F-Fragments Library

Cat. No.: HY-L152: Library Contents: XLSX PDF SDF

19F-NMR has proved to be a detection mode in fragment-based drug discovery (FBDD) for studies of protein structure and interactions. 19F shows high sensitivity for NMR detection, and the exquisite sensitivity of 19F chemical shifts and linewidths to ligand binding all make it a valuable approach in FBDD.F (Fluorine) -Fragments can be used for 19F-NMR detection after binding to target proteins, and can be used as an effective 19F-NMR tool for FBDD.

MCE designs a unique collection of 4973 F-fragments, all of which obey a heuristic rule called the “Rule of Three (RO3)”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This F-fragments library is an important source of lead-like drugs.

Size (Pre-dissolved Solution or Solid)	Price	Stock
30 μL/well Solution 10 mM Pre-dissolved Solution	Get quote	In-stock
50 μL/well Solution 10 mM Pre-dissolved Solution	Get quote	In-stock
100 μL/well Solution 10 mM Pre-dissolved Solution	Get quote	In-stock
2 × 100 μL/well Solution 10 mM Pre-dissolved Solution	Get quote	In-stock

Download Screening Library Catalog

Please contact us at

[email protected]

Publications Citing Use of MCE Compound Libraries

Description
Product Details
Documentation

Description
& Advantages

• A unique collection of 4973 fragment compounds for traditional lead identification via high-throughput screening (HTS).

• The compounds follow the Rule of Three.

• A useful tool for the fragment-based approach to drug discovery (FBDD).

• More detailed compound information with structure, Molecular Weight, cLogP, H-donor and H-acceptor number.

• NMR and HPLC validated ensure high purity.

• All compounds are in stock and continuously updated.

Parameter	Range	Average Value
Molecular Weight	≤300	[MW average]
cLogP	≤3.0	[cLogP average]
H-donors	≤3.0	[H-donors average]
H-acceptors	≤3.0	[H-acceptors average]

Product Details

Formulation:: A collection of 4973 fragment compounds supplied as pre-dissolved Solutions or Solid
Solution: 4973 compounds supplied in 10 mM solution.
Layout:: 96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:: 96- or 384-well Plate with Peelable Foil Seal
Storage:: In solvent: -80°C 2 years, -20°C 1 year; Powder: -20°C 3 years, 4°C 2 years
Shipping:: Blue ice

Documentation

XLSX PDF Library Handling Instructions (351 KB)

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Container *

Remarks