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  3. PROTAC Bcl2 degrader-1

PROTAC Bcl2 degrader-1 

Cat. No.: HY-125876 Purity: 98.28%
Handling Instructions

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.

For research use only. We do not sell to patients.

PROTAC Bcl2 degrader-1 Chemical Structure

PROTAC Bcl2 degrader-1 Chemical Structure

CAS No. : 2378801-85-3

Size Price Stock Quantity
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Description

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1].

IC50 & Target[1]

Bcl-2

3 μM (DC50)

Bcl-2

4.94 μM (IC50)

Mcl-1

11.81 μM (IC50)

Molecular Weight

941.84

Formula

C₄₅H₄₅BrN₆O₁₀S

CAS No.

2378801-85-3

SMILES

O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (26.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0618 mL 5.3088 mL 10.6175 mL
5 mM 0.2124 mL 1.0618 mL 2.1235 mL
10 mM 0.1062 mL 0.5309 mL 1.0618 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PROTAC Bcl2 degrader-1PROTACBcl-2 FamilyProteolysis-targeting chimeraInhibitorinhibitorinhibit

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Product Name:
PROTAC Bcl2 degrader-1
Cat. No.:
HY-125876
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