1. Cell Cycle/DNA Damage
    Epigenetics
    Anti-infection
  2. HDAC
    DNA Methyltransferase
    DNA/RNA Synthesis
    Bacterial
  3. Psammaplin A

Psammaplin A 

Cat. No.: HY-N2150
Handling Instructions

Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity.

For research use only. We do not sell to patients.

Psammaplin A Chemical Structure

Psammaplin A Chemical Structure

CAS No. : 110659-91-1

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Description

Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].

IC50 & Target

IC50: 0.9 nM (DAC1)[1]

Molecular Weight

664.39

Formula

C₂₂H₂₄Br₂N₄O₆S₂

CAS No.

110659-91-1

SMILES

O=C(NCCSSCCNC(/C(CC1=CC(Br)=C(O)C=C1)=N/O)=O)/C(CC2=CC(Br)=C(O)C=C2)=N/O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Psammaplin AHDACDNA MethyltransferaseDNA/RNA SynthesisBacterialHistone deacetylasesDNMTsDNA MTasesHDAC1antitumormarinemetabolitepigeneticoximecytotoxicityantimicrobiaDNAgyraseInhibitorinhibitorinhibit

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