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PROTAC Mcl1 degrader-1 

Cat. No.: HY-125877
Handling Instructions

PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity.

For research use only. We do not sell to patients.

PROTAC Mcl1 degrader-1 Chemical Structure

PROTAC Mcl1 degrader-1 Chemical Structure

CAS No. : 2163793-38-0

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Description

PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity[1].

IC50 & Target[1]

Mcl-1

0.78 μM (IC50)

Molecular Weight

909.84

Formula

C₄₅H₄₅BrN₆O₈S

CAS No.

2163793-38-0

SMILES

O=C(C1=CC=CC(NCCCCCCNC(CCCCC(NCCN2C(C3=C4C(C2=O)=CC=C(C4=CC=C3)SC5=CC=C(C=C5)Br)=O)=O)=O)=C1C6=O)N6C7CCC(NC7=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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PROTAC Mcl1 degrader-1
Cat. No.:
HY-125877
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