Treprostinil palmitil (Standard)
Treprostinil palmitil (Standard) is the analytical standard of Treprostinil palmitil (HY-109163). This product is intended for research and analytical applications. Treprostinil palmitil is a long-acting inhaled pulmonary vasodilator prodrug of Treprostinil (HY-100441), formulated in a lipid nanoparticle (LNP). Treprostinil palmitil can inhibit pulmonary vascular remodeling induced by Su/Hx challenge in rats. Treprostinil palmitil can induce cough. Treprostinil palmitil demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Treprostinil palmitil can be studied in research for pulmonary arterial hypertension and interstitial lung disease.
For research use only. We do not sell to patients.
- CAS No.: 1706528-83-7
- Formula: C39H66O5
- Molecular Weight:614.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 1706528-83-7
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Molecular Weight 614.94
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Formula C39H66O5
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SMILES
CCCCC[C@H](O)CC[C@@H]1[C@]2([H])[C@@](C[C@H]1O)([H])CC3=C(OCC(OCCCCCCCCCCCCCCCC)=O)C=CC=C3C2
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Synonyms
INS-1009 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chapman RW, Corboz MR, Malinin VS, Plaunt AJ, Konicek DM, Li Z, Perkins WR. An overview of the biology of a long-acting inhaled treprostinil prodrug. Pulm Pharmacol Ther. 2020 Dec;65:102002. [Content Brief]
[2]. Corboz, M. R., et al., (2022). Assessment of Inhaled Treprostinil Palmitil, Inhaled and Intravenous Treprostinil, and Oral Selexipag in a Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension. The Journal of pharmacology and experimental therapeutics, 383(1), 103–116. [Content Brief]
[3]. Chapman, R. W., et al., (2021). Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil. ERJ open research, 7(1), 00592-2020. [Content Brief]
[4]. Plaunt, A. J., et al., (2021). Development and Characterization of Treprostinil Palmitil Inhalation Aerosol for the Investigational Treatment of Pulmonary Arterial Hypertension. International journal of molecular sciences, 22(2), 548. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Treprostinil palmitil (Standard) Related Classifications
HY-109163R Related Classifications
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