5-HT₇ Receptor Inhibitors

5-HT₁ Receptor

5-HT₂ Receptor

5-HT₃ Receptor

5-HT₅ Receptor

5-HT₆ Receptor

5-HT₇ Receptor

5-HT Receptor

5-HT₄ Receptor

5-HT₇ Receptor Specific Inhibitors, Agonists, Antagonists & Modulators

Product Name	5-HT₇ Receptor	5-HT₁ Receptor	5-HT₂ Receptor	5-HT₃ Receptor	5-HT₅ Receptor	5-HT₆ Receptor	5-HT₇ Receptor Selectivity	Purity
SB-269970 hydrochloride	5-HT₇ Receptor, pKi: 8.3						Selective Antagonist	98.77%
Lurasidone	5-HT₇ Receptor, IC₅₀: 0.495 nM	5-HT_1A Receptor, IC₅₀: 6.75 nM					Selective Modulator	99.49%
Asenapine maleate	5-HT₇ Receptor, Ki: 0.13 nM		5-HT_2A Receptor, Ki: 0.06 nM 5-HT_2C Receptor, Ki: 0.03 nM				Selective Antagonist	99.95%
Lurasidone Hydrochloride	5-HT₇ Receptor, IC₅₀: 0.495 nM	5-HT_1A Receptor, IC₅₀: 6.75 nM					Selective Modulator	99.87%
Asenapine hydrochloride	5-HT₇ Receptor, Ki: 0.13 nM		5-HT_2A Receptor, Ki: 0.06 nM 5-HT_2C Receptor, Ki: 0.03 nM				Selective Antagonist	99.39%
SB 258719	5-HT₇ Receptor, pKi: 7.5						Selective Antagonist	99.16%
JNJ-18038683	Rat 5-HT₇ Receptor, pKi: 8.19 (in HEK293 cells ) Human 5-HT₇ Receptor , pKi: 8.20 (in HEK293 cells )						Selective Antagonist	99.21%
SB-269970	Human 5-HT₇ Receptor , pKi: 8.3						Selective Antagonist
AS19	Human 5-HT₇ Receptor , IC₅₀: 0.83 nM Human 5-HT₇ Receptor , Ki: 0.6 nM	5-HT_1A Receptor, Ki: 89.7 nM 5-HT_1B Receptor, Ki: 490 nM 5-HT_1D Receptor, Ki: 6.6 nM			5-HT₅ Receptor, Ki: 98.5 nM		Selective Agonist	>99.0%
SEP-363856 hydrochloride	5-HT₇ Receptor, EC₅₀: 6.7 μM	5-HT_1A Receptor, EC₅₀: 2.3 μM 5-HT_1B Receptor, EC₅₀: 15.6 μM 5-HT_1D Receptor, EC₅₀: 0.262 μM	5-HT_2A Receptor, EC₅₀: >10 μM 5-HT_2C Receptor, EC₅₀: 30 μM				Pan Agonist	99.78%
Methiothepin mesylate	5-HT₇ Receptor, pKd: 8.99	5-HT_1A Receptor, pKd: 7.10 5-HT_1B Receptor, pKd: 7.28 5-HT_1C Receptor, pKd: 7.56 5-HT_1D Receptor, pKd: 6.99	5-HT_2A Receptor, pKi: 8.50 5-HT_2B Receptor, pKi: 8.68 5-HT_2C Receptor, pKi: 8.35		5-HT_5A Receptor, pKd: 7.0 5-HT_5B Receptor, pKd: 7.8	5-HT₆ Receptor, pKd: 8.74	Pan Antagonist	99.32%
8-OH-DPAT	5-HT₇ Receptor, Ki: 466 nM	5-HT_1A Receptor, pIC₅₀: 8.19					Pan Agonist	>98.0%
Vortioxetine hydrobromide	5-HT₇ Receptor, Ki: 19 nM			5-HT_3A Receptor, Ki: 3.7 nM			Pan Inhibitor	99.94%
Rotigotine	5-HT₇ Receptor, Ki: 86 nM	5-HT_1A Receptor, Ki: 30 nM					Pan Agonist	99.98%
Vortioxetine	Human 5-HT₇ Receptor , Ki: 19 nM			5-HT_3A Receptor, Ki: 3.7 nM			Pan Inhibitor	98.81%
Nuciferine	5-HT₇ Receptor, IC₅₀: 150 nM	5-HT_1A Receptor, EC₅₀: 3.2 μM	5-HT_2C Receptor, IC₅₀: 131 nM 5-HT_2A Receptor, IC₅₀: 478 nM 5-HT_2B Receptor, IC₅₀: 1 μM			5-HT₆ Receptor, EC₅₀: 700 nM	Pan Modulator	99.66%
