Cat. No.: HY-L058

Glycolysis Compound Library

86 Cited Publications

Customer Review

Based on 86 publication(s) in Google Scholar

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 1,335 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (86)
Documentation
Composition

Description & Advantages

• A unique collection of 1,335 glycolysis-related small molecules for high throughput screening (HTS) and high content screening (HCS).

• Targets such as hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc.

• A useful tool for glucose metabolism research and anti-cancer drug discovery.

• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

• Structurally diverse, medicinally active, and cell permeable.

• More detailed compound information with structure, IC₅₀, and brief introduction.

• NMR and HPLC validated to ensure high purity and quality.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 1,335 glycolysis compounds supplied as pre-dissolved Solutions or Solid

Solution: 1,281 compounds supplied in 10 mM solution, 49 compounds supplied in 2 mM solution, 5 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice