Signaling Pathway

Aminopeptidase

Aminopeptidase

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Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein (N-terminus) or peptide substrates. They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc Metalloenzymes. Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. CDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding. One important aminopeptidase is a zinc-dependent enzyme produced and secreted by glands of the small intestine. It helps the enzymatic digestion of proteins. Additional digestive enzymes produced by these glands include dipeptidases, maltase, sucrase, lactase, and enterokinase.

Aminopeptidase Inhibitors & Modulators (4)

Product Name Catalog No. Brief Description
Bestatin

HY-B0134

Bestatin (Ubenimex) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.

Bestatin hydrochloride

HY-B0134A

Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.

Bestatin trifluoroacetate

HY-B0134B

Bestatin (Ubenimex) trifluoroacetate is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.

DG051

HY-10825

DG051 is potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC50=47 nM.