2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Amphiregulin

Amphiregulin

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Amphiregulin (AREG) is an epidermal growth factor (EGF)-like molecule and is classified into the EGF family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. AREG gene expression and release is induced by a plethora of stimuli including inflammatory lipids, cytokines, hormones, growth factors and xenobiotics. Through EGFR binding AREG activates the generation of intracellular signals modulating cell proliferation, apoptosis and migration of different cell types including epithelial cells, fibroblasts and immune cells (dendritic cells, neutrophils, mast cells and lymphocytes). Physiologically, AREG plays an important role in lung morphogenesis and the development and maturation of mammary glands, bone tissue and oocytes. AREG also plays a critical role in restoring tissue integrity following infection or injury.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7002
    Amphiregulin Protein, Human (HEK293)

    rHuAmphiregulin; AR; AREG; Colorectum cell-derived growth factor; CRDGF

    		Human HEK293
    Amphiregulin Protein, Human (HEK293, His) is an EGF receptor (EGFR) ligand, and essential for epithelial development in various organs.
  • HY-P70578
    Amphiregulin Protein, Human

    Amphiregulin; AR; Colorectum Cell-Derived Growth Factor; CRDGF; AREG; SDGF; AREGB

    		Human E. coli
    Amphiregulin Protein, an EGFR ligand, serves as an autocrine growth factor and mitogen for various cells, including astrocytes, Schwann cells, and fibroblasts. It promotes cellular proliferation and interacts with CNIH in its immature precursor stage. Amphiregulin's EGFR activation underscores its role in essential cellular processes, emphasizing its significance as a regulator of cell growth and function in diverse cell types. Amphiregulin Protein, Human is the recombinant human-derived Amphiregulin protein, expressed by E. coli , with tag free. The total length of Amphiregulin Protein, Human is 98 a.a., with molecular weight of 14-16 kDa.
  • HY-P77868
    Amphiregulin Protein, Mouse (HEK293, Fc)

    Amphiregulin; AR; SDGF; AREG; AREGB; CRDGF; MGC13647

    		Mouse HEK293
    Amphiregulin Protein, an EGFR ligand, acts as an autocrine growth factor and mitogen for diverse cells, including astrocytes, Schwann cells, and fibroblasts. Engaging with CNIH in its immature stage, Amphiregulin's EGFR activation emphasizes its vital role in regulating cell growth and orchestrating various cellular functions across different cell types. Amphiregulin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Amphiregulin protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Amphiregulin Protein, Mouse (HEK293, Fc) is 149 a.a., with molecular weight of 45-50 kDa.
Cat. No. Product Name Effect Purity