2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. CCL12

CCL12

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CCL12, also known as monocyte chemotactic protein 5 (MCP-5), belongs to the CC chemokine cluster on mouse chromosome 11. CCL12 is a potent peripheral blood mononuclear cell chemokine that attracts eosinophils, monocytes and lymphocytes but not neutrophils. It induces calcium flux in peripheral blood mononuclear cells, but not in purified mouse eosinophils or neutrophils. CCL12 is a potent monocyte-active chemokine that signals through CCR2. Involved in allergic inflammation and host response to pathogens, and may play a key role in the early stages of allergic pulmonary inflammation[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7246
    MCP-5/CCL12 Protein, Mouse (CHO)

    rMuMCP-5/CCL12; C-C motif chemokine 12; MCP5; SCYA12

    		Mouse CHO
    MCP-5/CCL12 protein, Mouse (CHO) is a potent monocyte-active chemokine that binds to the CCR2 chemokine receptor and is involved in allergic inflammation and host responses to pathogens. MCP-5/CCL12 protein, Mouse (CHO) is a recombinant mouse MCP-5/CCL12 (G23-G104) expressed by CHO.
  • HY-P700266
    MCP-5/CCL12 Protein, Mouse (P. pastoris, His)

    rMuMCP-5/CCL12; C-C motif chemokine 12; MCP5; SCYA12

    		Mouse P. pastoris
    MCP-5/CCL12 protein promotes CCR2 chemokine receptor binding and contributes to physiological processes such as angiogenesis, inflammation, and monocyte chemotaxis. It is located extracellularly and is widely expressed in tissues such as the central nervous system. MCP-5/CCL12 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived MCP-5/CCL12 protein, expressed by P. pastoris , with C-His labeled tag. The total length of MCP-5/CCL12 Protein, Mouse (P. pastoris, His) is 82 a.a., with molecular weight of ~10.7 KDa.
  • HY-P71903
    MCP-5/CCL12 Protein, Rat

    C-C motif chemokine; CCL12

    		Rat E. coli
    The MCP-5/CCL12 protein belongs to the intercrine beta family and is essential for chemokines involved in intercellular communication and immune responses. In this family, MCP-5/CCL12 may play a role in regulating inflammatory processes and cellular interactions. MCP-5/CCL12 Protein, Rat is the recombinant rat-derived MCP-5/CCL12 protein, expressed by E. coli , with tag free. The total length of MCP-5/CCL12 Protein, Rat is 68 a.a., with molecular weight of ~7.9 kDa.
Cat. No. Product Name Effect Purity