Carboxypeptidase
Carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of aprotein or peptide. Contrast with an aminopeptidase, which cleaves peptide bonds at the other end of the protein. Humans, animals, and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation. Carboxypeptidases function involved in the indigestion of food, biosynthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing, reproduction, and many other processes.
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Carboxypeptidase Related Products (34)
Related Products (34)
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Recombinant Proteins (42)
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Antibodies (1)
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2-PMPA
0 ImagesSynonyms: 2-(Phosphonomethyl)pentanedioic acid2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA is applicable to the research of neurological diseases.
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CPA inhibitor
0 ImagesSynonyms: Carboxypeptidase inhibitorCPA inhibitor (Compound 5) (Carboxypeptidase inhibitor) is an orally active competitive carboxypeptidase A (CPA) inhibitor with a Ki value of 0.32 μM. CPA inhibitor blocks the activity of carboxypeptidase A3 (CPA3). CPA activator activates the Wnt/Lrp6/β-catenin signaling pathway. CPA inhibitor reduces epithelial damage. CPA inhibitor is applicable to research related to inflammatory bowel disease, including ulcerative colitis and Crohn's disease.
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D-Dopa
0 ImagesSynonyms: 3-Hydroxy-D-tyrosineD-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research.
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Mergetpa
0 ImagesCat. No.: HY-W704574CAS No.: 77102-28-4Mergetpa is a reversible Arg-carboxypeptidase inhibitor with high affinity. Mergetpa reduces B1R. Mergetpa blocks the overexpression of IL-1β protein and mRNA in glucose-fed rats. Mergetpa significantly increases the expression of IL-1β protein in the renal cortex. Mergetpa is used to block the conversion of kinins and B2 receptor antagonists into metabolites lacking the C-terminal arginine. Mergetpa inhibits the time-dependent enhancement of the response of isolated rabbit aorta to bradykinin. Mergetpa preserves the chemotactic activity of full-length SDF-1α on cells. Mergetpa reverses hyperglycemia, excessive weight gain, elevated levels of oxidative stress markers and overexpression of inflammatory markers in glucose-fed rats.
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2-Benzylsuccinic acid
0 ImagesSynonyms: DL-Benzylsuccinic acid2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis.
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E2072
0 ImagesCat. No.: HY-165571CAS No.: 378242-00-3E2072 is a selective, orally active competitive inhibitor of glutamate carboxypeptidase II (GCPII) with a Ki of 10 nM. E2072 alleviates established thermal hyperalgesia in a rat model of chronic constriction injury. E2072 prevents oxaliplatin-induced reductions in nerve conduction velocity and amplitude in mice. E2072 is applicable to research related to neuropathic pain and neuropathy.
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Tyromycin A
0 ImagesCat. No.: HY-N19639CAS No.: 141364-77-4Tyromycin A is an inhibitor targeting Leu-AP, Cys-AP and CP-A, with an IC50 value of 25-41 μg/mL against porcine Leu-AP and an IC50 value of 60 μg/mL against bovine CP-A. Tyromycin A inhibits the hydrolytic activity of target peptidases and exhibits selective activity against Gram-positive bacteria. Tyromycin A moderately inhibits the infectivity of HCV in human hepatocytes, with an IC50 of 6.6 μM, and its inhibitory activity depends on the two maleic anhydride domains. Tyromycin A can be used in studies related to Gram-positive bacterial infections and hepatitis C virus infections.
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Carboxypeptidase-B rat
0 ImagesCat. No.: HY-P2746ACarboxypeptidase-B rat (EC 3.4.17.2) catalyzes the hydrolysis of the basic amino acids, lysine, arginine, and ornithine from the C-terminal position of polypeptides. Carboxypeptidase-B rat (EC 3.4.17.2) may be used for sequence analysis by successive cleavage of C-terminal basic amino acids.
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Hippuryl-L-phenylalanine
0 ImagesHippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity.
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2-MPPA
0 ImagesSynonyms: GPI-56932-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM.
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2-PMPA sodium
0 ImagesSynonyms: 2-(Phosphonomethyl)pentanedioic acid sodium2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases.
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Dansyl-Ala-Arg
0 ImagesDansyl-Ala-Arg is a synthetic peptide. Dansyl-Ala-Arg can be used for various biochemical studies.
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Carboxypeptidase C
0 ImagesCarboxypeptidase C is a carboxypeptidase, is often used in biochemical studies. Carboxypeptidase C removes COOH-terminal lysine, arginine, and proline, as well as all other neutral, aliphatic, aromatic, and the acidic protein amino acids of a peptide chain.
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GEMSA
0 ImagesSynonyms: 2-Guanidinoethylmercaptosuccinic acidGEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia.
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PrCP-7414
0 ImagesCat. No.: HY-177760CAS No.: 1252037-41-4PrCP-7414 is a prolyl carboxypeptidase (PRCP) inhibitor. PrCP-7414 blocks PRCP-mediated activation of the IGF1R/HER3 signaling pathway and subsequent AKT activation. PrCP-7414 exhibits pro-apoptotic, anti-tumor and synergistic cytotoxic activities, and inhibits the proliferation and survival of triple-negative breast cancer cells. PrCP-7414 can be used for the research of breast cancer.
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Z-Phe-Leu-OH
0 ImagesSynonyms: NSC 334018Z-Phe-Leu-OH (NSC 334018) is a dipeptide acid. Z-Phe-Leu-OH undergoes hydrolysis by carboxypeptidase Y to release L-leucine. Z-Phe-Leu-OH acts as a substrate to assay carboxypeptidase Y peptidase activity.
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Sortin1
0 ImagesSortin1 is a vacuolar protein sorting inhibitor that targets carboxypeptidase Y (CPY). Sortin1 is a soluble and membrane vacuolar marker molecule in plants and yeast.
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