1. Inflammation/Immunology

Inflammation/Immunology

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Inflammation/Immunology Related Products (1096):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-11109
    TAK-242 243984-11-4 99.95%
    TAK-242 is a potent TLR4 signaling inhibitor, selectively inhibits the TLR4-mediated production of cytokines and NO.
    TAK-242
  • HY-10256
    SB 203580 152121-47-6 99.54%
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
    SB 203580
  • HY-17589
    Chloroquine diphosphate 50-63-5 99.94%
    Chloroquine (diphosphate) is an antimalarial drug and autophagy/lysosome inhibitor, inhibiting Toll-like receptor (TLR) signalling.
    Chloroquine diphosphate
  • HY-18739
    Phorbol 12-myristate 13-acetate 16561-29-8 99.08%
    Phorbol 12-myristate 13-acetate (PMA) is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM.
    Phorbol 12-myristate 13-acetate
  • HY-15689
    INCB 024360 1204669-58-8 99.65%
    INCB 024360 is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM.
    INCB 024360
  • HY-13453
    BAY 11-7082 19542-67-7 99.42%
    BAY 11-7082 is a NF-κB inhibitor. BAY 11-7082 results in decreased NF-κB by inhibiting TNF-α-induced phosphorylation of IκB-α. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with an IC50 of 0.19 μM and 0.96 μM, respectively.
    BAY 11-7082
  • HY-B0579
    Cyclosporin A 59865-13-3 >98.0%
    Cyclosporin A is an immunosuppressive agent binding to the cyclophilin and inhibits calcineurin with an IC50 of 7 nM.
    Cyclosporin A
  • HY-N0583
    Hydrocortisone 50-23-7 99.66%
    Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone
  • HY-14648
    Dexamethasone 50-02-2 99.70%
    Dexamethasone is a glucocorticoid receptor agonist.
    Dexamethasone
  • HY-13756
    Tacrolimus 104987-11-3 98.46%
    Tacrolimus binds to FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase (PP2B). Tacrolimus is a mTOR-independent autophagy inducer.
    Tacrolimus
  • HY-17386
    Rosiglitazone 122320-73-4 99.21%
    Rosiglitazone is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
    Rosiglitazone
  • HY-16561
    Resveratrol 501-36-0 98.90%
    Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.
    Resveratrol
  • HY-12885B
    ML RR-S2 CDA ammonium salt 1638750-96-5 99.93%
    ML RR-S2 CDA ammonium salt is an inducer of STING (stimulator of interferon genes). ML RR-S2 CDA has enhanced binding affinity to STING and activate all known human STING alleles.
    ML RR-S2 CDA ammonium salt
  • HY-13205
    VX-765 273404-37-8 99.46%
    VX-765 is an orally active IL-converting enzyme/caspase-1 inhibitor, inhibits IL-1β release with similar potency in PBMCs from FCAS (IC50=0.99±0.29 μM) and control (IC50=1.1±0.61 μM) subjects.
    VX-765
  • HY-15776
    HG-9-91-01 1456858-58-4 98.17%
    HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
    HG-9-91-01
  • HY-13419
    U-73122 112648-68-7 98.17%
    U-73122 is an inhibitor of phospholipase C (PLC), phospholipase A2, and 5-LO (5-lipoxygenase)
    U-73122
  • HY-10046
    Plerixafor 110078-46-1 >98.0%
    Plerixafor is a selective CXCR4 antagonist with IC50 of 44 nM.
    Plerixafor
  • HY-A0098
    Tunicamycin 11089-65-9 98.00%
    Tunicamycin is a mixture of homologous nucleoside antibiotics.
    Tunicamycin
  • HY-50937
    ST 2825 894787-30-5 99.51%
    ST 2825 is a MyD88 homodimerization inhibitor.
    ST 2825
  • HY-12318
    IBMX 28822-58-4 99.93%
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50 of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, PDE4 and PDE5, respectively.
    IBMX