Cat. No.: HY-L081

Phosphatase Inhibitor Library

87 Cited Publications

Customer Review

Based on 87 publication(s) in Google Scholar

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 181 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (87)
Documentation
Composition

Description & Advantages

• A unique collection of 181 phosphatase inhibitors for high throughput screening (HTS) and high content screening (HCS).

• The library contains compounds targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases (PP1, PP2A, and PP2B, etc.).

• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

• Structurally diverse, medicinally active, and cell permeable.

• Rich documentation with structure, IC₅₀, and customer reviews.

• NMR and HPLC validated to ensure high purity.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 181 phosphatase inhibitors supplied as pre-dissolved Solutions or Solid

Solution: 175 compounds supplied in 10 mM solution, 4 compounds supplied in 2 mM solution, 2 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice