GCPII-IN-1 TFA
Based on 1 Customer Validation
GCPII-IN-1 (Compound 2) TFA is a GCPII (also known as PSMA) inhibitor with a Ki of 44.3 nM. GCPII-IN-1 TFA can be used in the research of prostate cancer.
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 1269794-89-9
- Formula: C14H22F3N3O9
- Molecular Weight:433.33
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-Prostate Cancer Compound Library
HY-L124
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Protease Inhibitor Library
HY-L147
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Multi-Target Compound Library
HY-L176
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MCE Bioactive Compound Library
HY-L001V
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Amino Acid Metabolism Compound Library
HY-L189
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
GCPII-IN-1 (compound KUE) TFA serves as a PSMA targeting vector to be conjugated with the zwitterionic metal chelators to generate probes for prostate cancer imaging applications[2].
GCPII-IN-1 TFA can be radiolabeled with F-18 to be a PET agent for prostate cancer imaging[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1269794-89-9
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Appearance Solid
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Molecular Weight 433.33
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Formula C14H22F3N3O9
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Color White to off-white
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SMILES
OC(C(F)(F)F)=O.NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 160 mg/mL (369.23 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (57.69 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Jan Tykvart, et al. Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg Med Chem. 2014 Aug 1;22(15):4099-108. [Content Brief]
[2]. John V. Frangioni, et al. Zwitterionic metal chelators. US20250082792A1. 2025-10-14.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.3077 mL | 11.5386 mL | 23.0771 mL | 57.6928 mL |
| 5 mM | 0.4615 mL | 2.3077 mL | 4.6154 mL | 11.5386 mL | |
| 10 mM | 0.2308 mL | 1.1539 mL | 2.3077 mL | 5.7693 mL | |
| 15 mM | 0.1538 mL | 0.7692 mL | 1.5385 mL | 3.8462 mL | |
| 20 mM | 0.1154 mL | 0.5769 mL | 1.1539 mL | 2.8846 mL | |
| 25 mM | 0.0923 mL | 0.4615 mL | 0.9231 mL | 2.3077 mL | |
| 30 mM | 0.0769 mL | 0.3846 mL | 0.7692 mL | 1.9231 mL | |
| 40 mM | 0.0577 mL | 0.2885 mL | 0.5769 mL | 1.4423 mL | |
| 50 mM | 0.0462 mL | 0.2308 mL | 0.4615 mL | 1.1539 mL | |
| 60 mM | 0.0385 mL | 0.1923 mL | 0.3846 mL | 0.9615 mL | |
| 80 mM | 0.0288 mL | 0.1442 mL | 0.2885 mL | 0.7212 mL | |
| 100 mM | 0.0231 mL | 0.1154 mL | 0.2308 mL | 0.5769 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
GCPII-IN-1 TFA Related Classifications
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