LP-211	5-HT₇ Receptor, Ki: 0.58 nM	5-HT_1A Receptor, Ki: 188 nM					Pan Agonist	99.66%
Asenapine	5-HT₇ Receptor, pKi: 9.9	5-HT_1A Receptor, pKi: 8.6 5-HT_1B Receptor, pKi: 8.4	5-HT_2A Receptor, pKi: 10.2 5-HT_2C Receptor, pKi: 10.5 5-HT_2B Receptor, pKi: 9.8		5-HT₅ Receptor, pKi: 8.8	5-HT₆ Receptor, pKi: 9.6	Pan Antagonist	98.81%
BRL 54443	5-HT₇ Receptor, Ki: >10,000 nM	5-HT_1E Receptor, Ki: 1.1 nM 5-HT_1F Receptor, Ki: 0.7 nM 5-HT_1A Receptor, Ki: 63 nM 5-HT_1B Receptor, Ki: 126 nM 5-HT_1D Receptor, Ki: 63 nM	5-HT_2A Receptor, Ki: 1259 nM 5-HT_2B Receptor, Ki: 100 nM 5-HT_2C Receptor, Ki: 316 nM			5-HT₆ Receptor, Ki: >10,000 nM	Pan Agonist	99.39%
Iloperidone	Rat 5-HT₇ Receptor, Ki: 21.6 nM	Rat 5-HT_1A, Ki: 168 nM	Rat 5-HT₂ Receptor, Ki: 3.1 nM Human 5-HT_2A Receptor, Ki: 5.6 nM Human 5-HT_2C Receptor, Ki: 42.8 nM			Rat 5-HT₆ Receptor, Ki: 42.7 μM	Pan Antagonist	99.64%
Rotigotine Hydrochloride	5-HT₇ Receptor, Ki: 86 nM	5-HT_1A Receptor, Ki: 30 nM					Pan Agonist	99.39%
SB 243213 dihydrochloride	Human 5-HT₇ Receptor , pKi: 5.64	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₆ Receptor, pKi: 6.5	Pan Antagonist	>99.0%
SB 243213 hydrochloride	Human 5-HT₇ Receptor , pKi: 5.64	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₆ Receptor, pKi: 6.5	Pan Antagonist
5-HT6/7 antagonist 1	5-HT₇ Receptor		5-HT_2A Receptor			5-HT₆ Receptor	Pan Antagonist
SB 243213	Human 5-HT₇ Receptor , pKi: 5.64	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₆ Receptor, pKi: 6.5	Pan Antagonist
5-Carboxamidotryptamine maleate	5-HT₇ Receptor	5-HT_1A Receptor 5-HT_1B Receptor 5-HT_1D Receptor			5-HT₅ Receptor		Pan Agonist
AP521	5-HT₇ Receptor, IC₅₀: 198 nM (in rat)	5-HT_1A Receptor, IC₅₀: 94 nM (in human) 5-HT_1A Receptor, IC₅₀: 135 nM (in rat) 5-HT_1B Receptor, IC₅₀: 254 nM (in rat) 5-HT_1B Receptor, IC₅₀: 5530 nM (in human) 5-HT_1D Receptor, IC₅₀: 418 nM (in human)			5-HT_5A Receptor, IC₅₀: 422 nM (in human)		Pan Agonist
5-HT7 agonist 1	5-HT₇ Receptor						Pan Agonist
Brilaroxazine	5-HT₇ Receptor, Ki: 2.7 nM	5-HT_1A Receptor, Ki: 1.5 nM	5-HT_2A Receptor, Ki: 2.5 nM 5-HT_2B Receptor, Ki: 0.19 nM				Pan Modulator
Iloperidone hydrochloride	Rat 5-HT₇ Receptor, Ki: 21.6 nM	Rat 5-HT_1A, Ki: 168 nM	Rat 5-HT₂ Receptor, Ki: 3.1 nM Human 5-HT_2A Receptor, Ki: 5.6 nM Human 5-HT_2C Receptor, Ki: 42.8 nM			Rat 5-HT₆ Receptor, Ki: 42.7 nM	Pan Antagonist

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5-HT7 Receptor Inhibitors

5-HT₇ Receptor Inhibitors