1. Inflammation/Immunology

Inflammation/Immunology

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Inflammation/Immunology Related Products (2214):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-18739
    Phorbol 12-myristate 13-acetate 16561-29-8 99.66%
    Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator.
    Phorbol 12-myristate 13-acetate
  • HY-11109
    Resatorvid 243984-11-4 99.95%
    Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor and plays pivotal role in various inflammatory diseases. Resatorvid inhibits NO, TNF-R and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF.
    Resatorvid
  • HY-17589
    Chloroquine diphosphate 50-63-5 99.94%
    Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Chloroquine diphosphate is an antimalarial and anti-inflammatory drug widely used to treat malaria and rheumatoid arthritis.
    Chloroquine diphosphate
  • HY-10256
    SB 203580 152121-47-6 99.92%
    SB 203580 (RWJ 64809) is a selective and ATP-competitive p38 MAPK inhibitor. SB 203580 (RWJ 64809) inhibits SAPK2a/p38 and SAPK2b/p38β2, with IC50s of 50 nM and 500 nM, respectively. LCK, GSK3β and PKBα are also inhibited by SB 203580 (RWJ 64809), but the IC50s are 100-500-fold higher than that for SAPK2a/p38.
    SB 203580
  • HY-13453
    BAY 11-7082 19542-67-7 99.42%
    BAY 11-7082 (BAY 11-7821) is an IKK Inhibitor. BAY 11-7082 (BAY 11-7821) decreases NF-κB by inhibiting TNF-α-induced phosphorylation of IκB-α. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50s of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.
    BAY 11-7082
  • HY-14648
    Dexamethasone 50-02-2 99.86%
    Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18L expression on monocytes.
    Dexamethasone
  • HY-B0579
    Cyclosporin A 59865-13-3 99.85%
    Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.
    Cyclosporin A
  • HY-19363
    GW4869 6823-69-4
    GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) with an IC50 of 1 μM.
    GW4869
  • HY-A0098
    Tunicamycin 11089-65-9 99.69%
    Tunicamycin, a nucleoside antibiotic and an N-glycosylation inhibitor, causes unfolded protein response and is widely used as pharmacological inducer of endoplasmic reticulum stress. Tunicamycin causes G1 arrest.
    Tunicamycin
  • HY-100941
    CCCP 555-60-2 99.83%
    CCCP is an oxidative phosphorylation uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
    CCCP
  • HY-N0583
    Hydrocortisone 50-23-7 99.90%
    Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone
  • HY-12815A
    MCC950 sodium 256373-96-3 99.43%
    MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
    MCC950 sodium
  • HY-17386
    Rosiglitazone 122320-73-4 99.21%
    Rosiglitazone (BRL 49653) is a selective PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.
    Rosiglitazone
  • HY-13756
    Tacrolimus 104987-11-3 99.93%
    Tacrolimus (FK506; Fujimycin; FR900506) is a macrocyclic lactone with potent immunosuppressive properties, an immunosuppressant. Tacrolimus binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription.
    Tacrolimus
  • HY-13205
    Belnacasan 273404-37-8 99.99%
    Belnacasan (VX-765) is an orally bioactive prodrug of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM.
    Belnacasan
  • HY-12318
    IBMX 28822-58-4 99.99%
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.
    IBMX
  • HY-A0003
    Lenalidomide 191732-72-6 99.98%
    Lenalidomide (CC-5013) is a derivative of Thalidomide and an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.
    Lenalidomide
  • HY-B2176
    ATP 56-65-5 99.18%
    ATP is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells.
    ATP
  • HY-16561
    Resveratrol 501-36-0 99.70%
    Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor.
    Resveratrol
  • HY-13740
    Resiquimod 144875-48-9 99.95%
    Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.
    Resiquimod