2. Immunology/Inflammation PI3K/Akt/mTOR Epigenetics Autophagy
  3. AP-1 Nuclear Factor of activated T Cells (NFAT) AMPK Autophagy
  4. Amorphigenin

Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders.

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Amorphigenin

Amorphigenin Chemical Structure

CAS No. : 4208-09-7

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Amorphigenin Related Antibodies

Top Publications Citing Use of Products

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c-Fos FosB Fra1/FOSL1 Fra2/FOSL2 c-Jun

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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Description

Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders[1][2].

IC50 & Target[1]

c-Fos

 

Molecular Weight

410.42

Formula

C23H22O7
CAS No.
SMILES

O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(CO)=C)COC5=C2C=C(C(OC)=C5)OC)[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Amorphigenin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amorphigenin4208-09-7AP-1Nuclear Factor of activated T Cells (NFAT)AMPKAutophagyActivator Protein 1AMP-activated protein kinaseOsteoclastMelanosome degradationNFATc1DepigmentationBone lossInhibitorinhibitorinhibit

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