Signaling Pathway

5-HT Receptor

5-HT Receptor

Related Products

PDF File 0.85MB

5-HT receptor (serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, including glutamate, GABA, dopamine, epinephrine / norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin, cortisol, corticotropin, and substance P, among others. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7.

5-HT Receptor Inhibitors & Modulators (152)

Product Name Catalog No. Brief Description
Adoprazine

HY-14782

Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.

Agomelatine

HY-17038

Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).

Agomelatine hydrochloride

HY-17038A

Agomelatine hydrochloride is a  antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.

Agomelatine L(+)-Tartaric acid

HY-17038B

Agomelatine (L(+)-Tartaric acid) is a  antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.

Almotriptan

HY-B0383A

Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine.

Almotriptan malate

HY-B0383

Almotriptan Malate is a 5-HT1B/1D-receptor agonist used to treat migraine.

Alosetron

HY-70050A

Alosetron is s Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.

Alosetron (Z)-2-butenedioate

HY-70050B

Alosetron is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.

Alosetron D3 Hydrochloride

HY-70050CS

Alosetron D3 Hcl is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

Alosetron Hydrochloride

HY-70050C

Alosetron Hcl is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.

Alosetron Hydrochloride(1:X)

HY-70050

Alosetron is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.

Alprenolol

HY-B1517

Alprenolol is a non-selective beta blocker as well as 5-HT1A receptor antagonist.

Alprenolol hydrochloride

HY-B1517A

Alprenolol (hydrochloride) is a non-selective beta blocker as well as 5-HT1A receptor antagonist.

Alverine citrate

HY-B0500

Alverine Citrate(NSC35459) is a drug used for functional gastrointestinal disorders.

Amitifadine hydrochloride

HY-18332A

Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

Aripiprazole

HY-14546

Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

Aripiprazole D8

HY-14546S

Aripiprazole D8 is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

Asenapine

HY-10121

Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

Asenapine hydrochloride

HY-16567

Asenapine hydrochloride inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

Asenapine maleate

HY-11100

Asenapine maleate(Org 5222 maleate) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.