Signaling Pathway

Imidazoline Receptor

Imidazoline Receptor

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Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor – an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor – regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.

Imidazoline Receptor Inhibitors & Modulators (2)

Product Name Catalog No. Brief Description
Moxonidine

HY-B0374

Moxonidine is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.

Moxonidine hydrochloride

HY-B0374A

Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.