2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PEPCK

PEPCK

Phosphoenolpyruvate Carboxykinase

PEPCK (Phosphoenolpyruvate carboxykinase) is an enzyme in the lyase family used in four pathways: gluconeogenesis, glyceroneogenesis, the synthesis of serine, and the conversion of the carbon skeletons of amino acids. PEPCK is the rate-limiting enzyme of gluconeogenesis in the liver and kidney, and is also a key regulator of TCA cycle flux. PEPCK can catalyze oxaloacetate into phosphoenolpyruvate (PEP) and carbon dioxide. PEPCK has two isoforms: PEPCK1 (PEPCK-C) and PEPCK2 (PEPCK-M). PEPCK1/PEPCK2 is distributed in the cytosol and mitochondria, and is overexpressed in many cancers[1][2].

PEPCK Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-128923
    SKF-34288 hydrochloride
    		Inhibitor
    SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides.
    SKF-34288 hydrochloride
  • HY-111896
    7-Methoxyrosmanol
    		Inhibitor 98.56%
    7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters.
    7-Methoxyrosmanol
  • HY-N3720
    Demethoxycapillarisin
    		Inhibitor ≥98.0%
    Demethoxycapillarisin (6-Demethoxycapillarisin) inhibits PEPCK mRNA levels (IC50: 43 μM) by activation of the PI3K pathway. Demethoxycapillarisin decreases glucose production.
    Demethoxycapillarisin