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Dihydroergotamine

(Synonyms: DFN-19)
5 Cited Publications
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Based on 5 publication(s) in Google Scholar

Dihydroergotamine (DFN-19) is a BBB-permeable and semisynthetic, hydrogenated ergot alkaloid. Dihydroergotamine can cause vasoconstriction by stimulating alpha-adrenergic and 5-HT2A receptors. Dihydroergotamine can be used in the research of migraine.

For research use only. We do not sell to patients.

  • CAS No.: 511-12-6
  • Formula: C33H37N5O5
  • Molecular Weight:583.68
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Dihydroergotamine Chemical Structure
    Dihydroergotamine Chemical Structure
  • Experimental Validation Results for Dihydroergotamine
  • Experimental Validation Results for Dihydroergotamine
  • Experimental Validation Results for Dihydroergotamine
  • Experimental Validation Results for Dihydroergotamine
  • Experimental Validation Results for Dihydroergotamine
  • Experimental Validation Results for Dihydroergotamine
  • Experimental Validation Results for Dihydroergotamine
  • Experimental Validation Results for Dihydroergotamine
CAS No.: 511-12-6
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Cell Imaging/StainingWBIPBio/Physico-chemical AssayIn Vivo Efficacy Study
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  • Bio/Physico-chemical Assay
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All Adrenergic Receptor Isoforms

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  • Dihydroergotamine Chemical Structure
    Dihydroergotamine Chemical Structure
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  • 1/16

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654. [Abstract]

    Customer Validation
     THLE3, Hep3B and HepG2 cells were treated with DMSO or DHE (20, 40, 60 μM) as indicated concentration for 48 h under hypoxia, followed by crystal violet staining assay.

  • 1/16

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654. [Abstract]

    Customer Validation
     His-PADI4 proteins were incubated with DMSO or DHE (10, 60 μM) under the indicated temperature before western blotting analysis.

  • 1/16

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654. [Abstract]

    Customer Validation
     Cell lysates of Hep3B-Flag-PADI4 cells were incubated with DMSO, 50 μM DHE, or 50 μM BBCA at 37 °C for 20 min before western blotting analysis. The samples were derived from the same experiment, but different gels for pan-Cit, another for Flag, Actin were processed in parallel.

  • 1/16

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654. [Abstract]

    Customer Validation
     Pull-down of His-PADI4 by GST-HIF-1α in the presence of DMSO or DHE as indicated concentration. g An in vitro citrullination assay of GST-HIF-1α was performed in the presence of DMSO or DHE as indicated concentration. The samples were derived from the same experiment, but different gels for R698Cit, His, another for GST were processed in parallel.

  • 1/16

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654. [Abstract]

    Customer Validation
     Total mRNA in Hep3B cells treated with DMSO or 20 μM, or 40 μM DHE under hypoxic conditions for 24 h were subjected to RNA-sequencing, followed by GO biological processes analysis.

  • 1/16

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654. [Abstract]

    Customer Validation
     Total mRNA in Hep3B cells treated with DMSO or 20 μM, or 40 μM DHE under hypoxic conditions for 24 h were subjected to RNA-sequencing, followed by GSEA analysis.

  • 1/16

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654. [Abstract]

    Customer Validation
     Parental Hep3B cells were injected subcutaneously into the flanks of BALB/c nude mice (n = 6 per group). After 12 days, the mice were treated with DMSO or DHE (25 mg/kg or 75 mg/kg) by i.g every 2 days. Tumour volume was determined starting on Day 14 and photographs show xenografts at the end of the experiment.

  • 1/16

    Dihydroergotamine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 3;15(1):7654. [Abstract]

    Customer Validation
     Parental Hep3B cells were injected subcutaneously into the flanks of BALB/c nude mice (n = 6 per group). After 12 days, the mice were treated with DMSO or DHE (25 mg/kg or 75 mg/kg) by i.g every 2 days. Tumour weight was measured.

  • Dihydroergotamine