1. GPCR/G Protein
  2. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Related Products (76):

Cat. No. Product Name Effect Purity
  • HY-101952
    Prostaglandin E2 Activator 98.01%
    Prostaglandin E2 is a vasodilator isolated from prostate gland secretion, working by binding and activating the prostaglandin E2 receptor.
  • HY-B0131
    Prostaglandin E1 Agonist >98.0%
    Prostaglandin E1 (Alprostadil) is a prostaglandin, which is used in the treatment of erectile dysfunction and has vasodilatory properties.
  • HY-103088
    E7046 Antagonist 99.60%
    E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities.
  • HY-50901
    ONO-AE3-208 Antagonist >98.0%
    ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.
  • HY-18966
    PF-04418948 Antagonist 99.60%
    PF-04418948 is a novel, potent and selective prostaglandin EP2 receptor antagonist with IC50 of 16 nM, displays >2000-fold functional selectivity for the human EP2 receptor over antagonist activity against the human EP1, EP3, EP4, DP1 and CRTH2 receptors.
  • HY-16751
    Ralinepag Agonist 98.87%
    Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
  • HY-N2391
    p-Hydroxycinnamic acid 99.85%
    p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
  • HY-108912
    RO1138452 Antagonist 98.21%
    RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06.
  • HY-16768
    Fevipiprant Antagonist 98.73%
    Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.
  • HY-16781
    Grapiprant Antagonist 99.68%
    Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2).
  • HY-A0096
    Iloprost Agonist 99.83%
    Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2.
  • HY-B0577
    Latanoprost
    Latanoprost is an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
  • HY-16978
    TG6-10-1 Antagonist 99.28%
    TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.
  • HY-14899
    Taprenepag Agonist 98.62%
    CP-544326 is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM) .
  • HY-B0745
    Ramatroban Antagonist 99.16%
    Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.
  • HY-16963
    GW627368 Antagonist 99.88%
    GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).
  • HY-14870
    NS-304 Agonist 99.93%
    NS-304 is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).
  • HY-50175
    Laropiprant Antagonist 99.21%
    Laropiprant is a potent, selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.
  • HY-12956A
    Dinoprost tromethamine salt Agonist >98.0%
    Dinoprost(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
  • HY-B0610
    Misoprostol Agonist >99.0%
    Misoprostol(SC29333) is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion.
Isoform Specific Products

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