PROTAC Bcl-xL degrader-4
PROTAC Bcl-xL degrader-4 (Compound 2-38-III) is a Bcl-xL PROTAC degrader. PROTAC Bcl-xL degrader-4 has strong anti-tumor activity against HepG2 cells and HUVEC cells. PROTAC Bcl-xL degrader-4 induces cells apoptosis by decreasing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTAC Bcl-xL degrader-4 significantly inhibits tumor growth in xenograft tumor mouse models.
(Pink: Bcl-xL ligand (HY-176741); Blue: Cereblon ligand (HY-W924948); Black: linker (HY-W017440)).
For research use only. We do not sell to patients.
- CAS No.: 2930759-37-6
- Formula: C39H34N4O9
- Molecular Weight:702.71
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
|
Bcl-2 |
Bcl-xL |
Chemical Information
-
CAS No. 2930759-37-6
-
Molecular Weight 702.71
-
Formula C39H34N4O9
-
SMILES
O=C1N(C(C2=CC=CC(NCCOCCOCCOC(C3=CC4=C(NC(C5=CC=CC6=C5C=CC=C6)=CC4=O)C=C3)=O)=C21)=O)C7CCC(NC7=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC Bcl-xL degrader-4 Related Classifications
HY-176740 Related Classifications
Powered by Bioz