1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Treprostinil palmitil

Treprostinil palmitil (Synonyms: INS-1009)

Cat. No.: HY-109163
Handling Instructions

Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors.

For research use only. We do not sell to patients.

Treprostinil palmitil Chemical Structure

Treprostinil palmitil Chemical Structure

CAS No. : 1706528-83-7

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Description

Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors[1][2].

Molecular Weight

614.94

Formula

C₃₉H₆₆O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (325.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6262 mL 8.1309 mL 16.2617 mL
5 mM 0.3252 mL 1.6262 mL 3.2523 mL
10 mM 0.1626 mL 0.8131 mL 1.6262 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 9.09 mg/mL (14.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (8.13 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (8.13 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Treprostinil palmitil
Cat. No.:
HY-109163
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