1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. U-46619

U-46619 (Synonyms: 9,11-Methanoepoxy PGH2)

Cat. No.: HY-108566
Handling Instructions

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist.

For research use only. We do not sell to patients.

U-46619 Chemical Structure

U-46619 Chemical Structure

CAS No. : 56985-40-1

Size Price Stock Quantity
1 mg (28.5 mM * 100  μL in Methyl acetate) USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg (28.5 mM * 500  μL in Methyl acetate) USD 990 In-stock
Estimated Time of Arrival: December 31

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist[1].

IC50 & Target

TXA2[1]

In Vitro

U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1].
U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1].
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1].
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].

In Vivo

U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3].

Animal Model: 12-15 weeks-old male and female SHR[2]
Dosage: 5 μg/kg
Administration: Intravenous injection
Result: Induceed a significant increase of MABP after 1 min in male SHR.
Molecular Weight

350.49

Formula

C₂₁H₃₄O₄

CAS No.

56985-40-1

SMILES

O=C(O)CCC/C=C\C[[email protected]]1[[email protected]@]2([H])CO[[email protected]@](C2)([H])[[email protected]@H]1/C=C/[[email protected]@H](O)CCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

U-466199,11-Methanoepoxy PGH2U46619U 46619Prostaglandin ReceptorTXA2plateletsshapechangeaggregationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
U-46619
Cat. No.:
HY-108566
Quantity:
MCE Japan Authorized Agent: