1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family
  4. Mcl-1 Isoform

Mcl-1

 

Mcl-1 Related Products (39):

Cat. No. Product Name Effect Purity
  • HY-100741
    S63845
    Inhibitor 99.94%
    S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1.
  • HY-50907
    ABT-737
    Inhibitor 99.59%
    ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively.
  • HY-19741
    A-1331852
    Inhibitor 99.65%
    A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
  • HY-101533
    AZD-5991
    Inhibitor 99.50%
    AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay.
  • HY-114855
    BT2
    Inhibitor 99.56%
    BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM.
  • HY-19551
    Apogossypolone
    Inhibitor
    Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively.
  • HY-150507
    JNJ-4355
    Inhibitor
    JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM.
  • HY-112218
    MIK665
    Inhibitor 99.72%
    MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor.
  • HY-10969
    Obatoclax Mesylate
    Inhibitor 99.74%
    Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2.
  • HY-101565
    Tapotoclax
    Inhibitor 99.80%
    Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM.
  • HY-12468
    A-1210477
    Inhibitor 98.89%
    A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM.
  • HY-N0087
    Gambogic Acid
    Inhibitor 98.85%
    Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi.
  • HY-15464A
    (R)-(-)-Gossypol acetic acid
    Inhibitor 98.02%
    (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol.
  • HY-125877
    PROTAC Mcl1 degrader-1
    Inhibitor 98.13%
    PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM.
  • HY-12020
    TW-37
    Inhibitor 99.27%
    TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
  • HY-125876
    PROTAC Bcl2 degrader-1
    Inhibitor 98.78%
    PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
  • HY-112859
    VU0661013
    Inhibitor 98.52%
    VU661013 is a potent and selective MCL-1 inhibitor.
  • HY-15613
    Maritoclax
    Inhibitor 99.97%
    Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).
  • HY-15191
    Sabutoclax
    Inhibitor
    Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.
  • HY-16695
    MIM1
    Inhibitor ≥98.0%
    MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).