1. GPCR/G Protein
  2. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Related Products (86):

Cat. No. Product Name Effect Purity
  • HY-101952
    Prostaglandin E2 Activator 98.01%
    Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
  • HY-B0131
    Prostaglandin E1 Agonist >98.0%
    Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor.
  • HY-103088
    E7046 Antagonist 99.60%
    E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities.
  • HY-50901
    ONO-AE3-208 Antagonist 98.08%
    ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.
  • HY-18966
    PF-04418948 Antagonist 99.60%
    PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.
  • HY-114141
    BI-671800 Antagonist 99.06%
    BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has potential for the treatment of poorly controlled asthma.
  • HY-108415
    Cloprostenol sodium salt Agonist 99.81%
    Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist.
  • HY-112604
    MK-8318 Antagonist
    MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.
  • HY-A0096
    Iloprost Agonist 99.06%
    Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2.
  • HY-16768
    Fevipiprant Antagonist 98.73%
    Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.
  • HY-16781
    Grapiprant Antagonist 99.68%
    Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
  • HY-B0610
    Misoprostol Agonist >99.0%
    Misoprostol(SC29333) is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion.
  • HY-14899
    Taprenepag Agonist 99.26%
    CP-544326 is a potent and selective prostaglandin E2 receptor agonist with an EC50 of 2.8 nM.
  • HY-79593
    MRE-269 Agonist 99.91%
    MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
  • HY-10418
    AH 6809 Antagonist 99.47%
    AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors.
  • HY-12956A
    Dinoprost tromethamine salt Agonist >98.0%
    Dinoprost(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
  • HY-16963
    GW627368 Antagonist 99.88%
    GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).
  • HY-16978
    TG6-10-1 Antagonist 99.28%
    TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.
  • HY-15950
    AZD1981 Antagonist 99.26%
    AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4).
  • HY-50175
    Laropiprant Antagonist 99.21%
    Laropiprant is a potent, selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.
Isoform Specific Products

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