2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor
  5. DP Isoform

DP

 

DP Related Products (32):

Cat. No. Product Name Effect Purity
  • HY-B0195
    Tranilast
    		Inhibitor 99.57%
    Tranilast (MK-341) acts as an anti-atopic agent.
  • HY-50175
    Laropiprant
    		Antagonist 99.73%
    Laropiprant is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.
  • HY-10418
    AH 6809
    		Antagonist 99.47%
    AH 6809 is an antagonist of EP and DP receptor, with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively.
  • HY-100441
    Treprostinil
    		Inhibitor 99.98%
    Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
  • HY-16768
    Fevipiprant
    		Antagonist 99.51%
    Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an Kd value of 1.14 nM.
  • HY-113366
    Prostaglandin J2
    		Agonist
    Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively.
  • HY-16763
    Asapiprant
    		Antagonist 99.58%
    Asapiprant is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM.
  • HY-101987
    BW 245C
    		Agonist 99.14%
    BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.
  • HY-111271
    L 888607
    		Agonist 99.95%
    L 888607 is a potent, selective, stable and orally active CRTH2 agonist.
  • HY-13448
    Nedocromil
    		Inhibitor 98.02%
    Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
  • HY-16504
    Treprostinil sodium
    		Agonist ≥98.0%
    Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
  • HY-15950
    AZD1981
    		Antagonist 99.82%
    AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4).
  • HY-B0745
    Ramatroban
    		Antagonist 99.10%
    Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.
  • HY-16635
    Setipiprant
    		Antagonist 98.70%
    Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist.
  • HY-15853
    MK-7246
    		Antagonist 98.95%
    MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM.
  • HY-16751
    Ralinepag
    		Agonist 99.70%
    Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
  • HY-114141
    BI-671800
    		Antagonist 99.23%
    BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively.
  • HY-111271A
    L 888607 Racemate
    		Antagonist 99.83%
    L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.
  • HY-13706
    CAY10471 Racemate
    		Antagonist 99.00%
    CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM).
  • HY-16344
    Nedocromil sodium
    		Inhibitor
    Nedocromil sodium suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).