2378801-85-3
Chemical Structure
PROTAC Bcl2 degrader-1
- CAS No.: 2378801-85-3
- Formula:C45H45BrN6O10S
- Molecular Weight:941.84
IUPAC Name: N1-(2-(6-((4-bromophenyl)thio)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl)-N6-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)adipamide
InChIKey: IUSLKFLLLNNOGR-UHFFFAOYSA-N
SMILES: O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O
Biological Activity: PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PROTAC Bcl2 degrader-1 | 99.80% | PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. | ||||||||||||||||||||
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Similarity Score 0.90
HY-125877PROTAC Mcl1 degrader-1 -
Similarity Score 0.62
HY-134850QC-01–175 -
Similarity Score 0.62
HY-111594Homo-PROTAC cereblon degrader 1 -
Similarity Score 0.61
HY-161597PROTAC DYRK2 degrader 1 -
Similarity Score 0.61
HY-186287PROTAC DYRK2 degrader-2 -
Similarity Score 0.60
HY-168593PROTAC KDM3 degrader-1 -
Similarity Score 0.60
HY-176740PROTAC Bcl-xL degrader-4 -
Similarity Score 0.59
HY-125883Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc -
Similarity Score 0.59
HY-149678PROTAC eDHFR Degrader-1 -
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