6190-39-2
6190-39-2
Chemical Structure
Dihydroergotamine mesylate
- CAS No.: 6190-39-2
- Formula:C34H41N5O8S
- Molecular Weight:679.78
IUPAC Name: (6aR,9R,10aR)-N-((2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate
InChIKey: ADYPXRFPBQGGAH-UMYZUSPBSA-N
SMILES: O[C@@]([C@@](CCC1)([H])N1C2=O)(O[C@](NC([C@@H](CN(C)[C@]3([H])C4)C[C@]3([H])C5=C6C4=CNC6=CC=C5)=O)(C)C7=O)N7[C@H]2CC8=CC=CC=C8.CS(=O)(O)=O
Biological Activity: Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid that can be used for the research of migraines[1][2][3].
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Dihydroergotamine mesylate | 99.94% | Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid that can be used for the research of migraines. | ||||||||||||||||||||
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Dihydroergotamine mesylate (Standard) | ≥98% | Dihydroergotamine (mesylate) (Standard) is the analytical standard of Dihydroergotamine (mesylate). This product is intended for research and analytical applications. Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid that can be used for the research of migraines. | ||||||||||||||||||||
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References
- [1]. Colman, I., et al., Parenteral dihydroergotamine for acute migraine headache: a systematic review of the literature. Ann Emerg Med, 2005. 45(4): p. 393-401. [Content Brief]
- [2]. Saper, J.R., et al., DHE in the pharmacotherapy of migraine: potential for a larger role. Headache, 2006. 46 Suppl 4: p. S212-20. [Content Brief]
- [3]. Schaerlinger, B., et al., Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Br J Pharmacol, 2003. 140(2): p. 277-84. [Content Brief]
