1. Inflammation/Immunology

Inflammation/Immunology

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Inflammation/Immunology Related Products (593):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-11109
    TAK-242 243984-11-4 99.95%
    TAK-242 is a novel small molecule TLR4 signaling inhibitor, selectively inhibits the TLR4-mediated production of cytokines and NO.
    TAK-242
  • HY-10256
    SB 203580 152121-47-6 99.54%
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
    SB 203580
  • HY-17589
    Chloroquine diphosphate 50-63-5 99.93%
    Chloroquine (diphosphate) is an antimalarial drug and autophagy/lysosome inhibitor, inhibiting Toll-like receptor (TLR) signalling.
    Chloroquine diphosphate
  • HY-13756
    Tacrolimus 104987-11-3 98.46%
    Tacrolimus binds to FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase (PP2B). Tacrolimus is a mTOR-independent autophagy inducer.
    Tacrolimus
  • HY-14531
    Talarozole 201410-53-9 98.29%
    Talarozole is a potent inhibitor of both CYP26A1 and CYP26B1, with IC50 of 0.46 nM and 5.1 nM for CYP26B1 and CYP26A1, respectively.
    Talarozole
  • HY-15689
    INCB 024360 1204669-58-8 99.65%
    INCB 024360 is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM.
    INCB 024360
  • HY-50912
    Plerixafor octahydrochloride 155148-31-5 98.9%
    Plerixafor octahydrochloride is a CXCR4 antagonist, the IC50 values for GTP-binding and chemotaxis are 27±2.2 and 51±17 nM, respectively.
    Plerixafor octahydrochloride
  • HY-50937
    ST 2825 894787-30-5 99.74%
    ST 2825 is a MyD88 homodimerization inhibitor.
    ST 2825
  • HY-15776
    HG-9-91-01 1456858-58-4
    HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
    HG-9-91-01
  • HY-13740
    Resiquimod 144875-48-9 99.85%
    Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the levels of cytokines such as TNF-α, IL-6 and IFN-α.
    Resiquimod
  • HY-N0583
    Hydrocortisone 50-23-7 99.66%
    Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone
  • HY-15251
    Reparixin 266359-83-5 99.88%
    Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).
    Reparixin
  • HY-13419
    U-73122 112648-68-7 >98.0%
    U-73122 is an inhibitor of phospholipase C (PLC), phospholipase A2, and 5-LO (5-lipoxygenase)
    U-73122
  • HY-10001
    Calcipotriol 112965-21-6 99.5%
    Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
    Calcipotriol
  • HY-B0579
    Cyclosporin A 59865-13-3 >98.0%
    Cyclosporin A is an immunosuppressive agent, that binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, and is widely used in organ transplantation to prevent rejection.
    Cyclosporin A
  • HY-15601
    GS-9620 1228585-88-3 99.56%
    GS-9620 is a potent and selective orally active agonist of Toll-Like Receptor (TLR)7.
    GS-9620
  • HY-14648
    Dexamethasone 50-02-2 98.7%
    Dexamethasone is a glucocorticoid receptor agonist.
    Dexamethasone
  • HY-B0673
    Pirfenidone 53179-13-8 99.84%
    Pirfenidone leads to a reduction of TGF-β2 mRNA levels and of the mature TGF-β2 protein due to decreased expression and direct inhibition of the TGF-β pro-protein convertase furin.
    Pirfenidone
  • HY-13205
    VX-765 273404-37-8 98.94%
    VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor, inhibits IL-1β release with similar potency in PBMCs from FCAS (IC50=0.99±0.29 μM) and control (IC50=1.1±0.61 μM) subjects.
    VX-765
  • HY-50858
    Ruxolitinib phosphate 1092939-17-7 99.89%
    Ruxolitinib (phosphate) is the first potent JAK1/2 inhibitor with IC50 values of 3.3 nM/2.8 nM, more than 130-fold selectivity for JAK1/2 versus JAK3.
    Ruxolitinib phosphate