1. PROTAC
    Apoptosis
  2. PROTAC
    Bcl-2 Family
  3. PROTAC Bcl2 degrader-1

PROTAC Bcl2 degrader-1 

Cat. No.: HY-125876
Handling Instructions

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.

For research use only. We do not sell to patients.

PROTAC Bcl2 degrader-1 Chemical Structure

PROTAC Bcl2 degrader-1 Chemical Structure

CAS No. : 2378801-85-3

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Description

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1].

IC50 & Target[1]

Bcl-2

3 μM (DC50)

Bcl-2

4.94 μM (IC50)

Mcl-1

11.81 μM (IC50)

Molecular Weight

941.84

Formula

C₄₅H₄₅BrN₆O₁₀S

CAS No.

2378801-85-3

SMILES

O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PROTAC Bcl2 degrader-1
Cat. No.:
HY-125876
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