2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aminopeptidase
  5. CD13 Isoform

CD13

CD13/aminopeptidase N (APN) is a widely expressed transmembrane ectoenzyme in endothelial, epithelial, fibroblast, and leukocyte populations[1]. Mechanistically, CD13 regulates cytokine activity by N-terminal cleavage, participates in MHC class II peptide trimming, and also mediates signal transduction, receptor recycling, FcγR-mediated phagocytosis, and cytokine-receptor functions independent of enzymatic activity[2]. In inflammatory models, IFN-γ regulated CD13/APN mRNA, membrane CD13, and enzyme activity in HL-60 myelo-monocytic cells, supporting cytokine-dependent control during inflammation[3]. In cancer research, CD13 is a Zn2+-dependent membrane ectopeptidase associated with growth of different human cancers and evaluated as a target for inhibitors and APN-targeted carrier constructs[4]. Compared with related aminopeptidase isoforms, CD13/APN is specifically framed as a \"moonlighting\" enzyme because its receptor and signaling roles do not always depend on catalytic activity[5]. This distinction is experimentally important because lung cancer cell migration increased even with catalytically inactive CD13, whereas anti-CD13 antibodies reduced migration and invasion[6]. For applications, natural and synthetic APN inhibitors help analyze peptide-response modulation, immune functions, proliferation, secretion, invasion, and angiogenesis[1].

CD13 Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-B0134
    Bestatin
    		Inhibitor 99.98%
    Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects.
  • HY-B0134A
    Bestatin hydrochloride
    		99.94%
    Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.
  • HY-P1043A
    NGR peptide Trifluoroacetate
    		98.91%
    NGR peptide Trifluoroacetatecontaining the Asn-Gly-Arg (NGR) motif. NGR peptide Trifluoroacetate binds to APN/CD13. NGR peptide Trifluoroacetate is directly conjugated to imaging agents that can be used for tumor imaging.
  • HY-B0134AS
    Bestatin-d7 hydrochloride
    		Inhibitor
    Bestatin-d7 (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.
  • HY-P4205
    Aminopeptidase N Ligand (CD13) NGR peptide
    		Inhibitor 99.54%
    Aminopeptidase N Ligand (CD13) NGR peptide is a polypeptide targeting CD13 and can be used as a carrier to mediate intracellular transmission. Aminopeptidase N Ligand (CD13) NGR peptide is often used in cancer research.
  • HY-P1043
    NGR peptide
    		99.73%
    NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging.
  • HY-173145
    CD13-IN-1
    		Inhibitor
    CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 of 1.71 μM. CD13-IN-1 can inhibit the proliferation of multiple tumor cells and has anti-tumor activity.
  • HY-B0134B
    Bestatin trifluoroacetate
    		Inhibitor
    Bestatin trifluoroacetate is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.