1. Inflammation/Immunology

Inflammation/Immunology

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Inflammation/Immunology Related Products (1204):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-11109
    TAK-242 243984-11-4 99.95%
    TAK-242 (Resatorvid) is a potent TLR4 signaling inhibitor which selectively inhibits the TLR4-mediated production of cytokines and nitric oxide.
    TAK-242
  • HY-10256
    SB 203580 152121-47-6 99.54%
    SB 203580 is a widely used p38 MAPK inhibitor with an IC50 of 0.3-0.5 μM. It shows more than 100-fold selectivity over PKB, LCK, and GSK-3β.
    SB 203580
  • HY-18739
    Phorbol 12-myristate 13-acetate 16561-29-8 99.08%
    Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a commonly used PKC activator.
    Phorbol 12-myristate 13-acetate
  • HY-17589
    Chloroquine diphosphate 50-63-5 99.94%
    Chloroquine (diphosphate) is an antimalarial and anti-inflammatory drug widely used to treat malaria and rheumatoid arthritis. Chloroquine is an inhibitor of autophagy and toll-like receptors (TLRs).
    Chloroquine diphosphate
  • HY-13453
    BAY 11-7082 19542-67-7 99.42%
    BAY 11-7082 is a NF-κB inhibitor which decreases NF-κB by inhibiting TNF-α-induced phosphorylation of IκB-α. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50s of 0.19 μM and 0.96 μM, respectively.
    BAY 11-7082
  • HY-B0579
    Cyclosporin A 59865-13-3 >98.0%
    Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM.
    Cyclosporin A
  • HY-15689
    INCB 024360 1204669-58-8 99.65%
    INCB 024360 is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM.
    INCB 024360
  • HY-14648
    Dexamethasone 50-02-2 99.70%
    Dexamethasone is a glucocorticoid receptor agonist.
    Dexamethasone
  • HY-N0583
    Hydrocortisone 50-23-7 99.66%
    Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone
  • HY-13756
    Tacrolimus 104987-11-3 98.46%
    Tacrolimus is a macrocyclic lactone with potent immunosuppressive properties. Tacrolimus binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase.
    Tacrolimus
  • HY-17386
    Rosiglitazone 122320-73-4 99.21%
    Rosiglitazone (BRL49653) is a potent thiazolidinedione insulin sensitizer. Rosiglitazone is a selective PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
    Rosiglitazone
  • HY-12885B
    ML RR-S2 CDA ammonium salt 1638750-96-5 99.23%
    ML RR-S2 CDA ammonium salt is an activator of stimulator of interferon genes (STING).
    ML RR-S2 CDA ammonium salt
  • HY-A0098
    Tunicamycin 11089-65-9 99.69%
    Tunicamycin is a N-acetylglucosamine containing antibiotic from Streptomyces lysosuperijkus which inhibits protein glycosylation.
    Tunicamycin
  • HY-16561
    Resveratrol 501-36-0 98.90%
    Resveratrol, a natural polyphenol that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It has a wide spectrum of targets including mTOR, JAK, β-amyloid.
    Resveratrol
  • HY-19363
    GW4869 6823-69-4
    GW4869 is a noncompetitive neutral sphingomyelinase inhibitor with an IC50 of 1 μM.
    GW4869
  • HY-100941
    CCCP 555-60-2 99.83%
    CCCP is an oxidative phosphorylation uncoupler.
    CCCP
  • HY-13205
    VX-765 273404-37-8 99.99%
    VX-765 is an oral prodrug of VRT-043198, a potent and selective caspase-1 inhibitor with a Ki of 0.8 nM.
    VX-765
  • HY-13419
    U-73122 112648-68-7 98.17%
    U-73122 is an inhibitor of phospholipase C (PLC), phospholipase A2, and 5-LO (5-lipoxygenase).
    U-73122
  • HY-15776
    HG-9-91-01 1456858-58-4 98.17%
    HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
    HG-9-91-01
  • HY-12318
    IBMX 28822-58-4 99.99%
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.
    IBMX