1. Signaling Pathways
  2. Stem Cell/Wnt
    TGF-beta/Smad
  3. TGF-beta/Smad

TGF-beta/Smad

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

TGF-beta/Smad Related Products (12):

Cat. No. Product Name Effect Purity
  • HY-B0673
    Pirfenidone Inhibitor 99.98%
    Pirfenidone is a drug used for the treatment of idiopathic pulmonary fibrosis. It inhibits FGFR, EGFR, PDGFR, TGF-β, thereby slowing tumor cell proliferation.
  • HY-13013
    SIS3 Inhibitor >98.0%
    SIS3 is a cell-permeable and selective inhibitor of Smad3. It inhibits Smad3 phosphorylation with an IC50 of 3 µM.
  • HY-100347A
    SRI-011381 hydrochloride Agonist 99.78%
    SRI-011381 (hydrochloride) is a TGF-beta signaling agonist, with neuroprotective.
  • HY-16268
    Kartogenin Activator 98.34%
    Kartogenin is an inducer of differentiation of human mesenchymal stem cells into chondrocytes.
  • HY-P0118
    Disitertide Inhibitor 98.12%
    Disitertide is an inhibitor of TGF-β1.
  • HY-N1584
    Halofuginone Inhibitor 98.32%
    Halofuginone (RU-19110) is a less-toxic form of Febrifugine, which is isolated from the plant Dichroa febrifuga. Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity.
  • HY-N0158
    Oxymatrine Inhibitor >98.0%
    Oxymatrine, an alkaloid from the roots of Sophora species, with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway.
  • HY-N0439
    Asiaticoside Modulator 98.46%
    Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.
  • HY-101275
    EMT inhibitor-1 Inhibitor 98.71%
    EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
  • HY-B0252
    Hydrochlorothiazide Inhibitor 99.20%
    Hydrochlorothiazide is a diuretic drug of the thiazide class.
  • HY-N1584A
    Halofuginone hydrobromide Inhibitor 99.94%
    Halofuginone hydrobromide (RU-19110 hydrobromide) is a less-toxic form of Febrifugine, which is isolated from the plant Dichroa febrifuga. Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity.
  • HY-N2033
    Chebulinic acid Inhibitor
    Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.
Isoform Specific Products

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