1. Stem Cell/Wnt
  2. Porcupine

Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Porcupine Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-17545
    LGK974 Inhibitor
    LGK974 is a potent and specific small-molecule Porcupine (PORCN) inhibitor, also potently inhibits Wnt signaling in the aforementioned Wnt coculture assay with an IC50 of 0.4 nM.
  • HY-15659
    Wnt-C59 Inhibitor
    Wnt-C59 is a potent PORCN enzymatic activity and Wnt inhibitor.
  • HY-100408
    GNF-6231 Inhibitor
    GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
  • HY-15825
    IWP L6 Inhibitor
    IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM.