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Cyclosporin A (Synonyms: Cyclosporine; Ciclosporin)

Cat. No.: HY-B0579 Purity: >98.0%
Data Sheet SDS Handling Instructions

Cyclosporin A is an immunosuppressive agent, that binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, and is widely used in organ transplantation to prevent rejection.

For research use only. We do not sell to patients.
Cyclosporin A Chemical Structure

Cyclosporin A Chemical Structure

CAS No. : 59865-13-3

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Description

Cyclosporin A is an immunosuppressive agent, that binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, and is widely used in organ transplantation to prevent rejection.

IC50 & Target

IC50: 7 nM (calcineurin)

In Vitro

Cyclosporin A binds to the cyclophilin (immunophilin) in T cells[1], and forms a Cyclophilin-Cyclosporin A complex which inhibits calcineurin[2]. Cyclosporin A inhibits calcineurin with IC50 of 7 nM[3], then blocks the nuclear translocation of NF-AT[4]. Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM[5]

In Vivo

Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs[6]. Cyclosporin A is clinically used in organ transplantation to prevent rejection[7]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00375895 Rennes University Hospital|Novartis Chronic Hepatitis C|Evidence of Liver Transplantation June 2006 Phase 3
NCT02397213 Region Skane|NeuroVive Pharmaceutical AB Acute Kidney Injury April 2015 Phase 2
NCT00919815 London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Leprosy August 2010 Phase 2|Phase 3
NCT00919451 London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Leprosy August 2010 Phase 2
NCT00919542 London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Leprosy July 2010 Phase 2
NCT02390674 Newcastle-upon-Tyne Hospitals NHS Trust|National Institute for Health Research, United Kingdom|Newcastle University Myocardial Reperfusion Injury March 2015 Phase 2
NCT00919776 London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Leprosy August 2010 Phase 2
NCT00773292 Imperial College London|Medical Research Council|Selly Oak Hospital, Birmingham, UK|St Mary Hospital, Imperial College Healthcare NHS Trust, London, UK HTLV I Associated Myelopathy August 2006 Phase 2|Phase 3
NCT02366585 PerioC Limited Periodontitis March 2015 Phase 2
NCT01751126 Santen SAS Vernal Keratoconjunctivitis March 2013 Phase 3
NCT00232063 Novartis Pharmaceuticals|Novartis Severe Atopic Dermatitis May 2004 Phase 3
NCT00232076 Novartis Pharmaceuticals|Novartis Severe Atopic Dermatitis May 2004 Phase 3
NCT00814515 Santen SAS Moderate to Severe Dry Eye Syndrome September 2007 Phase 3
NCT01968057 Eli Lilly and Company Healthy Volunteers October 2013 Phase 1
NCT00809172 Hospices Civils de Lyon Atopic Dermatitis December 2008 Phase 3
NCT02280421 Maruho Europe Limited Healthy October 2014 Phase 1
NCT01231854 Technische Universität Dresden Atopic Dermatitis November 2010 Phase 4
NCT00182559 Medical University of Vienna End Stage Renal Disease April 2004 Phase 4
NCT00403728 Hospices Civils de Lyon Myocardial Infarction September 2004 Phase 2|Phase 3
NCT01135641 Nantes University Hospital Graft Versus Host Disease June 2010 Phase 2
NCT00408187 Aurinia Pharmaceuticals Inc. Psoriasis December 2006 Phase 3
NCT00578370 ISDIN Psoriasis November 2007 Phase 1|Phase 2
NCT00159159 Hospices Civils de Lyon Cardiac Transplantion March 2004 Phase 4
NCT00445081 Technische Universität Dresden Atopic Dermatitis March 2007 Phase 4
NCT00160966 University of Giessen|Heidelberg University|Hoffmann-La Roche|Astellas Pharma Inc|Novartis Polyomavirus Infections September 2004 Phase 4
NCT00456235 University Hospital, Limoges Liver Transplantation September 2006 Phase 4
NCT00133887 Hospices Civils de Lyon Skin Cancer|Kidney Transplantation April 2004 Phase 3
NCT00148746 Technische Universität Dresden Moderate to Severe Atopic Dermatitis May 2004
NCT00866684 Charite University, Berlin, Germany Kidney Transplantation|Skin Cancer January 2007 Phase 4
NCT00916045 King's College Hospital NHS Trust Leukemia, Myeloid, Acute|Myelodysplastic Syndromes|Leukemia, Lymphoblastic, Acute|Lymphoma, Non-Hodgkin|Hodgkin Disease|Chronic Lymphocytic Leukemia September 2009 Phase 2
NCT00375895 Rennes University Hospital|Novartis Chronic Hepatitis C|Evidence of Liver Transplantation June 2006 Phase 3
NCT02397213 Region Skane|NeuroVive Pharmaceutical AB Acute Kidney Injury April 2015 Phase 2
NCT00919815 London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Leprosy August 2010 Phase 2|Phase 3
NCT00919451 London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Leprosy August 2010 Phase 2
NCT00919542 London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Leprosy July 2010 Phase 2
NCT02390674 Newcastle-upon-Tyne Hospitals NHS Trust|National Institute for Health Research, United Kingdom|Newcastle University Myocardial Reperfusion Injury March 2015 Phase 2
NCT00919776 London School of Hygiene and Tropical Medicine|Homes and Hospitals of St Giles|Alert Hospital, Ethiopia|Armauer Hansen Research Institute, Ethiopia Leprosy August 2010 Phase 2
NCT00773292 Imperial College London|Medical Research Council|Selly Oak Hospital, Birmingham, UK|St Mary Hospital, Imperial College Healthcare NHS Trust, London, UK HTLV I Associated Myelopathy August 2006 Phase 2|Phase 3
NCT02366585 PerioC Limited Periodontitis March 2015 Phase 2
NCT01751126 Santen SAS Vernal Keratoconjunctivitis March 2013 Phase 3
NCT00232063 Novartis Pharmaceuticals|Novartis Severe Atopic Dermatitis May 2004 Phase 3
NCT00232076 Novartis Pharmaceuticals|Novartis Severe Atopic Dermatitis May 2004 Phase 3
NCT00814515 Santen SAS Moderate to Severe Dry Eye Syndrome September 2007 Phase 3
NCT01968057 Eli Lilly and Company Healthy Volunteers October 2013 Phase 1
NCT00809172 Hospices Civils de Lyon Atopic Dermatitis December 2008 Phase 3
NCT02280421 Maruho Europe Limited Healthy October 2014 Phase 1
NCT01231854 Technische Universität Dresden Atopic Dermatitis November 2010 Phase 4
NCT00182559 Medical University of Vienna End Stage Renal Disease April 2004 Phase 4
NCT00403728 Hospices Civils de Lyon Myocardial Infarction September 2004 Phase 2|Phase 3
NCT01135641 Nantes University Hospital Graft Versus Host Disease June 2010 Phase 2
NCT00408187 Aurinia Pharmaceuticals Inc. Psoriasis December 2006 Phase 3
NCT00578370 ISDIN Psoriasis November 2007 Phase 1|Phase 2
NCT00159159 Hospices Civils de Lyon Cardiac Transplantion March 2004 Phase 4
NCT00445081 Technische Universität Dresden Atopic Dermatitis March 2007 Phase 4
NCT00160966 University of Giessen|Heidelberg University|Hoffmann-La Roche|Astellas Pharma Inc|Novartis Polyomavirus Infections September 2004 Phase 4
NCT00456235 University Hospital, Limoges Liver Transplantation September 2006 Phase 4
NCT00133887 Hospices Civils de Lyon Skin Cancer|Kidney Transplantation April 2004 Phase 3
NCT00148746 Technische Universität Dresden Moderate to Severe Atopic Dermatitis May 2004
NCT00866684 Charite University, Berlin, Germany Kidney Transplantation|Skin Cancer January 2007 Phase 4
NCT00916045 King's College Hospital NHS Trust Leukemia, Myeloid, Acute|Myelodysplastic Syndromes|Leukemia, Lymphoblastic, Acute|Lymphoma, Non-Hodgkin|Hodgkin Disease|Chronic Lymphocytic Leukemia September 2009 Phase 2
NCT01642979 Institute of Hematology & Blood Diseases Hospital Paroxysmal Nocturnal Hemoglobinuria|Hemoglobinuria|Hemoglobinuria, Paroxysmal|Proteinuria|Urination Disorders|Thrombosis|Bone Marrow Failure|Aplastic Anemia,|Anemia, Hemolytic July 2012 Phase 2
NCT01760096 Institute of Hematology & Blood Diseases Hospital Paroxysmal Nocturnal Hemoglobinuria|Hemoglobinuria|Hemoglobinuria, Paroxysmal|Proteinuria|Urination Disorders|Thrombosis|Bone Marrow Failure|Aplastic Anemia,|Anemia, Hemolytic January 2013 Phase 2
NCT00359814 Hannover Medical School|Hoffmann-La Roche Heart Transplantation November 2004
NCT02203422 Shandong University Immune Thrombocytopenia July 2014 Phase 3
NCT03026946 University Medical Center Groningen|ZonMw: The Netherlands Organisation for Health Research and Development Hand Eczema May 29, 2017 Phase 3
NCT02706470 Fudan University Miscarriage, Recurrent May 2016 Phase 2|Phase 3
NCT02370550 Peking University People's Hospital Sjogren's Syndrome March 2015 Phase 4
NCT00359658 Hannover Medical School|Hoffmann-La Roche Heart Transplantation November 2004
NCT00565669 Medical University of South Carolina Dry Eye Syndrome October 2007
NCT00905073 Georgetown University Type 1 Diabetes Mellitus February 1990
NCT00167583 University Hospital Tuebingen Behcet's Disease|Panuveitis|Posterior Uveitis|Retinal Vasculitis November 2004 Phase 3
NCT02987257 Ottawa Hospital Research Institute|Canadian Dermatology Foundation|Vanderbilt University Medical Center|Brooke Army Medical Center Stevens-Johnson Syndrome|Toxic Epidermal Necrolyses August 2018 Phase 3
NCT00001731 National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) Keratoconjunctivitis Sicca|Sjogren's Syndrome November 1997 Phase 2
NCT00001737 National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) Eye Disease|Inflammation|Uveitis May 1998 Phase 1
NCT01182662 Shandong University|National Natural Science Foundation of China Aplastic Anemia August 2010 Phase 2
NCT00461825 Poitiers University Hospital Kidney Transplantation July 1998 Phase 3
NCT00001626 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Aplastic Anemia|Hematologic Disease May 2, 1997 Phase 3
NCT00223054 University of Schleswig-Holstein|University of Kiel Function of Renal Transplant March 2005 Phase 4
NCT00332839 Novartis Pharmaceuticals|Novartis Renal Transplantation November 2005 Phase 4
NCT01843348 Novartis Pharmaceuticals|Novartis Kidney Transplantation|Renal Transplantation December 27, 2012 Phase 3
NCT02314312 Mahidol University Transplantation of Kidney|Expanded Criteria Donor|ECD January 2012 Phase 3
NCT00520468 M.D. Anderson Cancer Center Myelodysplastic Syndrome June 2004 Phase 2
NCT00001212 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) Nephrotic Syndrome|Systemic Lupus Erythematosus November 1986 Phase 2
NCT00114777 Bristol-Myers Squibb Renal Transplantation February 2005 Phase 3
NCT00176865 Masonic Cancer Center, University of Minnesota Hemophagocytic Lymphohistiocytosis|X-Linked Lymphoproliferative Disorders|Chediak-Higashi Syndrome|Griscelli Syndrome|Immunologic Deficiency Syndromes|Langerhans-Cell Histiocytosis August 2002 Phase 2
NCT00521924 Merck Sharp & Dohme Corp.|AESCA Pharma GmbH Rheumatoid Arthritis June 2007 Phase 3
NCT01766375 Guangxi Medical University Acute Myeloid Leukemia August 2012 Phase 3
NCT00956293 Novartis Pharmaceuticals|Novartis Renal Transplantation July 2009 Phase 4
NCT02472054 Assistance Publique - Hôpitaux de Paris Hemophagocytic Lymphohistiocytosis (HLH) June 2015 Phase 1|Phase 2
NCT00303667 Masonic Cancer Center, University of Minnesota Acute Myelogenous Leukemia January 2005 Phase 1|Phase 2
NCT00458250 Tehran University of Medical Sciences Leukemia, Myeloid, Acute|Leukemia, Lymphoblastic, Acute September 2006 Phase 1
NCT02487069 Nanfang Hospital of Southern Medical University|Guangdong General Hospital|Third Affiliated Hospital, Sun Yat-Sen University|Guangzhou General Hospital of Guangzhou Military Command|Guangzhou First People's Hospital|Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University|Zhujiang Hospital|Tongji Hospital|Wuhan Union Hospital, China|Fujian Medical University Union Hospital|First Affiliated Hospital of Guangxi Medical University|Xiangya Hospital of Central South University Acute Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome June 2015
NCT01693393 Charite University, Berlin, Germany Sjögren´s Syndrome March 2010 Phase 2
NCT00332462 Novartis Pharmaceuticals|Novartis Liver Transplantation May 2006 Phase 4
NCT01768312 Hanlim Pharm. Co., Ltd. Dry Eye Syndromes March 2012 Phase 3
NCT02144025 Hospital Universitario Dr. Jose E. Gonzalez Graft-Versus-Host Disease May 2014 Phase 2
NCT01494597 Astellas Pharma Inc|Basilea Pharmaceutica International Ltd Healthy November 2011 Phase 1
NCT00438360 Novartis Pharmaceuticals|Novartis Chronic Plaque Psoriasis May 2006 Phase 3
NCT01080586 Panacea Biotec Ltd Healthy Volunteers September 2007
NCT01080560 Panacea Biotec Ltd Healthy Volunteers August 2007
NCT01990898 The Cleveland Clinic Interstitial Cystitis November 2013 Phase 2
NCT00070291 Eastern Cooperative Oncology Group|National Cancer Institute (NCI) Lymphoma September 2005 Phase 2
NCT00050648 Rockefeller University|Facet Biotech Psoriasis October 1997 Phase 1|Phase 2
NCT00860496 Pfizer Healthy Volunteers June 2009 Phase 1
NCT00783107 University of Pittsburgh Chronic Obstructive Pulmonary Disease October 2007 Phase 1
NCT01762657 Perle Bioscience, Inc. Type 1 Diabetes September 2014 Phase 3
NCT00213590 University Hospital, Rouen Kidney Transplantation|Primary Prevention|Kidney Failure April 2000 Phase 3
NCT00990795 The University of Texas Health Science Center, Houston Cardiac Surgical Procedures April 2010 Phase 1
NCT01426334 National Cancer Institute (NCI) Accelerated Phase Chronic Myelogenous Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia|Relapsing Chronic Myelogenous Leukemia September 2011 Phase 1
NCT01990118 Penang Hospital, Malaysia End Stage Renal Failure November 2004 Phase 4
NCT00363779 National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Large Granular Lymphocytic Leukemia|LGL Leukemia June 2006 Phase 2
NCT00739349 Santen SAS Dry Eye August 2008 Phase 2
NCT00260208 Novartis Pharmaceuticals|Novartis Liver Transplant|Hepatitis C January 2006 Phase 4
NCT00154193 Novartis Pharmaceuticals|Novartis Heart and Lung Transplant June 2004 Phase 4
NCT00974142 University of Pittsburgh|National Heart, Lung, and Blood Institute (NHLBI) Chronic Obstructive Pulmonary Disease September 2009 Phase 1|Phase 2
NCT02114073 Mashhad University of Medical Sciences Glaucoma, Open Angle April 2014 Phase 2
NCT01497483 University of California, San Francisco|National Institute of General Medical Sciences (NIGMS) Healthy December 2011 Phase 1
NCT00264355 University of Oslo School of Pharmacy Heart Transplantation|Acute Renal Failure December 2005 Phase 4
NCT00335114 University of Alabama at Birmingham Contact Lens Wearers With Dry Eye Syndrome November 2005
NCT01276457 Novartis Pharmaceuticals|Novartis Transplantation Infection May 2006 Phase 3
NCT00005937 Neal Young, M.D.|National Institutes of Health Clinical Center (CC) Myelodysplastic Syndrome June 2000 Phase 2
NCT00542152 Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives Ulcerative Colitis|Steroid Refractory June 2007 Phase 4
NCT00938236 APT Pharmaceuticals, Inc. Lung Transplant December 2009 Phase 3
NCT01650662 Mario Negri Institute for Pharmacological Research|Heart Care Foundation Acute Myocardial Infarction January 2012 Phase 3
NCT01149759 Rockefeller University Atopic Dermatitis|Eczema June 2010
NCT01595958 Hospices Civils de Lyon Non Shockable Out of Hospital Cardiac Arrest June 2010 Phase 3
NCT00821587 University of Florida|Novartis Pharmaceuticals Hepatitis C June 2004 Phase 4
NCT00426023 Campus Bio-Medico University|University of Genova|University of Padova Vernal Keratoconjunctivitis February 2007 Phase 3
NCT00031980 Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Anemia|Leukemia|Neutropenia|Thrombocytopenia March 2002 Phase 2
NCT00983931 Mutual Pharmaceutical Company, Inc. Pharmacokinetics|Healthy August 2008 Phase 1
NCT00003950 University of Chicago|National Cancer Institute (NCI) Colorectal Cancer January 2000 Phase 2
NCT00755781 APT Pharmaceuticals, Inc. Lung Transplant September 2008 Phase 3
NCT02206789 Aravind Eye Care System Corneal Graft Rejection February 2012
NCT00976300 Institute of Rheumatology, Prague|Ministry of Health, Czech Republic|Charles University, Czech Republic|Palacky University|Department of Rheumatology, Hospital, Ceske Budejovice, Czech Republic|National Institute of Rheumatology, Piestany, Slovakia|St. Anna Hospital, Brno, Czech Systemic Lupus Erythematosus|Lupus Nephritis January 2002 Phase 2
NCT00553735 Massachusetts Eye and Ear Infirmary Dry Eye August 2007 Phase 4
NCT02188264 National Cancer Institute (NCI) Recurrent Colorectal Carcinoma|Solid Neoplasm|Stage IIIA Colorectal Cancer AJCC v7|Stage IIIB Colorectal Cancer AJCC v7|Stage IIIC Colorectal Cancer AJCC v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVB Colorectal Cancer AJCC v7 August 5, 2014 Phase 1
NCT00171509 Novartis Liver Transplant May 2004 Phase 4
NCT00818194 Astellas Pharma Inc|Astellas Pharma Canada, Inc. Healthy April 2008 Phase 1
NCT00653276 Merck Sharp & Dohme Corp.|Schering-Plough Cholesterol November 2003 Phase 1
NCT02554981 Allergan Dry Eye Syndromes July 21, 2015 Phase 4
NCT02998645 Novartis Pharmaceuticals|Novartis Severe Aplastic Anemia May 19, 2017 Phase 2
NCT02887807 Hospices Civils de Lyon Shockable Out of Hospital Cardiac Arrest January 2017 Phase 3
NCT01514968 Hoffmann-La Roche Healthy Volunteer December 2011 Phase 1
NCT01718652 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Healthy February 2011 Phase 1
NCT01901471 Hospices Civils de Lyon Acute Myocardial Infarction September 2015 Phase 2
NCT01211327 University Hospital, Ghent|Funds for Research in Ophthalmology (FRO) of Belgium|Novartis Vernal Keratoconjunctivitis July 2008 Phase 4
NCT00755040 Vanderbilt-Ingram Cancer Center|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms October 2008 Phase 3
NCT01429844 Universitätsklinikum Hamburg-Eppendorf Bronchiolitis Obliterans|Immunosuppression January 2001 Phase 3
NCT00991458 Allergan Laser In Situ Keratomileusis October 2009 Phase 2
NCT00824811 M.D. Anderson Cancer Center|Allergan Epiphora June 2009 Phase 2
NCT00903188 University Hospital, Antwerp|Novartis Pharmaceuticals|Erasme University Hospital|University Hospital, Ghent|University Hospital of Liege|Universitair Ziekenhuis Brussel Renal Transplantation October 2008 Phase 4
NCT01231841 The Cleveland Clinic Aplastic Anemia March 2005 Phase 2
NCT01479881 Tibotec Pharmaceuticals, Ireland Hepatitis C Virus October 2011 Phase 1
NCT01650545 University of Maryland Disorder Related to Lung Transplantation|Bronchiolitis Obliterans|Decreased Immunologic Activity|Chronic Rejection of Lung Transplant June 2012 Phase 1|Phase 2
NCT00488436 PETHEMA Foundation Myelodysplastic Syndrome May 2002 Phase 4
NCT00840827 Weill Medical College of Cornell University|Celgene Corporation Myelodysplastic Syndrome December 2008 Phase 2
NCT00611403 Allergan Dry Eye Syndromes December 2007 Phase 2
NCT00171496 Novartis Kidney Transplant October 2003 Phase 4
NCT02229955 Hanlim Pharm. Co., Ltd. Dry Eye Syndromes December 2013 Phase 3
NCT00319878 Office of Rare Diseases (ORD)|Rare Diseases Clinical Research Network Anemia, Aplastic May 2006 Phase 1|Phase 2
NCT02876250 Hospices Civils de Lyon Lung Transplantation January 2017 Phase 3
NCT02655705 Seoul National University Hospital Psoriasis August 2014 Phase 4
NCT02281370 GlaxoSmithKline Purpura, Thrombocytopenic, Idiopathic November 2014 Phase 1
NCT03083782 Thomas Jefferson University|Bristol-Myers Squibb Venous Thromboembolism|Pharmacokinetics|Healthy April 5, 2017 Phase 1
NCT00797030 Universidade Federal do Rio de Janeiro Dry Eye Syndromes|HIV Seropositivity October 2006 Phase 4
NCT00425308 Novartis Pharmaceuticals|Novartis Renal Transplantation October 2006 Phase 3
NCT01193283 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Aplastic Anemia|Neutropenia|Pancytopenia|Severe Aplastic Anemia August 2010 Phase 1|Phase 2
NCT00658320 Novartis Kidney Transplantation February 2008 Phase 3
NCT01648270 Washington University School of Medicine Healthy April 2012
NCT01287078 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Bronchiolitis Obliterans|Graft vs Host Disease January 11, 2011 Phase 2
NCT01319773 Allergan Dry Eye Syndromes November 2010 Phase 1
NCT00827255 Allergan Dry Eye Disease January 2009
NCT02462252 BioLineRx, Ltd. Aplastic Anemia|Hypoplastic Myelodysplastic Syndrome October 2015 Phase 2
NCT00766909 University of Aarhus Complications of Transplanted Organs and Tissue|Diabetes Mellitus Nos New Onset March 2008 Phase 4
NCT02630563 Hoffmann-La Roche Pediatric Liver Transplantation May 2003 Phase 2
NCT01346397 Russian Academy of Medical Sciences|Russian Scientific Center of Surgery Acute Graft Rejection|Chronic Allograft Nephropathy|Polyomavirus-related Transplant Nephropathy April 2009
NCT00806598 M.D. Anderson Cancer Center|Genzyme, a Sanofi Company Myelodysplastic Syndrome|Aplastic Anemia May 2005 Phase 2
NCT02226068 University of Aarhus Atopic Dermatitis June 2002
NCT00171717 Novartis Maintenance Liver Transplant Patients With New Onset Diabetes February 2004 Phase 4
NCT00154284 Novartis Organ Transplantation, Renal Transplantation July 2005 Phase 3
NCT01504906 AstraZeneca Healthy January 2012 Phase 1
NCT00377325 University of Rochester|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Psoriasis June 2007 Phase 2
NCT02121847 Allergan Dry Eye Syndromes April 2014 Phase 4
NCT02701517 Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea Unrecognized Condition: Mature B or T-cell Neoplasm September 2003 Phase 2
NCT00378677 University Medical Center Groningen Lung Transplantation|Bronchiolitis Obliterans February 2007 Early Phase 1
NCT00775632 University Health Network, Toronto|Bayer Graft Versus Host Disease|Bone Marrow Transplantation October 2008 Phase 2
NCT02225756 Assistance Publique - Hôpitaux de Paris Abdominal Aortic Aneurysm,|Small Abdominal Aortic Aneurysm December 2013 Phase 2
NCT01064830 University of North Carolina, Chapel Hill|Allergan Brittle Nail Syndrome February 2010 Phase 2
NCT00149890 Novartis Liver Transplantation|Infection March 2004 Phase 3
NCT00150085 Novartis Tacrolimus-associated Abnormal Glucose Metabolism in Kidney and Liver Transplant Recipients February 2004 Phase 4
NCT00349440 Innovative Medical Dry Eye Syndromes September 2006 Phase 4
NCT01342887 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adul April 2011 Phase 1|Phase 2
NCT02907554 University Hospital, Clermont-Ferrand|University Hospital, Estaing|Centre Hospitalier Universitaire de Nice|Groupe Hospitalier Pitie-Salpetriere|Centre Hospitalier Universitaire de Nīmes|University Hospital, Montpellier|Hôtel Dieu (Nantes)|Poitiers University Hospital|University Hospital, Toulouse|Hôpital de la Timone Brain Death|Kidney Transplantation September 2016 Phase 4
NCT01370343 Pfizer Healthy|Drug Interaction July 2011 Phase 1
NCT00637143 Astellas Pharma Inc|Astellas Pharma Canada, Inc. Renal Transplantation|Chronic Renal Allograft Failure April 1999 Phase 4
NCT02496975 Edward Hall,PhD|University of Kentucky Traumatic Brain Injury July 2015 Phase 1|Phase 2
NCT00404482 St. Franziskus Hospital Uveitis|Juvenile Idiopathic Arthritis January 1991
NCT01299922 Hospital Universitario Fundación Alcorcón|Hospital Universitario 12 de Octubre|Hospital General Universitario Gregorio Marañon|Hospital Universitario Ramon y Cajal|Hospital Infanta Sofia|Hospital Universitario Infanta Leonor|Hospital Universitario Reina Sofia|Hospital Regional Universitario Carlos Haya|Hospital Universitario Virgen de la Victoria|University Hospital of the Nuestra Señora de Candelaria|Hospital Universitario de Guadalajara. Spain|Hospital San Pedro Alcantara. Caceres. Spain|Hospital Juan Canalejo Lupus Nephritis February 2011 Phase 3
NCT00884585 Allergan Atopic Conjunctivitis May 2009 Phase 3
NCT00507793 Wyeth is now a wholly owned subsidiary of Pfizer Kidney Transplantation April 2000 Phase 4
NCT01180036 Mayo Clinic Idiopathic Membranous Nephropathy November 2011 Phase 2|Phase 3
NCT01023815 Novartis de Novo Kidney Transplant Recipients|Renal Transplantation April 2009 Phase 3
NCT02108301 Prof. Dr. Alice Schmidt|Medical University of Vienna Chronic Hepatitis C-virus Infection|Renal Transplantation December 2011 Phase 4
NCT00166816 National Taiwan University Hospital Transplantation|Kidney Transplantation|Immunosuppression March 2002 Phase 4
NCT00154310 Novartis Renal Transplantation June 2005 Phase 4
NCT01788501 Seoul National University Hospital Graft vs Host Disease November 2011 Phase 2|Phase 3
NCT00348335 Ophthalmic Consultants of Long Island|Allergan Rosacea June 2006 Phase 4
NCT01170351 Tehran University of Medical Sciences Autoimmune Hepatitis December 2005 Phase 3
NCT01758107 Chulalongkorn University Renal Transplant August 2010 Phase 4
NCT00713193 Ohio State University Thrombotic Thrombocytopenic Purpura November 2007 Phase 3
NCT00143806 University of Medicine and Dentistry of New Jersey|Biogen|Rutgers, The State University of New Jersey Psoriasis October 2003 Phase 2
NCT00777933 Samsung Medical Center Kidney Transplantation|Living Donors July 2000
NCT00001965 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Cardiomyopathy, Hypertrophic|Heart Hypertrophy December 1999 Phase 2
NCT00000880 National Institute of Allergy and Infectious Diseases (NIAID) HIV Infections Phase 2
NCT00986427 Julian M. Mackay-Wiggan|Allergan|Columbia University Brittle Nails July 2009 Phase 2
NCT00139035 University of Oslo School of Pharmacy Chronic Renal Failure April 2005 Phase 4
NCT00948727 Assistance Publique - Hôpitaux de Paris|Agence de La Biomédecine Hematopoietic Stem Cell Transplantation|Graft Versus Host Disease January 2004 Phase 2
NCT03209219 Peking Union Medical College Hospital Behçet Disease|Uveitis June 30, 2017 Phase 3
NCT00257387 Wyeth is now a wholly owned subsidiary of Pfizer Kidney Transplant June 2004 Phase 1|Phase 2
NCT00195468 Wyeth is now a wholly owned subsidiary of Pfizer Kidney Failure|Graft vs Host Disease March 2004 Phase 4
NCT00993343 Karolinska Institutet Graft-versus-host Disease|Survival September 2007 Phase 3
NCT02686619 Hoffmann-La Roche Renal Transplantation November 2004 Phase 3
NCT00286624 University of Minnesota - Clinical and Translational Science Institute|Juvenile Diabetes Research Foundation|National Institutes of Health (NIH)|Novartis Type 1 Diabetes Mellitus|Hypoglycemia March 2003 Phase 1|Phase 2
NCT00633373 APT Pharmaceuticals, Inc. Lung Transplant
NCT01160276 Assistance Publique - Hôpitaux de Paris|Institut National de la Santé Et de la Recherche Médicale, France Renal Replacement Therapies May 2010 Phase 1
NCT00717418 Allergan Keratoconjunctivitis Sicca September 2004
NCT00008450 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) Adenosine Deaminase Deficiency|Autosomal Recessive Disorder|Immune System Disorder|Purine-Nucleoside Phosphorylase Deficiency|Severe Combined Immunodeficiency|Severe Combined Immunodeficiency With Absence of T and B Cells|X-Linked Severe Combined Immunodeficiency August 11, 1997 Phase 1
NCT00228020 Novartis Pediatric Kidney Transplantation May 2001 Phase 3
NCT00001533 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Anemia|Leukemia, T-Cell|Lymphocytosis|Neutropenia|Thrombocytopenia September 1996 Phase 1
NCT00149994 Novartis Pharmaceuticals|Novartis Liver Transplant December 2002 Phase 4
NCT01273207 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Bronchiolitis Obliterans|Constructive Bronchiolitis|Graft Versus Host Disease December 22, 2010 Phase 2
NCT00171743 Novartis Liver Transplant April 2004 Phase 4
NCT01109056 Allergan Pterygium June 2010 Phase 2
NCT00102583 National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) Graft Vs Host Disease October 14, 2004 Phase 1
NCT00298324 European Group for Blood and Marrow Transplantation|Novartis Graft vs Host Disease September 2006 Phase 3
NCT01598987 Novartis Pharmaceuticals|Novartis Renal Function|Liver Transplant October 2012 Phase 3
NCT01038167 Vertex Pharmaceuticals Incorporated|Tibotec Pharmaceutical Limited Hepatitis C January 2010 Phase 1
NCT02176733 University Hospital, Angers Leber Hereditary Optic Neuropathy July 2011 Phase 2
NCT00110110 The Hospital for Sick Children|Terry Fox Foundation Retinoblastoma June 2004 Phase 2
NCT01268995 Medical University of Vienna New Onset Diabetes Mellitus After Renal Transplantation September 2009 Phase 2
NCT00389870 University of Leeds|National Cancer Institute (NCI) Colorectal Cancer December 2006 Phase 3
NCT00089050 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia May 2004 Phase 2
NCT00977977 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) Nephrotic Syndrome|Proteinuria|Autoimmune Disease|Glomerular Disease|Membranous Glomerulonephritis August 28, 2009 Phase 2
NCT00895739 Federico II University|National Cancer Institute (NCI) Nonmalignant Neoplasm June 2006 Phase 2
NCT00371826 Novartis Pharmaceuticals|Novartis Renal Transplanted Recipients March 2006 Phase 4
NCT00001839 National Institutes of Health Clinical Center (CC) Hematologic Diseases|Myelodysplastic Syndromes December 1998 Phase 2
NCT00005935 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Aplastic Anemia June 2000 Phase 2
NCT02016625 Boehringer Ingelheim Healthy December 2013 Phase 1
NCT00428064 Wyeth is now a wholly owned subsidiary of Pfizer Renal Transplantation May 1998 Phase 3
NCT02013791 Allergan Dry Eye Syndromes April 2014 Phase 2
NCT00328653 Santen SAS Conjunctivitis, Vernal May 2006 Phase 2|Phase 3
NCT01762644 Perle Bioscience, Inc.|Syreon Corporation Type 1 Diabetes August 2015 Phase 3
NCT00002759 National Cancer Institute (NCI) Drug/Agent Toxicity by Tissue/Organ|Lymphoma|Neutropenia|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific June 1996 Phase 1
NCT00928018 Dana-Farber Cancer Institute|Brigham and Women's Hospital|Massachusetts General Hospital|National Cancer Institute (NCI) Non-hodgkin Lymphoma|Hodgkin Lymphoma June 2009 Phase 3
NCT00349583 Innovative Medical Cataract|Dry Eye Phase 4
NCT00209859 Hvidovre University Hospital Rheumatoid Arthritis October 1998 Phase 4
NCT00525681 University of Oslo School of Pharmacy Renal Transplantation September 2007 Phase 4
NCT00002688 University Medical Center Groningen|National Cancer Institute (NCI) Leukemia February 1995 Phase 2
NCT00112593 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Accelerated Phase Chronic Myelogenous Leukemia|Acute Undifferentiated Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Grade III Lymphom November 1999
NCT00541814 University Hospital Birmingham|Novartis Chronic Allograft Nephropathy October 2007 Phase 4
NCT00064701 Astellas Pharma Inc Kidney Transplantation June 2003 Phase 3
NCT00006251 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Undifferentiated Leukemia|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Grade III Lymphomatoid Granulomatosis|Childhood Immunoblastic Large Cell Lymphoma|Childhood Myelodysplastic Syndromes|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Chronic Myelomonocytic Leukemia|Cutaneous B-cell Non-Hodgkin Lymphoma|de Novo Myelodysplastic Syndromes|Extrano May 2000 Phase 1|Phase 2
NCT02865356 Spherium Biomed|Germans Trias i Pujol Hospital|Hospital del Mar|Hospital Sant Joan de Deu|Hospital Universitario Virgen Macarena|Hospital Universitario La Fe|Hospital General Universitario de Alicante|Fundación de Investigación Biomédica - Hospital Universitario de La Princesa|Hospital Universitario Virgen de la Victoria|Hospital Infantil Universitario Niño Jesús, Madrid, Spain Atopic Dermatitis September 2016 Phase 2
NCT00007787 National Institute of Allergy and Infectious Diseases (NIAID) Kidney Transplantation|Chronic Allograft Nephropathy April 2000
NCT01251575 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Adult Acute Lymphoblastic Leukemia|Adult Acute Myeloid Leukemia|Adult Diffuse Large B-Cell Lymphoma|Adult Myelodysplastic Syndrome|Adult Non-Hodgkin Lymphoma|Aggressive Non-Hodgkin Lymphoma|Childhood Acute Lymphoblastic Leukemia|Childhood Acute Myeloid Leukemia|Childhood Diffuse Large B -Cell Lymphoma|Childhood Myelodysplastic Syndrome|Childhood Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia in Remission|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positiv December 2010 Phase 2
NCT00987207 Hospices Civils de Lyon Aortic Valvular Surgery October 2008 Phase 3
NCT01624805 M.D. Anderson Cancer Center Leukemia June 2012 Phase 2
NCT00634920 Novartis Pharmaceuticals|Novartis Renal Function March 2008 Phase 4
NCT03013933 City of Hope Medical Center|National Cancer Institute (NCI) Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma|CD30-Positive Neoplastic Cells Present March 8, 2017 Phase 1
NCT00078858 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Grade III Lymphomatoid Granulomatosis|Adult Nasal September 2003 Phase 1|Phase 2
NCT00548301 Sirion Therapeutics, Inc. Dry Eye Syndromes Phase 3
NCT00502073 Sirion Therapeutics, Inc. Dry Eye Syndromes Phase 3
NCT00031070 National Institute of Allergy and Infectious Diseases (NIAID) HIV Infections Phase 2
NCT02936505 Vastra Gotaland Region Lung Transplantation|Allografts October 2016
NCT00549289 Sirion Therapeutics, Inc. Dry Eye Syndromes Phase 3
NCT00035555 Bristol-Myers Squibb Graft Rejection|Kidney Transplantation|Renal Transplantation March 2001 Phase 2
NCT00066794 Southwest Oncology Group|National Cancer Institute (NCI) Leukemia July 2004 Phase 2
NCT00383396 Innovative Medical Pterygia Phase 4
NCT00003056 Baxalta US Inc. Graft Versus Host Disease|Leukemia|Lymphoma April 1997 Phase 3
NCT00295425 University Hospital Muenster|Hoffmann-La Roche Psoriasis May 2000 Phase 2
NCT00420537 University of Bologna Kidney Dysfunction|Heart Transplantation September 2006 Phase 4
NCT00820911 Novartis Pharmaceuticals|Novartis Kidney Transplantation September 2008 Phase 2
NCT00048165 Hoffmann-La Roche Heart Transplantation August 1999 Phase 4
NCT00001964 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Severe Aplastic Anemia December 1, 1999 Phase 2
NCT00003920 University of California, Davis|National Cancer Institute (NCI) Breast Cancer April 1996 Phase 1
NCT00009776 University of California, Davis|National Cancer Institute (NCI) Lymphoma March 2001 Phase 1
NCT01288131 Chulalongkorn University Anti-r-HuEpo Associated PRCA Subjects January 2009 Phase 3
NCT00300274 Novartis Pharmaceuticals|Novartis Graft Rejection January 2006 Phase 3
NCT03150134 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Acute Myeloid Leukemia|Disorder Related to Bone Marrow Transplantation January 1, 2010 Phase 4
NCT00009763 University of California, Davis|National Cancer Institute (NCI) Breast Cancer March 2001 Phase 1
NCT00729768 Genentech, Inc. Kidney Transplantation Phase 2|Phase 3
NCT00905515 East Carolina University|Astellas Pharma US, Inc. Kidney Transplantation August 2003 Phase 4
NCT00093587 Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) Graft Versus Host Disease|Leukemia August 2004
NCT00812123 University Hospital, Basel, Switzerland|Wyeth is now a wholly owned subsidiary of Pfizer Kidney Transplantation|Chronic Kidney Disease January 2001 Phase 4
NCT01334892 Pari Pharma GmbH Bronchiolitis Obliterans December 2009 Phase 2|Phase 3
NCT00251004 Novartis Kidney Transplantation|Graft Rejection October 2005 Phase 3
NCT00027443 Mayo Clinic|FDA Office of Orphan Products Development Myocarditis August 2001
NCT00139009 University of Oslo School of Pharmacy Renal Transplantation|Heart Transplantation June 2005 Phase 4
NCT00167947 Wyeth is now a wholly owned subsidiary of Pfizer Kidney Failure|Graft vs Host Disease January 2005 Phase 3
NCT00157014 Astellas Pharma Inc|Astellas Pharma Canada, Inc. Heart Diseases|Heart Transplantation May 10, 2004 Phase 3
NCT00001749 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Fanconi's Anemia|Hematologic Disease July 1998 Phase 2
NCT00493194 University Hospital, Antwerp|Wyeth is now a wholly owned subsidiary of Pfizer|Hoffmann-La Roche Kidney Failure, Chronic|Transplantation|Immunosuppression|Interstitial Fibrosis May 2005 Phase 4
NCT02617667 Novaliq GmbH Dry Eye Syndromes January 2016 Phase 2
NCT02276001 Kowa Research Institute, Inc. Healthy June 2014 Phase 1
NCT02091414 Hoffmann-La Roche Heart Transplantation August 2006 Phase 3
NCT02688556 Ocular Technologies SARL Keratoconjunctivitis Sicca February 2016 Phase 3
NCT00016419 Southwest Oncology Group|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes August 2001 Phase 2
NCT00812786 University Hospital, Limoges Heart Transplant July 2007 Phase 4
NCT01818726 Novartis Pharmaceuticals|Novartis Aplastic Anemia June 23, 2014 Phase 4
NCT00002456 Fred Hutchinson Cancer Research Center Graft Versus Host Disease|Leukemia|Lymphoma May 1986 Phase 3
NCT00343785 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI) Aplastic Anemia February 2006 Phase 2
NCT00119366 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Childhood Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukem May 2003 Phase 2
NCT02203396 Yizhou Zheng|Institute of Hematology & Blood Diseases Hospital Aplastic Anemia August 2014 Phase 2
NCT00402168 Bristol-Myers Squibb Renal Transplant January 2007 Phase 2
NCT00087581 Hoffmann-La Roche Kidney Transplantation June 2004 Phase 4
NCT00255684 University of Rochester Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms December 2003
NCT01380535 Mallinckrodt|Parexel Chronic Graft Versus Host Disease November 2011 Phase 1
NCT00118352 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Undifferentiated Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood March 2005 Phase 2
NCT00268515 National Heart, Lung, and Blood Institute (NHLBI) Lung Diseases April 1998 Phase 2
NCT00195273 Wyeth is now a wholly owned subsidiary of Pfizer Graft vs Host Disease|Kidney Transplantation November 2004 Phase 3
NCT00002790 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes March 1996 Phase 1|Phase 2
NCT00010361 Fred Hutchinson Cancer Research Center|Office of Rare Diseases (ORD) Metabolism, Inborn Errors|Granulomatous Disease, Chronic November 2000
NCT02660684 Astellas Pharma Korea, Inc.|Astellas Pharma Inc Graft Versus Host Disease February 2008 Phase 4
NCT00085449 Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms May 2006 Phase 1|Phase 2
NCT00070187 Children's Oncology Group|National Cancer Institute (NCI) Lymphoma November 2003 Phase 2|Phase 3
NCT00518375 Wyeth is now a wholly owned subsidiary of Pfizer Kidney Transplantation April 2000 Phase 4
NCT02005562 Hoffmann-La Roche Kidney Transplantation May 2006 Phase 3
NCT02478424 Rabin Medical Center Graft vs Host Disease July 2015 Phase 2
NCT01699360 Central South University Kidney Transplantation September 2012 Phase 4
NCT00427661 University of Pittsburgh|Children's Hospital of Pittsburgh Sickle Cell Disease|Thalassemia|Hemoglobinopathies June 2002
NCT00425724 Oulu University Hospital Purpura, Schoenlein-Henoch January 2000 Phase 4
NCT00008177 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia| July 1999 Phase 1
NCT02144857 University of Athens Psoriasis January 2013 Phase 4
NCT00003145 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Accelerated Phase of Disease|Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase of Disease|Recurrent Disease August 1997 Phase 2
NCT00004482 Mayo Clinic Myocarditis|Giant Cell Myocarditis December 1999 Phase 2
NCT01938625 Janssen R&D Ireland Hepatitis C, Chronic December 2013 Phase 2
NCT01552629 Novartis Pharmaceuticals|Novartis Atopic Dermatitis January 5, 2012 Phase 2
NCT00119340 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia April 2005 Phase 1|Phase 2
NCT01028092 University Hospital, Brest|Novartis|Roche Pharma AG|Genzyme, a Sanofi Company|Ministry of Health, France Renal Transplant March 2009 Phase 3
NCT00972660 Guangdong General Hospital|Sun Yat-sen University Graft Versus Host Disease September 2009 Phase 2
NCT00003625 Children's Oncology Group|National Cancer Institute (NCI) Brain Tumors|Central Nervous System Tumors December 1998 Phase 1
NCT01995331 Xiaofan Zhu|Chinese Academy of Medical Sciences Aplastic Anemia March 2012 Phase 4
NCT00453388 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) Acute Myeloid Leukemia in Remission|de Novo Myelodysplastic Syndrome|Fanconi Anemia|Previously Treated Myelodysplastic Syndrome February 2007 Phase 2
NCT00123331 Heidelberg University|Wyeth is now a wholly owned subsidiary of Pfizer Heart Transplantation|Renal Failure October 2003 Phase 4
NCT00419926 Novartis Kidney Transplantation December 2006 Phase 4
NCT00290641 Masonic Cancer Center, University of Minnesota|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Myelodysplastic Syndromes April 2001
NCT01804361 DH Bio Co., Ltd.|BTO Pharm. Co., Ltd. Dry Eye Syndromes March 2013 Phase 3
NCT00369382 Wyeth is now a wholly owned subsidiary of Pfizer Graft Rejection|Kidney Failure September 2006 Phase 4
NCT00896493 Stanford University Mycoses|Sezary Syndrome|Lymphoma, T-Cell, Cutaneous|Bone Marrow Transplant Failure|Lymphoma, Non-Hodgkin|Cutaneous T-cell Lymphoma May 2009 Phase 2
NCT00752479 Mario Negri Institute for Pharmacological Research Kidney Transplant May 2008 Phase 1|Phase 2
NCT02799888 Affiliated Hospital to Academy of Military Medical Sciences Graft-versus-host Disease|Hematopoietic Stem Cell Transplantation April 2014 Phase 2
NCT00663455 University of Erlangen-Nürnberg Medical School Kidney Transplant December 2008 Phase 4
NCT00166842 National Taiwan University Hospital Transplantation|Kidney Transplantation|Immunosuppression September 2002 Phase 4
NCT01469884 Irmandade Santa Casa de Misericórdia de Porto Alegre|Novartis Renal Allograft|Hepatitis C November 2011 Phase 4
NCT00003196 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Re September 1997
NCT00556257 Pfizer Kidney Transplantation August 2007 Phase 2
NCT00008021 University of California, Davis|National Cancer Institute (NCI) Lymphoma February 2001 Phase 1
NCT00452361 Wyeth is now a wholly owned subsidiary of Pfizer Kidney Transplantation April 2007 Phase 4
NCT00005941 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Cervical Cancer|Vaginal Cancer November 1999 Phase 2
NCT00944749 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Anemia, Aplastic|Anemia, Hypoplastic July 2009 Phase 2
NCT01820572 Bristol-Myers Squibb Kidney Transplantation March 27, 2013 Phase 3
NCT01289301 Hannover Medical School Disorder Related to Renal Transplantation|Immunosuppression Related Infectious Disease|Virus Diseases October 2011 Phase 4
NCT00000936 National Institute of Allergy and Infectious Diseases (NIAID) Kidney Transplantation November 1999 Phase 3
NCT00163657 Baylor Research Institute|Baylor Health Care System|Emory University|University of Southern California|Mayo Clinic - Scottsdale/Phoenix, Arizona|New York Presbyterian Hospital|Oregon Health and Science University|New York University|University of Cincinnati|University of Alabama at Birmingham|The University of Texas Health Science Center at San Antonio|University of Chicago|University of California, San Francisco|Mayo Clinic - Rochester, Minnesota|Medical University of South Carolina|University of Virginia|Lahey Clinic|University of Medicine and Dentistry of New Jersey|Northwestern Memorial Hospital End Stage Liver Disease|Hepatitis C July 2002 Phase 4
NCT00096161 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Chronic Lymphocytic Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Graft Versus Host Disease|Hodgkin Lymphoma|Myelodysplastic/Myeloproliferative Neoplasm|Non-Hodgkin Lymphoma|Plasma Cell Myeloma|Waldenstrom Macroglobulinemia May 2003 Phase 2
NCT03136237 BioCryst Pharmaceuticals Hereditary Angioedema February 17, 2017 Phase 1
NCT01129739 Shandong University|National Natural Science Foundation of China Myelodysplastic Syndromes May 2010 Phase 2
NCT01410448 Novartis Pharmaceuticals|Novartis Kidney Transplantation November 2011 Phase 3
NCT00741338 Genzyme, a Sanofi Company|BioMarin/Genzyme LLC|Sanofi Mucopolysaccharidosis I September 2008 Phase 1|Phase 2
NCT00118742 Hoffmann-La Roche Liver Transplantation August 2005 Phase 4
NCT02342145 Affiliated hospital of guangxi medical university,china|Union hospital of Fujian Medical University|Zhongshan Hospital Xiamen University|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School|Kunming general Hospital of Chengdu Military Region|First Affiliated Hospital of Guangxi Medical University Beta-Thalassemia Major June 2014 Phase 4
NCT02181478 Case Comprehensive Cancer Center|National Cancer Institute (NCI) Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Myelodysplastic Syndromes|Myelofibrosis|Relapsed Non-Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma|Hodgkin Lymphoma|Refractory Hodgkin Lymphoma|Relapsed Chronic Lymphocytic Leukemia|Refractory Chronic Lymphocytic Leukemia|Lymphoid Malignancies|Chronic Myelogenous Leukemia July 2015
NCT00075478 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia in Remission|Aggressive Non-Hodgkin Lymphoma|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Diffuse Large B-Cell Lymphoma|Hematopoietic and Lymphoid Cell Neoplasm|Indolent Non-Hodgkin Lymphoma|Mantle Cell Lymphoma|Myelodysplastic/Myeloproliferative Neoplasm|Plasma Cell Myeloma|Refractory Chronic Lymphocytic Leukemia|Refractory Hodgkin Lymphoma|Waldenstrom Macroglobulinemia October 2003 Phase 3
NCT01526850 Chinese Academy of Medical Sciences|Zhejiang University|Chinese PLA General Hospital|307 Hospital of PLA|Peking Union Medical College Chronic Graft Versus Host Disease February 2012 Phase 2|Phase 3
NCT00260689 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Immunosuppresion|Thrombocytopenia|Pancytopenia|Neutropenia November 28, 2005 Phase 2
NCT00023244 National Institute of Allergy and Infectious Diseases (NIAID)|Cooperative Clinical Trials in Pediatric Transplantation End-Stage Renal Disease January 2001 Phase 2
NCT00483756 Pfizer Kidney Transplantation August 2007 Phase 2
NCT00303719 Masonic Cancer Center, University of Minnesota Kidney Cancer|Leukemia|Lymphoma|Multiple Myeloma|Plasma Cell Neoplasm|Myelodysplastic Syndromes March 26, 2002 Phase 2
NCT00053014 Southwest Oncology Group|National Cancer Institute (NCI) Leukemia April 2003 Phase 2
NCT01043640 Masonic Cancer Center, University of Minnesota Mucopolysaccharidosis|Hurler Syndrome|Hunter Syndrome|Maroteaux-Lamy Syndrome|Sly Syndrome|Alpha Mannosidosis|Fucosidosis|Aspartylglucosaminuria|Adrenoleukodystrophy (ALD)|Krabbe Disease|Metachromatic Leukodystrophy (MLD)|Sphingolipidoses|Peroxisomal Disorders December 2009 Phase 2
NCT00006233 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Melanoma (Skin) January 2000 Phase 2
NCT00309842 Masonic Cancer Center, University of Minnesota Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Myelofibrosis|MDS|Refractory Anemia|Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Non-Hodgkin's Lymphoma|Leukemia|Lymphoma|Multiple Myeloma|Myelodysplastic Syndromes July 2005 Phase 2
NCT01623167 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Aplastic Anemia|Neutropenia|Pancytopenia|Anemia|Thrombocytopenia June 7, 2012 Phase 1|Phase 2
NCT00005113 Boston Children’s Hospital End-Stage Renal Disease|Kidney Transplantation July 1999 Phase 3
NCT00397813 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndrome|Essential Thrombocythemia|Myeloproliferative Neoplasm|Paroxysmal Nocturnal Hemoglobinuria|Polycythemia Vera|Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase|Primary Myelofibrosis|Refractory Anemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Ring Sideroblasts|Refractory Cytopenia With Multilineage Dysplasia|Refractory Cytopenia With Multilineage Dysplasia a January 2006 Phase 2
NCT00014235 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Acute Myeloid Leukemia/Transient Myeloproliferative Disorder|Acute Undifferentiated Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Nas December 2000
NCT00630253 Masonic Cancer Center, University of Minnesota Fanconi Anemia February 17, 2000 Phase 1|Phase 2
NCT02424968 Robert Lowsky|National Cancer Institute (NCI)|Stanford University Acute Myeloid Leukemia|B-Cell Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Hodgkin Lymphoma|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|T-Cell Non-Hodgkin Lymphoma June 2015 Phase 2
NCT00009750 University of California, Davis|National Cancer Institute (NCI) Prostate Cancer March 2001 Phase 1
NCT01177371 Case Comprehensive Cancer Center Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia March 1988 Phase 2
NCT00045305 Eastern Cooperative Oncology Group|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms May 2005 Phase 2
NCT00343798 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI)|Damon Runyon Cancer Research Foundation Accelerated Phase Chronic Myelogenous Leukemia|Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid April 2006 Phase 1
NCT00054353 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Refractory Multiple Myeloma October 2002 Phase 1|Phase 2
NCT01811368 University of California, Davis|Spectrum Pharmaceuticals, Inc Refractory Non Hodgkin Lymphoma|Relapsed Non Hodgkin Lymphoma March 2013 Phase 2
NCT00433277 Semmelweis University Retinitis Pigmentosa
NCT00060424 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) B-Cell Prolymphocytic Leukemia|Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Recurrent Chronic Lymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|T-Cell Prolymphocytic Leukemia March 2003 Phase 2
NCT00038948 Wyeth is now a wholly owned subsidiary of Pfizer Renal Transplantation January 2002 Phase 3
NCT00005799 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|B-cell Chronic Lymphocytic Leukemia|Childhood Acute Lym November 1999
NCT00256750 Bristol-Myers Squibb Kidney Transplantation|Chronic Kidney Failure March 2005 Phase 3
NCT00723099 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Aggressive Non-Hodgkin Lymphoma|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Indolent Non-Hodgkin Lymphoma|Malignant Lymphoma, Large Cell Type|Mixed Phenotype Acute Leukemia|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Recurrent Chronic Lymphocytic Leukemia|Recurrent Follicular Lymphoma|Recurrent Lymphoplasmacytic Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal June 2008 Phase 2
NCT00719888 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Biphenotypic Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia in Remission|Adult Acute Lymphoblastic Leukemia in Complete Remission|Aggressive Non-Hodgkin Lymphoma|Burkitt Lymphoma|Childhood Acute Lymphoblastic Leukemia in Complete Remission|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Lymphoblastic Lymphoma|Mantle Cell Lymphoma|Myelodysplastic Syndrome With Excess Blasts|Myelofibrosis|Pancytopenia|Plasma Cell Myeloma|Pr November 18, 2005 Phase 2
NCT01503242 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Plasma Cell Myeloma|Refractory Plasma Cell Myeloma January 9, 2012 Phase 1
NCT01093586 Case Comprehensive Cancer Center Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Erythroleukemia (M6a)|Adult March 2009 Phase 2
NCT02673008 Nanfang Hospital of Southern Medical University|Sun Yat-sen University Minimal Residual Disease|Donor Lymphocyte Infusion|Hematopoietic Stem Cell Transplantation|Relapse January 2016 Phase 1|Phase 2
NCT00301834 University of California, San Francisco|National Cancer Institute (NCI) Congenital Amegakaryocytic Thrombocytopenia|Diamond-blackfan Anemia|Leukemia|Myelodysplastic Syndromes|Severe Congenital Neutropenia January 2005 Phase 2
NCT00553202 Children's Oncology Group|National Cancer Institute (NCI) Leukemia January 2008 Phase 2
NCT00104858 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage III Small Lymphocytic Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Small Lymphocytic Lymphoma|T-Cell Large Granular Lymphocyte Leukemia December 2004 Phase 2
NCT01300572 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Chronic Myelomonocytic Leukemia|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts|Secondary Acute Myeloid Leukemia January 2012 Phase 1
NCT00000524 University of Utah|National Heart, Lung, and Blood Institute (NHLBI) Cardiovascular Diseases|Heart Diseases|Myocarditis July 1986 Phase 2
NCT01266148 Novartis Pharmaceuticals|Novartis Renal Function and Chronic Allograft Vasculopathy November 2009 Phase 4
NCT01706692 Swiss Dermatology Network for Targeted Therapies Psoriasis July 2011
NCT00796068 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Biphenotypic Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Myelodysplastic Syndrome|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Childhood Myelodysplastic Syndrome|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|RAEB-2|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Refractory Chronic Myelogenous Le October 29, 2008 Phase 2
NCT00594308 Indiana University Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Chronic Lymphocytic Leukemia|Myelodysplasia|Lymphoma, Non-Hodgkin's|Mantle-Cell Lymphoma|Hodgkin's Disease|Multiple Myeloma|Myelofibrosis October 2007
NCT00354172 Masonic Cancer Center, University of Minnesota Leukemia|Myelodysplastic Syndromes February 2006 Phase 2
NCT00578643 Baylor College of Medicine|Texas Children's Hospital Chronic Granulomatous Disease March 2004 Phase 2
NCT00027560 Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms July 2001 Phase 2
NCT00063817 National Institute of Allergy and Infectious Diseases (NIAID)|Immune Tolerance Network (ITN) Kidney Failure|Bone Marrow Transplantation|Kidney Transplantation|Kidney Failure, Chronic June 2003 Phase 1
NCT00547196 City of Hope Medical Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Myelodysplastic Syndromes August 2005
NCT00317876 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Fanconi Anemia June 1998 Phase 1
NCT00686556 Masonic Cancer Center, University of Minnesota Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome|Multiple Myeloma August 2012 Phase 1
NCT00058825 Baylor College of Medicine|Texas Children's Hospital|The Methodist Hospital System Hematologic Malignancies August 2000 Phase 1|Phase 2
NCT01392989 Everett Meyer|Stanford University Neural Tube Defects|Anemia|Leukemia, Myeloid|Bone Marrow Transplant Failure|Myelodysplastic Syndromes (MDS)|Myeloproliferative Disorders March 2011 Phase 2
NCT00003553 National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Kidney Cancer January 1999 Phase 2
NCT01292226 Hoffmann-La Roche Kidney Transplantation December 2006 Phase 2
NCT02274662 M. Louise Markert|Duke University Poor Thymic Function|Immunodeficiency|Athymia|Immunoreconstitution|Thymus Transplantation|Low T Cell Numbers
NCT00185640 Stanford University Blood Cancer|Leukemia March 2003 Phase 2
NCT00350545 Stanford University Graft vs Host Disease|Blood and Marrow Transplant (BMT) August 2006
NCT00520130 National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Myelodysplastic Syndrome|Hodgkin's Lymphoma|Non-Hodgkin's Disease|Acute Leukemia|Multiple Myeloma July 2007 Phase 1|Phase 2
NCT00045435 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid L April 2002 Phase 2
NCT00568633 Stanford University|Genzyme, a Sanofi Company Leukemia, Myeloid|Leukemia|Acute Myeloid Leukemia (AML) August 2007 Phase 3
NCT00129961 Wyeth is now a wholly owned subsidiary of Pfizer Skin Neoplasms|Kidney Transplantation August 2005 Phase 4
NCT00086346 Wyeth is now a wholly owned subsidiary of Pfizer Liver Transplantation December 2002 Phase 3
NCT00027924 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes October 2001 Phase 2
NCT01789255 National Cancer Institute (NCI) Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Grade III Lymphomatoid Granulomatosis|B-cell Chronic Lymphocytic Leukemia|Chronic Myelogenous Leu June 2013 Phase 2
NCT01109498 Amsterdam Molecular Therapeutics|International Antiviral Therapy Evaluation Center Familial Lipoprotein Lipase Deficiency August 2007 Phase 2|Phase 3
NCT00658359 Pfizer Kidney Transplantation August 2008 Phase 2
NCT01962636 Masonic Cancer Center, University of Minnesota Acute Myeloid Leukemia (AML)|Acute Lymphocytic Leukemia (ALL)|Chronic Myelogenous Leukemia|Plasma Cell Leukemia|Myelofibrosis|Myelodysplasia|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Marginal Zone B-Cell Lymphoma|Follicular Lymphoma|Lymphoplasmacytic Lymphoma|Mantle-Cell Lymphoma|Prolymphocytic Leukemia|Diffuse Large B Cell Lymphoma|Lymphoblastic Lymphoma|Burkitt's Lymphoma|Non-Hodgkin Lymphoma|Multiple Myeloma December 2016
NCT00002833 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes October 1994 Phase 2
NCT01175785 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Child August 2010 Phase 2
NCT00378534 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Chronic Myelogenous Leukemia|Acute Myelogenous Leukemia|Chronic Lymphocytic Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome September 2006 Phase 2
NCT00245037 OHSU Knight Cancer Institute|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Precancerous Condition June 2005 Phase 1|Phase 2
NCT00281879 OHSU Knight Cancer Institute|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Unusual Cancers of Childhood February 2006 Phase 2
NCT02707393 St. Anna Kinderkrebsforschung Chronic Myeloid Leukemia April 2009 Phase 2|Phase 3
NCT02867800 Columbia University Sickle Cell Disease|Graft Versus Host Disease July 2016 Phase 1
NCT00357565 Masonic Cancer Center, University of Minnesota Leukemia|Myelodysplastic Syndromes|Childhood Acute Myeloid Leukemia in Remission|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Childhood Acute Lymphoblastic Leukemia in Remission|Previously Treated Myelodysplastic Syndrome|Secondary Myelodysplastic Syndrome|Refractory Anemia With Excess Blasts in Transformation|Refractory Anemia With Excess Blasts|Refractory Anemia|De Novo Myelodysplastic Syndrome|Childhood Myelodysplastic Syndrome December 2005 Phase 2
NCT00119392 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) B-cell Chronic Lymphocytic Leukemia|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphom June 2004 Phase 2
NCT00002832 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes August 1995 Phase 1|Phase 2
NCT00040846 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Dif November 2001 Phase 2
NCT00719849 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases November 2005 Phase 2
NCT00093743 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Childhood Acute Myeloid Leukemia in Remission|Childhood Myelodysplastic Syndromes|Fanconi Anemia|Previously Treated Myelodysplastic Syndromes January 2000 Phase 1
NCT02845596 Andrew Dietz|Children's Hospital Los Angeles Severe Aplastic Anemia August 2016
NCT01252667 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Myeloid Leukemia January 25, 2011 Phase 2
NCT00412360 Medical College of Wisconsin|National Heart, Lung, and Blood Institute (NHLBI)|Blood and Marrow Transplant Clinical Trials Network|National Cancer Institute (NCI)|National Marrow Donor Program Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Myelodysplastic Syndrome|Natural Killer Cell Lymphoblastic Leukemia/Lymphoma December 2006 Phase 3
NCT02653196 Montefiore Medical Center|Children's Hospital Los Angeles|Nationwide Children's Hospital Neuroepithelial Tumor|Solid Tumor|Allogeneic Hematopoietic Stem Cell Transplantation September 2015 Early Phase 1
NCT00036738 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Adult Acute Lymphoblastic Leukemia in Remission|Blastic Phase Chronic Myelogenous Leukemia|Childhood Acute Lymphoblastic Leukemia in Remission|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia|Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia|Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Relapsing Ch July 2001 Phase 2
NCT00243009 OHSU Knight Cancer Institute|National Cancer Institute (NCI) Kidney Cancer June 2005 Phase 2
NCT00571662 University of Nebraska|Astex Pharmaceuticals Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Chronic Lymphocytic Leukemia|Myelodysplastic Syndromes|Multiple Myeloma|Non-Hodgkins Lymphoma|Hodgkins Disease|Peripheral T-Cell Lymphoma December 2000 Phase 2
NCT00816413 University of Nebraska|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Myelodysplastic Syndromes|Nonmalignant Neoplasm September 2008 Phase 1|Phase 2
NCT00354419 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Aplastic Anemia February 2006 Phase 1
NCT02498977 King's College London|King's College Hospital NHS Trust|National Institute for Health Research, United Kingdom Transplantation, Liver October 2015 Phase 4
NCT01231412 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Aggressive Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Diffuse Large B-Cell Lymphoma|Hematopoietic and Lymphoid Cell Neoplasm|Indolent Non-Hodgkin Lymphoma|Mantle Cell Lymphoma|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Prolymphocytic Leukemia|Recurrent Chronic Lymphocytic Leukemia|Recurrent Plasma Cell Myeloma|Refractory Chronic Lymphocytic Leukemia|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Refractory Hodgkin L November 2010 Phase 3
NCT00619645 University of California, Davis Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes June 2007 Phase 2
NCT00891306 Amsterdam Molecular Therapeutics|The Clinical Trial Company Familial Lipoprotein Lipase Deficiency February 2009 Phase 2|Phase 3
NCT00003414 Sidney Kimmel Comprehensive Cancer Center|National Cancer Institute (NCI) Graft Versus Host Disease|Lymphoma October 1997 Phase 3
NCT00383448 Masonic Cancer Center, University of Minnesota Adrenoleukodystrophy|Metachromatic Leukodystrophy|Globoid Cell Leukodystrophy|Tay Sachs Disease|Sandhoffs Disease|Wolman Disease|I-Cell Disease|Sanfilippo Syndrome|GM1 Gangliosidosis September 2006 Phase 2
NCT00987480 Memorial Sloan Kettering Cancer Center|Boston Children’s Hospital|Children's Hospital Medical Center, Cincinnati|Children's Hospital and Health System Foundation, Wisconsin|Rockefeller University|Fred Hutchinson Cancer Research Center Aplastic Anemia|Leukemia|Myelodysplastic Syndrome September 2009 Phase 2
NCT00907036 Cancer Research UK|National Cancer Institute (NCI) Lymphoma July 2009 Phase 2
NCT00988715 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Chronic Myelomonocytic Leukemia|Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts|Refractory Cytopenia With Multilineage Dysplasia|Refractory Cytopenia With Multilineage Dysplasia and Ringed Sideroblasts|Secondary Acute Myeloid Leukemia April 21, 2010 Phase 1
NCT00006055 Fairview University Medical Center|Office of Rare Diseases (ORD) Purpura, Schoenlein-Henoch|Graft Versus Host Disease|Anemia, Hemolytic, Autoimmune|Rheumatoid Arthritis|Churg-Strauss Syndrome|Hypersensitivity Vasculitis|Wegener's Granulomatosis|Systemic Lupus Erythematosus|Giant Cell Arteritis|Pure Red Cell Aplasia|Juvenile Rheumatoid Arthritis|Polyarteritis Nodosa|Autoimmune Thrombocytopenic Purpura|Takayasu Arteritis March 2000
NCT00031655 Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium|National Cancer Institute (NCI)|Fred Hutchinson Cancer Research Center Adult Acute Lymphoblastic Leukemia in Remission|Childhood Acute Lymphoblastic Leukemia in Remission|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia September 2001 Phase 2
NCT00112645 Milton S. Hershey Medical Center|National Cancer Institute (NCI) Neuroblastoma|Sarcoma|Unspecified Childhood Solid Tumor, Protocol Specific April 2005 Phase 1
NCT00609739 Masonic Cancer Center, University of Minnesota Leukemia June 1999 Phase 1|Phase 2
NCT00959231 Cancer Research UK|National Cancer Institute (NCI) Hematopoietic/Lymphoid Cancer January 2009 Phase 2
NCT00574496 Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Lymphoma November 2007 Phase 2
NCT00080925 National Institutes of Health Clinical Center (CC)|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms February 2004 Phase 1
NCT00521430 Asan Medical Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Nonmalignant Neoplasm|Unspecified Adult Solid Tumor, Protocol Specific April 2004
NCT00041288 Simmons Cancer Center|National Cancer Institute (NCI) Leukemia|Lymphoma October 2001 Phase 2
NCT00105235 National Institute of Allergy and Infectious Diseases (NIAID)|Immune Tolerance Network (ITN) Liver Disease|Liver Transplantation June 2005 Phase 2
NCT00008203 Herbert Irving Comprehensive Cancer Center|National Cancer Institute (NCI) Breast Cancer May 1996 Phase 3
NCT01020734 Asan Medical Center Leukemia May 2011 Phase 2
NCT00740467 Institut Paoli-Calmettes|National Cancer Institute (NCI) Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Precancerous Condition January 2008 Phase 2
NCT00436761 Milton S. Hershey Medical Center|National Cancer Institute (NCI) Unspecified Childhood Solid Tumor, Protocol Specific May 2004 Phase 1
NCT00334672 Children's Cancer and Leukaemia Group|National Cancer Institute (NCI) Nonneoplastic Condition March 2006 Phase 3
NCT00544115 City of Hope Medical Center|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases|Precancerous/Nonmalignant Condition September 2001 Phase 2
NCT00534430 City of Hope Medical Center|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes January 2000 Phase 2
NCT00387959 Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Leukemia|Lymphoma July 2006 Phase 2
NCT00006184 National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Multiple Myeloma August 2000 Phase 2
NCT00003954 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma March 1999 Phase 1|Phase 2
NCT00365287 Masonic Cancer Center, University of Minnesota|National Cancer Institute (NCI) Breast Cancer|Kidney Cancer|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes June 2000 Phase 1|Phase 2
NCT00301860 University of California, San Francisco|National Cancer Institute (NCI) Leukemia|Lymphoma January 2003
NCT00550992 Dutch Childhood Oncology Group|BFM Germany|CORS Monza Italy|Associazione Italiana Ematologia Oncologia Pediatrica|Australian and New Zealand Children's Oncology Group|BFM Austria|CLCG France Belgium Portugal|COALL Germany|CPH, Czech republic|DFCI consortium USA|FRALLE France|Hong Kong|MD Anderson USA|NOPHO Scandinavian countries|PINDA, Chile|PPLLSG Poland|Seattle USA|SJCRH USA|UKCCSG United Kingdom Leukemia June 2007
NCT00376519 Masonic Cancer Center, University of Minnesota Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Secondary Myelofibrosis May 2007 Phase 1
NCT00110058 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia February 2005 Phase 2
NCT00027820 Fred Hutchinson Cancer Research Center|National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Adult Acute Myeloid Leukemia in Remission|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Childhood Myelodysplastic Syndrome|Childhood Renal Cell Carcinoma|Chronic Myelomonocytic Leukemia|Clear Cell Renal Cell Carcinoma|de Novo Myelodysplastic Syndrome|Metastatic Renal Cell Cancer|Previously Treated Myelodysplastic Syndrome|Progression of Multiple Myeloma or Plasma Cell Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute M August 2001 Phase 1|Phase 2
NCT00074269 University of California, San Diego|National Cancer Institute (NCI) Breast Cancer July 2003 Phase 2
NCT00425802 Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Leukemia|Lymphoma November 28, 2006 Phase 2
NCT01427881 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Myeloid Leukemia in Remission|Adult Erythroleukemia (M6a)|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Adult Pure Erythroid Leukemia (M6b)|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Acute Erythroleukemia (M6)|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood A September 2011 Phase 2
NCT00908180 Cancer Research UK|National Cancer Institute (NCI) Lymphoma July 2009 Phase 2
NCT00281983 German CLL Study Group Chronic Lymphocytic Leukemia June 2000 Phase 1|Phase 2
NCT00043979 National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Sarcoma September 19, 2002 Phase 2
NCT01954784 Case Comprehensive Cancer Center|National Cancer Institute (NCI) Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma October 7, 2013 Phase 1
NCT00005851 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer February 2000 Phase 1|Phase 2
NCT00005940 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) October 1999 Phase 2
NCT01685411 Masonic Cancer Center, University of Minnesota Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndrome January 2013
NCT01626092 Masonic Cancer Center, University of Minnesota Lysosomal Storage Disease|Peroxisomal Disorder July 11, 2012
NCT03128034 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia in Remission|CD45-Positive Neoplastic Cells Present|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome With Excess Blasts|Recurrent Adult Acute Myeloid Leukemia|Refractory Adult Acute Lymphoblastic Leukemia August 19, 2017 Phase 1|Phase 2
NCT01434472 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Post-Transplant Lymphoproliferative Disorder|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma|Recurrent Burkitt Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Burkitt Lymphoma|Refractory Diffuse Large B-Cell Lymphoma November 16, 2011 Phase 2
NCT01690520 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) Acute Biphenotypic Leukemia|Acute Erythroid Leukemia|Acute Lymphoblastic Leukemia in Remission|Acute Megakaryoblastic Leukemia|Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Acute Myeloid Leukemia in Remission|Blasts Under 10 Percent of Bone Marrow Nucleated Cells|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Mixed Phenotype Acute Leukemia|Myelodysplastic Syndrome|Myelodysplastic Syndrome With Excess Blasts|Pancytopenia|Refractory Anemia|Secondary Acute Myeloid Leukemia December 11, 2012 Phase 2
NCT02461121 The Affiliated Hospital of the Chinese Academy of Military Medical Sciences Acute Myeloid Leukemia May 2004 Phase 3
NCT00789308 National Institute of Allergy and Infectious Diseases (NIAID)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Clinical Islet Transplantation Consortium Diabetes Mellitus, Type I July 2008 Phase 2
NCT02756572 University of Washington|National Cancer Institute (NCI) Chronic Myelomonocytic Leukemia-2|High Grade Malignant Neoplasm|Myeloid Neoplasm|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia September 22, 2016
NCT00553098 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) Immunodeficiency Syndrome|Non-Cancer Diagnosis June 2006 Phase 2
NCT00337493 Hoffmann-La Roche Kidney Transplantation December 2005 Phase 4
NCT01810926 Franco Locatelli|University of Milano Bicocca|medac GmbH|Fresenius AG|Bambino Gesù Hospital and Research Institute Graft Versus Host Disease September 2011 Phase 2
