2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor 5-HT Receptor
  4. Dihydroergotamine

Dihydroergotamine (DFN-19) is a BBB-permeable and semisynthetic, hydrogenated ergot alkaloid. Dihydroergotamine can cause vasoconstriction by stimulating alpha-adrenergic and 5-HT2A receptors. Dihydroergotamine can be used in the research of migraine.

For research use only. We do not sell to patients.

CAS No. : 511-12-6

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Dihydroergotamine Related Antibodies

Top Publications Citing Use of Products

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654.  [Abstract]

    THLE3, Hep3B and HepG2 cells were treated with DMSO or DHE (20, 40, 60 μM) as indicated concentration for 48 h under hypoxia, followed by crystal violet staining assay.

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654.  [Abstract]

    His-PADI4 proteins were incubated with DMSO or DHE (10, 60 μM) under the indicated temperature before western blotting analysis.

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654.  [Abstract]

    Cell lysates of Hep3B-Flag-PADI4 cells were incubated with DMSO, 50 μM DHE, or 50 μM BBCA at 37 °C for 20 min before western blotting analysis. The samples were derived from the same experiment, but different gels for pan-Cit, another for Flag, Actin were processed in parallel.

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654.  [Abstract]

    Pull-down of His-PADI4 by GST-HIF-1α in the presence of DMSO or DHE as indicated concentration. g An in vitro citrullination assay of GST-HIF-1α was performed in the presence of DMSO or DHE as indicated concentration. The samples were derived from the same experiment, but different gels for R698Cit, His, another for GST were processed in parallel.

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654.  [Abstract]

    Total mRNA in Hep3B cells treated with DMSO or 20 μM, or 40 μM DHE under hypoxic conditions for 24 h were subjected to RNA-sequencing, followed by GO biological processes analysis.

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654.  [Abstract]

    Total mRNA in Hep3B cells treated with DMSO or 20 μM, or 40 μM DHE under hypoxic conditions for 24 h were subjected to RNA-sequencing, followed by GSEA analysis.

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654.  [Abstract]

    Parental Hep3B cells were injected subcutaneously into the flanks of BALB/c nude mice (n = 6 per group). After 12 days, the mice were treated with DMSO or DHE (25 mg/kg or 75 mg/kg) by i.g every 2 days. Tumour volume was determined starting on Day 14 and photographs show xenografts at the end of the experiment.

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654.  [Abstract]

    Parental Hep3B cells were injected subcutaneously into the flanks of BALB/c nude mice (n = 6 per group). After 12 days, the mice were treated with DMSO or DHE (25 mg/kg or 75 mg/kg) by i.g every 2 days. Tumour weight was measured.

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    α adrenergic receptor β adrenergic receptor

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    5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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    Description

    Dihydroergotamine (DFN-19) is a BBB-permeable and semisynthetic, hydrogenated ergot alkaloid. Dihydroergotamine can cause vasoconstriction by stimulating alpha-adrenergic and 5-HT2A receptors. Dihydroergotamine can be used in the research of migraine[1].

    IC50 & Target[1]

    α adrenergic receptor

     

    5-HT2A Receptor

     

    Clinical Trial
    Molecular Weight

    583.68

    Formula

    C33H37N5O5
    CAS No.
    SMILES

    O[C@@]([C@@](CCC1)([H])N1C2=O)(O[C@](NC([C@@H](CN(C)[C@]3([H])C4)C[C@]3([H])C5=C6C4=CNC6=CC=C5)=O)(C)C7=O)N7[C@H]2CC8=CC=CC=C8
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Dihydroergotamine Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dihydroergotamine511-12-6DFN-19DFN19DFN 19Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptorergot alkaloidmigraineInhibitorinhibitorinhibit

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