CCL12
CCL12, also known as monocyte chemotactic protein 5 (MCP-5), belongs to the CC chemokine cluster on mouse chromosome 11. CCL12 is a potent peripheral blood mononuclear cell chemokine that attracts eosinophils, monocytes and lymphocytes but not neutrophils. It induces calcium flux in peripheral blood mononuclear cells, but not in purified mouse eosinophils or neutrophils. CCL12 is a potent monocyte-active chemokine that signals through CCR2. Involved in allergic inflammation and host response to pathogens, and may play a key role in the early stages of allergic pulmonary inflammation[1][2].
- [1]. [1] Sarafi MN,et al. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997 Jan 6;185(1):99-109. [Content Brief]
- [2]. She S, et al. Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease. Front Immunol. 2022 Feb 25;13:812431.
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CCL12 Recombinant Proteins (2)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
