5 mg/mL[1].
Ganoderma Lucidum/Reishi Extract (0.5 mg/mL; 24 h) reduces MMP-2 and MMP-9 gelatinase activity by ~50% in SUM-149 IBC cells after 24-hour treatment with 0.5 mg/mL[1].
Ganoderma Lucidum/Reishi Extract (0.5 mg/mL; 24 h) reduces expression of key survival, adhesion, and translation-related proteins (including BCL-2, E-cadherin, eIF4G, c-Myc) in SUM-149 IBC cells after 24-hour treatment with 0.5 mg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ganoderma Lucidum/Reishi Extract Related Antibodies

Cell Viability Assay[1]

Cell Line: SUM-149 inflammatory breast cancer (IBC) cells, MCF10A noncancerous mammary epithelial cells, MDA-MB-468 breast cancer cells, MDA-MB-435 breast cancer cells, A-172 glioma cells, MiaPaCa pancreatic cancer cells
Concentration: 0.5-1.0 mg/mL (24 h incubation for all cell lines); 0.05-1.0 mg/mL (96 h incubation with dosing every 48 h for SUM-149 cells)
Incubation Time: 24 h (all cell lines); 96 h (SUM-149 cells with dosing every 48 h)
Result: Reduced SUM-149 viability by 67% at 0.5 mg/mL and 98% at 1.0 mg/mL after 24 h.
Left MCF10A viability unchanged at 0.5 mg/mL and reduced it by 11% at 1.0 mg/mL after 24 h.
Reduced MDA-MB-468 viability by 31% at 0.5 mg/mL and an additional 45% at 1.0 mg/mL after 24 h.
Reduced MDA-MB-435 viability by 60% at 0.5 mg/mL and an additional 91% at 1.0 mg/mL after 24 h.
Reduced A-172 viability by 31% at 0.5 mg/mL and an additional 49% at 1.0 mg/mL after 24 h.
Reduced MiaPaCa viability by 41% at 0.5 mg/mL with no additional effect at 1.0 mg/mL after 24 h.
Increased SUM-149 viability by 14% at 0.05 mg/mL, reduced viability by 50% at 0.25 mg/mL, 82% at 0.5 mg/mL, and 90% at 1.0 mg/mL after 96 h.
Achieved 50% inhibition of SUM-149 viability at 0.25 mg/mL over 96 h.

Cell Invasion Assay[1]

Cell Line: SUM-149 IBC cells
Concentration: 0.5 mg/mL
Incubation Time: 24 h
Result: Impaired SUM-149 cell invasion into the Matrigel matrix by 80% compared to controls.

Real Time qPCR[1]

Cell Line: SUM-149 IBC cells
Concentration: 0.5 mg/mL
Incubation Time: 8 h
Result: Downregulated BCL2, CDKN2A, FGFR2, PDGFB, TERT, and MMP9.
Upregulated IL8.

Western Blot Analysis[1]

Cell Line: SUM-149 IBC cells
Concentration: 0.5 mg/mL
Incubation Time: 24 h
Result: Reduced protein expression of BCL-2 (1.6-fold), BCL-XL (1.9-fold), survivin (1.3-fold), E-cadherin (1.7-fold), beta-catenin (1.3-fold), c-Myc (2-fold), p120-catenin (3-fold), eIF4G (2.2-fold), and eIF4E (1.3-fold) compared to controls.
Appearance

Solid

Color

Brown to orange

SMILES

[Ganoderma Lucidum/Reishi Extract]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 4 mg/mL (ultrasonic and warming and heat to 60°C)

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Purity & Documentation

Purity: 41.20%

SDS (251 KB)

COA (240 KB)

Handling Instructions (2659 KB)
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Ganoderma Lucidum/Reishi Extract Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganoderma Lucidum/Reishi Extractc-MycBcl-2 FamilyEukaryotic Initiation Factor (eIF)Survivinβ-cateninMMPInterleukin RelatedMycBeta cateninMatrix metalloproteinasesILMCF-7 cellsVero cellsinflammatory breast cancerMCF10A mammary epithelial cellsHL-60 leukemia cellsU937 leukemia cellsMT-4 cellsHeLa cellsSUM-149 IBC cellsPC12 neuronal cellsInhibitorinhibitorinhibit

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