2930759-37-6
Chemical Structure
PROTAC Bcl-xL degrader-4
- CAS No.: 2930759-37-6
- Formula:C39H34N4O9
- Molecular Weight:702.71
InChIKey: MIEJPLAPORKYSG-UHFFFAOYSA-N
SMILES: O=C1N(C(C2=CC=CC(NCCOCCOCCOC(C3=CC4=C(NC(C5=CC=CC6=C5C=CC=C6)=CC4=O)C=C3)=O)=C21)=O)C7CCC(NC7=O)=O
Biological Activity: PROTAC Bcl-xL degrader-4 (Compound 2-38-III) is a Bcl-xL PROTAC degrader. PROTAC Bcl-xL degrader-4 has strong anti-tumor activity against HepG2 cells and HUVEC cells. PROTAC Bcl-xL degrader-4 induces cells apoptosis by decreasing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTAC Bcl-xL degrader-4 significantly inhibits tumor growth in xenograft tumor mouse models[1].
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PROTAC Bcl-xL degrader-4 | PROTAC Bcl-xL degrader-4 (Compound 2-38-III) is a Bcl-xL PROTAC degrader. PROTAC Bcl-xL degrader-4 has strong anti-tumor activity against HepG2 cells and HUVEC cells. PROTAC Bcl-xL degrader-4 induces cells apoptosis by decreasing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTAC Bcl-xL degrader-4 significantly inhibits tumor growth in xenograft tumor mouse models. | |||||||||||||||||||||
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Keywords
