1. Stem Cell/Wnt
  2. Porcupine
  3. IWP L6

IWP L6 (Synonyms: Porcn Inhibitor III)

Cat. No.: HY-15825 Purity: 99.78%
Handling Instructions

IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC50 of 0.5 nM.

For research use only. We do not sell to patients.

IWP L6 Chemical Structure

IWP L6 Chemical Structure

CAS No. : 1427782-89-5

Size Price Stock Quantity
10 mg USD 85 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 540 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC50 of 0.5 nM.

IC50 & Target

EC50 Value: 0.5 nM[1]

In Vitro

IWP-L6 (Porcn Inhibitor III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IWP-L6 (Porcn Inhibitor III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

472.58

Formula

C₂₅H₂₀N₄O₂S₂

CAS No.

1427782-89-5

SMILES

O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1.43 mg/mL (3.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1160 mL 10.5802 mL 21.1604 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

IWP L6Porcn Inhibitor IIIIWP L 6IWP L-6PorcupineInhibitorinhibitorinhibit

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IWP L6
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HY-15825
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