NCT01105650 Masonic Cancer Center, University of Minnesota Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer|Breast Cancer July 2010 Phase 2
NCT02435901 Northwell Health Sickle Cell Disease|Beta Thalassemia-Major December 2008 Phase 1|Phase 2
NCT00322101 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Acute Myeloid Leukemia/Transient Myeloproliferative Disorder|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Chi January 2006 Phase 3
NCT00579527 M. Louise Markert|National Institutes of Health (NIH)|National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University DiGeorge Anomaly|Complete DiGeorge Anomaly|Complete Atypical DiGeorge Anomaly|Complete DiGeorge Syndrome|Complete Atypical DiGeorge Syndrome March 2006 Phase 1|Phase 2
NCT00919503 Fred Hutchinson Cancer Research Center|medac GmbH|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) Non-Malignant July 31, 2009 Phase 2
NCT00031824 Children's Oncology Group|National Cancer Institute (NCI) Graft Versus Host Disease April 2002 Phase 3
NCT00004485 Fred Hutchinson Cancer Research Center|Office of Rare Diseases (ORD) Sickle Cell Anemia December 1999 Phase 1|Phase 2
NCT00006968 Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) Kidney Cancer September 2000 Phase 1|Phase 2
NCT00636909 Beth Israel Deaconess Medical Center|Amgen AML|ALL|CML Chronic Phase, Accelerated Phase, or Blast Crisis|CLL|MDS|RELAPSED NON-HODGKIN'S OR HODGKIN'S LYMPHOMA|APLASTIC ANEMIA|MULTIPLE MYELOMA|MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET) July 1999 Phase 2
NCT00795132 University of Utah Acute Leukaemia|Chronic Disease|Leukemia|Myelodysplasia|Lymphoma April 2004 Phase 2
NCT01062555 University of Minnesota - Clinical and Translational Science Institute|Roche Pharma AG|Wyeth is now a wholly owned subsidiary of Pfizer|Genzyme, a Sanofi Company CNI Side Effects October 2006 Phase 1|Phase 2
NCT00003116 Case Comprehensive Cancer Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases May 1997 Phase 2
NCT02416388 University Hospital, Angers Acute Myeloid Leukemia (AML) January 2015 Phase 2|Phase 3
NCT00784719 Pfizer Dry Eye Syndromes November 2008 Phase 1|Phase 2
NCT00002831 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Leukemia July 1994 Phase 1|Phase 2
NCT00874315 Nationwide Children's Hospital Neuroblastoma September 2008 Phase 2
NCT00049634 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases January 2002 Phase 1|Phase 2
NCT00481832 Stanford University Lymphoma, Non-Hodgkin January 2007 Phase 2
NCT00790439 National Institute of Allergy and Infectious Diseases (NIAID)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes Mellitus, Type I July 2008 Phase 2
NCT00002547 Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes August 1987 Phase 2
NCT00005854 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes December 1999 Phase 2
NCT00024128 AIDS Malignancy Consortium|National Cancer Institute (NCI) Lymphoma August 2001 Phase 2
NCT00793572 Fred Hutchinson Cancer Research Center|Millennium Pharmaceuticals, Inc.|National Cancer Institute (NCI) Refractory Plasma Cell Myeloma October 2008 Phase 2
NCT00150891 University of Giessen|Heidelberg University|Astellas Pharma Inc|Novartis|Fresenius AG|Hoffmann-La Roche|Biotest Renal Failure, Chronic January 1998
NCT01786018 Azienda Ospedaliera San Giovanni Battista B-cell Lymphoma Refractory February 2013 Phase 2
NCT00017654 Northwestern Memorial Hospital|Office of Rare Diseases (ORD) Graft Versus Host Disease|Aplastic Anemia April 2001
NCT01446484 Pirogov Russian National Research Medical University|Russian Academy of Medical Sciences End-Stage Renal Disease|Kidney Failure October 2011 Phase 1|Phase 2
NCT00002961 Children's Hospital of Philadelphia Leukemia October 1995 Phase 3
NCT00003335 Case Comprehensive Cancer Center|National Cancer Institute (NCI) Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases January 1998 Phase 2
NCT00068523 Case Comprehensive Cancer Center|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases June 2003
NCT00056095 UNICANCER|National Cancer Institute (NCI) Kidney Cancer December 2002 Phase 2
NCT00185692 Stanford University Blood Cancer|Leukemia|Graft Versus Host Disease|Malignancy|CLL|NHL|Hodgkin's Disease|MDS August 2000 Phase 2
NCT00024050 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes February 2001 Phase 2
NCT00005866 Southwest Oncology Group|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes February 2000 Phase 3
NCT00002789 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia May 1996 Phase 3
NCT00020176 National Cancer Institute (NCI) Breast Cancer June 2000 Phase 2
NCT00003060 Feist-Weiller Cancer Center at Louisiana State University Health Sciences|National Cancer Institute (NCI) Melanoma (Skin) March 1995 Phase 1
NCT01220531 M. Louise Markert|National Institutes of Health (NIH)|National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Enzyvant Therapeutics GmbH|Duke University Complete DiGeorge Anomaly|DiGeorge Syndrome|DiGeorge Anomaly|Complete DiGeorge Syndrome December 2010
NCT00022737 National Cancer Institute (NCI) Childhood Acute Lymphoblastic Leukemia in Remission|Recurrent Childhood Acute Lymphoblastic Leukemia October 2002 Phase 3
NCT00899847 Stanford University Transplantation, Homologous|Transplantation, Autologous|Multiple Myeloma|Blood and Marrow Transplant (BMT) May 2009 Phase 2
NCT00014508 Eastern Cooperative Oncology Group|National Cancer Institute (NCI) Multiple Myeloma and Plasma Cell Neoplasm April 2001 Phase 2
NCT01527045 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI)|National Heart, Lung, and Blood Institute (NHLBI) Aggressive Non-Hodgkin Lymphoma|Myelodysplastic/Myeloproliferative Neoplasm|Non-Hodgkin Lymphoma|Prolymphocytic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Aggressive Adult Non-Hodgkin Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Chronic Lymphocytic Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent Diffuse Large B-Cell Lymphoma|Recurrent Hodgkin September 2012 Phase 2
NCT00029380 National Heart, Lung, and Blood Institute (NHLBI) Hematologic Diseases|Anemia, Sickle Cell|Beta-Thalassemia|Hematopoietic Stem Cell Transplantation January 1999 Phase 2
NCT00081055 Mesoblast International Sàrl|National Cancer Institute (NCI)|Mesoblast, Ltd. Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes Phase 2
NCT00005803 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Prolymphocytic Leukemia|Recurrent Adult Hodgkin Lymphoma|Recurrent Childhood Hodgkin Lymphoma|Recurrent Childhood Non-Hodgkin Lymphoma|Recurrent Chronic Lymphocytic Leukemia|Recurrent Non-Hodgkin Lymphoma|Recurrent Small Lymphocytic Lymphoma|Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma|Refractory Small Lymphocytic Lymphoma|T-Cell Chronic Lymphocytic Leukemia|T-Cell Prolymphocytic Leukemia September 1999 Phase 1|Phase 2
NCT00004232 Northwestern University|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Precancerous/Nonmalignant Condition October 1999 Phase 1
NCT00005898 University of Minnesota - Clinical and Translational Science Institute|Office of Rare Diseases (ORD) Fanconi's Anemia February 2000 Phase 1|Phase 2
NCT00004323 National Center for Research Resources (NCRR)|University of California, Los Angeles Aplastic Anemia February 1995 Phase 2
NCT00002792 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic/Myeloproliferative Diseases June 1996 Phase 2
NCT00054340 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases October 2002 Phase 1|Phase 2
NCT00008151 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes October 2000 Phase 2
NCT00066417 National Heart, Lung, and Blood Institute (NHLBI)|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic/Myeloproliferative Diseases Phase 2
NCT00005988 Dana-Farber Cancer Institute|National Cancer Institute (NCI) Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Myeloma February 2000 Phase 1
NCT00003661 Roswell Park Cancer Institute Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Neuroblastoma June 1998 Phase 2
NCT00317785 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Myelodysplastic Syndromes May 2005 Phase 2
NCT00044954 Simmons Cancer Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases November 2001 Phase 2
NCT00027547 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia July 2001 Phase 1|Phase 2
NCT00008307 Herbert Irving Comprehensive Cancer Center|National Cancer Institute (NCI) Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes April 1998 Phase 2
NCT00006451 Masonic Cancer Center, University of Minnesota Graft Versus Host Disease|Leukemia|Lymphoma April 1996 Phase 3
NCT00003187 Virginia Commonwealth University|National Cancer Institute (NCI) Leukemia|Lymphoma|Myelodysplastic Syndromes May 1995 Phase 2|Phase 3
NCT00290628 Masonic Cancer Center, University of Minnesota|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Diamond-blackfan Anemia|Fanconi Anemia|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases October 1999
NCT00003662 Roswell Park Cancer Institute|National Cancer Institute (NCI) Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes|Thymic Carcinoma August 1998 Phase 2
NCT00022126 Children's Oncology Group|National Cancer Institute (NCI) Leukemia November 2002 Phase 2
NCT00253552 OHSU Knight Cancer Institute|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases|Sarcoma May 2004
NCT00006056 Fairview University Medical Center|Office of Rare Diseases (ORD) Chediak-Higashi Syndrome|Graft Versus Host Disease|X-Linked Lymphoproliferative Syndrome|Familial Erythrophagocytic Lymphohistiocytosis|Hemophagocytic Lymphohistiocytosis|Virus-Associated Hemophagocytic Syndrome March 2000
NCT00006054 Fairview University Medical Center|Office of Rare Diseases (ORD) Immunologic Deficiency Syndromes|Chediak-Higashi Syndrome|Common Variable Immunodeficiency|Graft Versus Host Disease|X-Linked Lymphoproliferative Syndrome|Familial Erythrophagocytic Lymphohistiocytosis|Hemophagocytic Lymphohistiocytosis|X-linked Agammaglobulinemia|Wiskott-Aldrich Syndrome|Chronic Granulomatous Disease|X-linked Hyper IgM Syndrome|Severe Combined Immunodeficiency|Leukocyte Adhesion Deficiency Syndrome|Virus-Associated Hemophagocytic Syndrome March 2000
NCT00005641 H. Lee Moffitt Cancer Center and Research Institute|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes September 1997 Phase 2
NCT00055653 Roswell Park Cancer Institute|National Heart, Lung, and Blood Institute (NHLBI) Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic-Myeloproliferative Diseases January 2003 Phase 2
NCT00005852 H. Lee Moffitt Cancer Center and Research Institute|National Cancer Institute (NCI) Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes June 1996 Phase 2
NCT00003270 Roswell Park Cancer Institute Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes September 4, 1997 Phase 2
NCT00070174 Children's Oncology Group|National Cancer Institute (NCI) Leukemia December 2003 Phase 2
NCT00002761 Columbia University Leukemia February 1996 Phase 1|Phase 2
NCT00002785 Children's Oncology Group|National Cancer Institute (NCI) Leukemia July 1996 Phase 2
NCT00317408 European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma|National Cancer Institute (NCI) Lymphoma April 2004
NCT01033552 Masonic Cancer Center, University of Minnesota Epidermolysis Bullosa January 2010 Phase 2
NCT02665065 Actinium Pharmaceuticals Acute Myeloid Leukemia|Leukemia, Acute Myeloid|Myeloid Leukemia, Acute|Leukemia, Myeloid, Acute|Acute Myelogenous Leukemia|Leukemia, Acute Myelogenous|Myelogenous Leukemia, Acute June 2016 Phase 3
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 0.8315 mL 4.1576 mL 8.3152 mL
5 mM 0.1663 mL 0.8315 mL 1.6630 mL
10 mM 0.0832 mL 0.4158 mL 0.8315 mL
Kinase Assay
[3]

Reaction mixtures with purified enzyme contains 100 nM calcineurin, 100 nM calmodulin, and 5 μM 32P-labeled phosphopeptide, in 60 μL (total volume) of assay buffer containing 20 mM Tris (pH 8), 100 mM NaCl, 6 mM MgCl2, 0.5 mM dithiothreitol, 0.1 mg of bovine serum albumin per mL, and either 0.1 mM CaCl2 or 5 mM EGTA. Reaction mixtures with cell lysates contains 20 μL of undiluted lysate, 5 μM 32P-labeled phosphopeptide, and 40 μL of assay buffer. Reaction mixtures contains 50 μM peptide 412 or 413 and/or 500 nM okadaic acid, a specific inhibitor of phosphatases 1 and 2A; 500 nM okadaic acid is sufficient for inhibition of Ca2+-independent phosphatases, whereas higher concentrations partially inhibit Ca2+-dependent activity as well. After 15 min at 30°C, reactions are terminated by the addition of 0.5 mL of 100 mM potassium phosphate buffer (pH 7.0) containing 5% trichloroacetic acid. Free inorganic phosphate is isolated by Dowex cation-exchange chromatography and quantitated by scintillation counting as described. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Assay
[3]

Cyclosporin A is dissolved in ethanol.

Immunosuppressive agents are dissolved in ethanol at concentrations 1000-fold more than the concentration desired for cell treatments. Cells (106) are suspended in 1 mL of complete medium in microcentrifuge tubes; 1 μL of ethanol or of the ethanolic solution of Cyclosporin A is added, and the cells are incubated at 37°C for 1 hr. Cells are washed twice with 1 mL of PBS on ice and lysed in 50 μL of hypotonic buffer containing 50 mM Tris (pH 7.5); 0.1 mM EGTA; 1 mM EDTA; 0.5 mM dithiothreitol; and 50 μg of phenylmethylsulfonyl fluoride, 50 μg of soybean trypsin inhibitor, 5 μg of leupeptin, and 5 μg of aprotinin per mL. Lysates are subjected to three cycles of freezing in liquid nitrogen followed by thawing at 30°C and then are centrifuged at 4°C for 10 min at 12,000×g. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[6]

Cyclosporin A is suspended in 0.5% solution of tragacanth.

Rats are immunized on day 0 i.p. with 0 5 mL and mice i.v. with 0 2 mL of a 10% suspension of washed sheep erythrocytes (SE). To elicit a secondary response, mice are boosted 8-11 weeks after the primary immunization with an i.v. injection of 0-2 mL of 0 25% washed SE (107 cells). For prolonged treatment the animals receive on the average 45 mg/kg cyclosporin A daily in the food during 13 weeks. These rats are immunized 5 days before killing. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1202.61

Formula

C₆₂H₁₁₁N₁₁O₁₂

CAS No.

59865-13-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Cyclosporin A
Cat. No.:
HY-B0579
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