1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family
  4. Mcl-1 Inhibitors

Mcl-1 Inhibitors

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform Mcl-1 together.

Please try each isoform separately.

Mcl-1 Specific Inhibitors
Product Name Mcl-1 Bcl-2 Bcl-xL Bcl-W Bfl-1 Bcl-B Bim Mcl-1 Selectivity Purity
S63845
MCL1, Kd: 0.19 nM
            Selective Inhibitor 99.94%
AZD-5991
Mcl-1, IC50: 0.7 nM
Mcl-1, Kd: 0.17 nM
            Selective Inhibitor 99.50%
AMG-176
Mcl-1, Ki: 0.13 nM
            Selective Inhibitor 99.53%
A-1210477
Mcl-1, Ki: 0.45 nM
Bcl-2, Ki: 132 nM
 
Bcl-W, Ki: 2280 nM
Bfl-1, Ki: 660 nM
    Selective Inhibitor 98.89%
MIK665
Mcl-1, IC50: 1.81 nM
            Selective Inhibitor 98.81%
BT2
Mcl-1, Ki: 59 μM
            Selective Inhibitor 98.10%
Maritoclax
Mcl-1, IC50: 10.1 μM
            Selective Inhibitor 99.97%
MIM1
Mcl-1
            Selective Inhibitor >98.0%
PROTAC Mcl1 degrader-1
Mcl-1, IC50: 0.78 μM
            Selective Inhibitor 98.13%
VU0661013
Mcl-1
            Selective Inhibitor 98.42%
Mcl1-IN-8
Mcl-1, Ki: 0.3 μM
            Selective Inhibitor >98.0%
Mcl1-IN-1
Mcl-1, IC50: 2.4 μM
            Selective Inhibitor 98.40%
Mcl1-IN-2
Mcl-1
            Selective Inhibitor >95.0%
Pyridoclax
Mcl-1
            Selective Inhibitor 99.74%
A-1331852
Mcl-1, Ki: 142 nM
Bcl-2, Ki: 6 nM
Bcl-xL, Ki: 0.01 nM
Bcl-W, Ki: 4 nM
      Pan Inhibitor 99.81%
Obatoclax Mesylate
Mcl-1, Ki: 1-7 μM
Bcl-2, Ki: 220 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
  Pan Inhibitor 99.74%
Gambogic Acid
Mcl-1, IC50: 0.79 μM
Bcl-2, IC50: 1.21 μM
Bcl-xL, IC50: 1.47 μM
Bcl-W, IC50: 2.02 μM
Bfl-1, IC50: 1.06 μM
Bcl-B, IC50: 0.66 μM
  Pan Inhibitor 95.06%
TW-37
Mcl-1, Ki: 260 nM
Bcl-2, Ki: 290 nM
Bcl-xL, Ki: 1110 nM
        Pan Inhibitor 98.50%
PROTAC Bcl2 degrader-1
Mcl-1, IC50: 11.81 μM
Bcl-2, DC50: 3 μM
Bcl-2, IC50: 4.94 μM
          Pan Inhibitor 98.28%
(R)-(-)-Gossypol acetic acid
Mcl-1, Ki: 170 nM
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
        Pan Inhibitor 97.40%
(R)-(-)-Gossypol
Mcl-1, Ki: 170 nM
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
        Pan Inhibitor
Sabutoclax
Mcl-1, IC50: 0.2 μM
BCL2, IC50: 0.32 μM
Bcl-xL, IC50: 0.31 μM
 
Bfl-1, IC50: 0.62 μM
    Pan Inhibitor
Obatoclax
Mcl-1, Ki: 1-7 μM
BCL2, Ki: 200 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
  Pan Inhibitor
MCL-1/BCL-2-IN-1
Mcl-1, IC50: 4.45 μM
Bcl-2, IC50: 3.18 μM
          Pan Inhibitor 98.04%
(+)-Apogossypol
Mcl-1, EC50: 2.6 μM
Bcl-2, EC50: 2.8 μM
Bcl-xL, EC50: 3.69 μM
        Pan Inhibitor
ML311
Mcl-1
         
Bim
default Inhibitor 98.04%