1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. U-46619

U-46619 (Synonyms: 9,11-Methanoepoxy PGH2)

Cat. No.: HY-108566 Purity: >99.0%
Handling Instructions

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist.

For research use only. We do not sell to patients.

U-46619 Chemical Structure

U-46619 Chemical Structure

CAS No. : 56985-40-1

Size Price Stock Quantity
1 mg (28.5 mM * 100 μL in Methyl acetate) USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg (28.5 mM * 500 μL in Methyl acetate) USD 990 In-stock
Estimated Time of Arrival: December 31

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review


U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist[1].

IC50 & Target


In Vitro

U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1].
U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1].
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1].
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].

In Vivo

U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3].

Animal Model: 12-15 weeks-old male and female SHR[2]
Dosage: 5 μg/kg
Administration: Intravenous injection
Result: Induceed a significant increase of MABP after 1 min in male SHR.
Molecular Weight







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Room temperature in continental US; may vary elsewhere.

Pure form -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month

Purity: >99.0%

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U-466199,11-Methanoepoxy PGH2U46619U 46619Prostaglandin ReceptorTXA2plateletsshapechangeaggregationInhibitorinhibitorinhibit

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