Maftivimab
Based on 1 Customer Validation
Maftivimab (REGN3470-3471-3479) is a human monoclonal antibody targeting the glycoprotein of Zaire ebolavirus (ZEBOV), with an IC50 of 0.17 nM and a Kd of 2.97 nM. Maftivimab is applicable to research related to Zaire ebolavirus infection and Ebola virus disease.
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- Purity: 96.89%
- CAS No.: 2135632-36-7
- 분자량:143.94 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Virus
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ZEBOV 2.97 nM (Kd) |
ZEBOV 0.17 nM (IC50) |
Maftivimab binds with high affinity to the recombinant histidine-tagged extracellular domain protein of Ebola virus Makona strain glycoprotein (Kd = 2.97 × 10 nM[1]).
Maftivimab potently neutralizes Ebola pseudovirus particles in vitro, with an IC50 of 0.17 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
911829 [NCBI]
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2135632-36-7
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Appearance Liquid
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분자량 143.94 kDa
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Color Colorless to light yellow
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SMILES
[Maftivimab]
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Synonyms
REGN3470-3471-3479
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Markham A. REGN-EB3: First Approval. Drugs. 2021 Jan;81(1):175-178.
[2]. Gaudinski MR, et al. Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study. Lancet. 2019 Mar 2;393(10174):889-898. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Maftivimab Related Classifications
HY-P99722 Related Classifications
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