1. Signaling Pathways
  2. Anti-infection
  3. Filovirus

Filovirus

Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates. The family Filoviridae includes two genera: Marburgvirus, comprising various strains of the Lake Victoria marburgvirus (MARV); and Ebolavirus (EBOVs), comprising four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV); and a tentative species Bundibugyo ebolavirus (BEBOV).

The infections typically affect multiple organs in the body and are often accompanied by hemorrhage (bleeding). Once the virus has been transmitted from an animal host to a human, it can then spread through person-to-person contact.

Filovirus Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-10221
    Vorinostat Inhibitor 99.90%
    Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.
  • HY-18649A
    Galidesivir Inhibitor 99.29%
    Galidesivir (BCX4430) is a viral RNA-dependent RNA polymerase (RdRp) inhibitor. Galidesivir inhibits SARS-CoV-2 by tightly bindind to its RdRp.
  • HY-18649
    Galidesivir hydrochloride Inhibitor 99.88%
    Galidesivir hydrochloride (BCX 4430 hydrochloride) is a viral RNA-dependent RNA polymerase (RdRp) inhibitor. Galidesivir hydrochloride inhibits SARS-CoV-2 by tightly bindind to its RdRp.
  • HY-113794
    DSHS00884 Inhibitor 98.24%
    DSHS00884 is a potent human papillomavirus E6 inhibitor with an IC50 of 10 μM.
  • HY-13516
    Aloperine Inhibitor >98.0%
    Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.
  • HY-N4118
    Cephaeline Inhibitor >98.0%
    Cephaeline is a phenolic alkaloid in Indian Ipecac roots. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections.
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