2. Signaling Pathways
  3. Immunology/Inflammation
  4. AP-1
  5. c-Fos Isoform

c-Fos

c-Fos is an immediate-early gene product and transcription factor that functions as a central mediator of stimulus-dependent gene expression, linking transient extracellular signals to long-term cellular responses through regulation of downstream target genes[1]. Mechanistically, c-Fos belongs to the Fos family and forms the activator protein-1 (AP-1) transcription factor complex through dimerization with Jun family proteins, thereby regulating genes involved in cellular differentiation, proliferation, development, plasticity, and survival[4][5][2]. c-Fos expression is rapidly induced by neuronal activity, calcium- and cAMP-dependent signaling, and other environmental stimuli, making it a widely used molecular marker of cellular activation and stimulus-transcription coupling in experimental systems[1][6][3]. In disease and experimental models, c-Fos has been extensively employed to map activated neuronal populations during seizures, learning, memory formation, and behavioral responses, providing a framework for investigating neural circuit function and activity-dependent transcriptional programs[6][3]. Compared with related Fos family members, including FosB, Fra-1 (FOSL1), and Fra-2 (FOSL2), c-Fos contains a C-terminal transactivation domain and exhibits distinctive transcriptional regulatory properties within AP-1 complexes[4]. For experimental applications, c-Fos is primarily used as an activity-dependent biomarker rather than a direct pharmacological target, enabling quantitative assessment of cellular activation, neural network recruitment, and stimulus-responsive signaling pathways in neuroscience and molecular biology research[3][7].

c-Fos Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-12270
    T-5224
    		Inhibitor 99.59%
    T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
  • HY-168895
    c-Fos-IN-1
    		Inhibitor
    c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth.
  • HY-116640
    Amorphigenin
    		Inhibitor
    Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders.