B7-H2/CD275
B7-H2, the ICOS ligand (ICOSLG), also carries the CD275 designation and was the fifth B7 family member to be described. It is a type I transmembrane protein with two Ig-like extracellular domains, expressed constitutively on B cells, monocytes and dendritic cells and inducible on endothelium. By binding its receptor ICOS (CD278) on activated T cells, it delivers costimulatory signals that support T helper cell differentiation, T follicular helper cell generation, IL-10 secretion and germinal center reactions. The ICOS-ICOSLG axis is essential for humoral immunity, and its blockade or agonism is under investigation in transplant rejection, autoimmunity and cancer immunotherapy.
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B7-H2/CD275 Recombinant Proteins (11)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
