1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

5-HT Receptor

5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, including glutamate, GABA, dopamine, epinephrine / norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin, cortisol, corticotropin, and substance P, among others. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

5-HT Receptor Related Products (153):

Cat. No. Product Name Effect Purity
  • HY-A0021
    Palonosetron Hydrochloride Antagonist
    Palonosetron Hcl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
  • HY-A0008
    B-HT 920 Antagonist
    B-HT 920(Talipexole 2Hcl) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.
  • HY-70050C
    Alosetron Hydrochloride Antagonist
    Alosetron Hcl is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
  • HY-13105
    WAY-100635 maleate salt Antagonist
    WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT.
  • HY-11018
    Risperidone Inhibitor
    Risperidone(R 64 766) is a serotonin 5-HT2 receptor blocker(Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist(Ki= 1.4 nM).
  • HY-10562
    Ketanserin Antagonist
    Ketanserin is a selective 5-HT receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
  • HY-10559
    Nelotanserin Inhibitor
    Nelotanserin is a potent selective 5-HT2A inverse agonist, nelotanserin has low nanomolar potency on the 5-HT2A receptor with at least 30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors.
  • HY-14149
    Cisapride Agonist
    Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent human ether-à-go-go-related gene (hERG) potassium channel inhibitor
  • HY-14261
    Vilazodone Hydrochloride Inhibitor
    Vilazodone Hcl (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
  • HY-90003A
    Tianeptine sodium salt Agonist
    Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo.
  • HY-B0071A
    Granisetron Hydrochloride Antagonist
    Granisetron Hcl(BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
  • HY-B0020
    Tropisetron Hydrochloride Antagonist
    Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
  • HY-11100
    Asenapine maleate Inhibitor
    Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 angonist with Ki values of 0.03-4.0 nM, 1.3nM,respectively, and an antipsychotic.
  • HY-90003
    Tianeptine Agonist
    Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo.
  • HY-10564
    Sarpogrelate hydrochloride Antagonist
    Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
  • HY-10121
    Asenapine Antagonist
    Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
  • HY-14336A
    SB 271046 Hydrochloride Antagonist
    SB271046 Hcl is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
  • HY-13221
    BRL 54443 Agonist
    BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively); displays > 30-fold selectivity over other 5-HT and dopamine receptors.
  • HY-10349
    WAY-100635 Antagonist
    WAY-100635 is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT.
  • HY-70050A
    Alosetron Antagonist
    Alosetron is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.