1. Inflammation/Immunology

Inflammation/Immunology

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Inflammation/Immunology Related Products (1839):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-11109
    Resatorvid 243984-11-4 99.95%
    Resatorvid (TAK-242) is a potent TLR4 signaling inhibitor which selectively inhibits the TLR4-mediated production of cytokines and nitric oxide.
    Resatorvid
  • HY-18739
    Phorbol 12-myristate 13-acetate 16561-29-8 99.66%
    Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator.
    Phorbol 12-myristate 13-acetate
  • HY-10256
    SB 203580 152121-47-6 99.92%
    SB 203580 (RWJ 64809) is a selective and ATP-competitive p38 MAPK inhibitor. SB 203580 (RWJ 64809) inhibits SAPK2a/p38 and SAPK2b/p38β2, with IC50s of 50 nM and 500 nM, respectively. LCK, GSK3β and PKBα are also inhibited by SB 203580 (RWJ 64809), but the IC50s are 100-500-fold higher than that for SAPK2a/p38.
    SB 203580
  • HY-17589
    Chloroquine diphosphate 50-63-5 99.94%
    Chloroquine (diphosphate) is an antimalarial and anti-inflammatory drug widely used to treat malaria and rheumatoid arthritis. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs).
    Chloroquine diphosphate
  • HY-13453
    BAY 11-7082 19542-67-7 99.42%
    BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor which decreases NF-κB by inhibiting TNF-α-induced phosphorylation of IκB-α. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50s of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells[1-5].
    BAY 11-7082
  • HY-B0579
    Cyclosporin A 59865-13-3 >98.0%
    Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM.
    Cyclosporin A
  • HY-14648
    Dexamethasone 50-02-2 99.86%
    Dexamethasone is a glucocorticoid receptor agonist.
    Dexamethasone
  • HY-N0583
    Hydrocortisone 50-23-7 99.90%
    Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone
  • HY-19363
    GW4869 6823-69-4
    GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) with an IC50 of 1 μM.
    GW4869
  • HY-A0098
    Tunicamycin 11089-65-9 99.69%
    Tunicamycin is a N-acetylglucosamine containing antibiotic from Streptomyces lysosuperijkus which inhibits protein glycosylation.
    Tunicamycin
  • HY-100941
    CCCP 555-60-2 99.83%
    CCCP is an oxidative phosphorylation uncoupler.
    CCCP
  • HY-17386
    Rosiglitazone 122320-73-4 99.21%
    Rosiglitazone (BRL 49653) is a selective PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
    Rosiglitazone
  • HY-13756
    Tacrolimus 104987-11-3 99.93%
    Tacrolimus (FK506; Fujimycin) is a macrocyclic lactone with potent immunosuppressive properties. Tacrolimus binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase,immunosuppressant.
    Tacrolimus
  • HY-13205
    Belnacasan 273404-37-8 99.99%
    Belnacasan (VX-765) is a orally active IL-converting enzyme (ICE)/caspase-1 inhibitor, which inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM.
    Belnacasan
  • HY-12885B
    ADU-S100 ammonium salt 1638750-96-5 99.23%
    ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt; MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.
    ADU-S100 ammonium salt
  • HY-12815A
    MCC950 sodium 256373-96-3 99.43%
    MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
    MCC950 sodium
  • HY-15689
    Epacadostat 1204669-58-8 99.65%
    Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM.
    Epacadostat
  • HY-12318
    IBMX 28822-58-4 99.99%
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.
    IBMX
  • HY-16561
    Resveratrol 501-36-0 98.90%
    Resveratrol (SRT 501), a natural polyphenol that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It has a wide spectrum of targets including mTOR, JAK, β-amyloid. Resveratrol also is a specific SIRT1 activator.
    Resveratrol
  • HY-B2176
    ATP 56-65-5 99.18%
    ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells.
    ATP