5-HT₇ Receptor Inhibitors

5-HT₁ Receptor

5-HT₂ Receptor

5-HT₃ Receptor

5-HT₅ Receptor

5-HT₆ Receptor

5-HT₇ Receptor

5-HT Receptor

5-HT₄ Receptor

5-HT₇ Receptor Specific Inhibitors, Agonists, Antagonists & Modulators

Product Name	5-HT₇ Receptor	5-HT₁ Receptor	5-HT₂ Receptor	5-HT₃ Receptor	5-HT₅ Receptor	5-HT₆ Receptor	5-HT₄ Receptor	5-HT₇ Receptor Selectivity	Purity
SB-269970 hydrochloride	5-HT₇ Receptor, pKi: 8.3							Selective Antagonist	98.77%
Lurasidone	5-HT₇ Receptor, IC₅₀: 0.495 nM	5-HT_1A Receptor, IC₅₀: 6.75 nM						Selective Modulator	99.49%
Asenapine maleate	5-HT₇ Receptor, Ki: 0.13 nM		5-HT_2A Receptor, Ki: 0.06 nM 5-HT_2C Receptor, Ki: 0.03 nM					Selective Antagonist	99.95%
Lurasidone Hydrochloride	5-HT₇ Receptor, IC₅₀: 0.495 nM	5-HT_1A Receptor, IC₅₀: 6.75 nM						Selective Modulator	99.87%
SB 258719	5-HT₇ Receptor, pKi: 7.5							Selective Antagonist	≥99.0%
Asenapine hydrochloride	5-HT₇ Receptor, Ki: 0.13 nM		5-HT_2A Receptor, Ki: 0.06 nM 5-HT_2C Receptor, Ki: 0.03 nM					Selective Antagonist	98.76%
JNJ-18038683	Rat 5-HT₇ Receptor, pKi: 8.19 (in HEK293 cells ) Human 5-HT₇ Receptor , pKi: 8.20 (in HEK293 cells )							Selective Antagonist	99.21%
SB-269970	Human 5-HT₇ Receptor , pKi: 8.3							Selective Antagonist
AS19	Human 5-HT₇ Receptor , IC₅₀: 0.83 nM Human 5-HT₇ Receptor , Ki: 0.6 nM	5-HT_1A Receptor, Ki: 89.7 nM 5-HT_1B Receptor, Ki: 490 nM 5-HT_1D Receptor, Ki: 6.6 nM			5-HT₅ Receptor, Ki: 98.5 nM			Selective Agonist	≥99.0%
8-OH-DPAT	5-HT₇ Receptor, Ki: 466 nM	5-HT_1A Receptor, pIC₅₀: 8.19						Pan Agonist	≥98.0%
Methiothepin mesylate	5-HT₇ Receptor, pKd: 8.99	5-HT_1A Receptor, pKd: 7.10 5-HT_1B Receptor, pKd: 7.28 5-HT_1C Receptor, pKd: 7.56 5-HT_1D Receptor, pKd: 6.99	5-HT_2A Receptor, pKi: 8.50 5-HT_2B Receptor, pKi: 8.68 5-HT_2C Receptor, pKi: 8.35		5-HT_5A Receptor, pKd: 7.0 5-HT_5B Receptor, pKd: 7.8	5-HT₆ Receptor, pKd: 8.74		Pan Antagonist	≥98.0%
Vortioxetine hydrobromide	5-HT₇ Receptor, Ki: 19 nM			5-HT_3A Receptor, Ki: 3.7 nM				Pan Inhibitor	99.94%
LP-211	5-HT₇ Receptor, Ki: 0.58 nM	5-HT_1A Receptor, Ki: 188 nM						Pan Agonist	99.61%
Vortioxetine	Human 5-HT₇ Receptor , Ki: 19 nM			5-HT_3A Receptor, Ki: 3.7 nM				Pan Inhibitor	99.52%
Iloperidone	Rat 5-HT₇ Receptor, Ki: 21.6 nM	Rat 5-HT_1A Receptor, Ki: 168 nM	Rat 5-HT₂ Receptor, Ki: 3.1 nM Human 5-HT_2A Receptor, Ki: 5.6 nM Human 5-HT_2C Receptor, Ki: 42.8 nM			Rat 5-HT₆ Receptor, Ki: 42.7 μM		Pan Antagonist	99.64%
Rotigotine	5-HT₇ Receptor, Ki: 86 nM	5-HT_1A Receptor, Ki: 30 nM						Pan Agonist	99.98%
Asenapine	5-HT₇ Receptor, pKi: 9.9	5-HT_1A Receptor, pKi: 8.6 5-HT_1B Receptor, pKi: 8.4	5-HT_2A Receptor, pKi: 10.2 5-HT_2C Receptor, pKi: 10.5 5-HT_2B Receptor, pKi: 9.8		5-HT₅ Receptor, pKi: 8.8	5-HT₆ Receptor, pKi: 9.6		Pan Antagonist	98.81%
BRL 54443	5-HT₇ Receptor, Ki: >10,000 nM	5-HT_1E Receptor, Ki: 1.1 nM 5-HT_1F Receptor, Ki: 0.7 nM 5-HT_1A Receptor, Ki: 63 nM 5-HT_1B Receptor, Ki: 126 nM 5-HT_1D Receptor, Ki: 63 nM	5-HT_2A Receptor, Ki: 1259 nM 5-HT_2B Receptor, Ki: 100 nM 5-HT_2C Receptor, Ki: 316 nM			5-HT₆ Receptor, Ki: >10,000 nM		Pan Agonist	99.39%
Nuciferine	5-HT₇ Receptor, IC₅₀: 150 nM	5-HT_1A Receptor, EC₅₀: 3.2 μM	5-HT_2C Receptor, IC₅₀: 131 nM 5-HT_2A Receptor, IC₅₀: 478 nM 5-HT_2B Receptor, IC₅₀: 1 μM			5-HT₆ Receptor, EC₅₀: 700 nM		Pan Modulator	99.66%
Rotigotine Hydrochloride	5-HT₇ Receptor, Ki: 86 nM	5-HT_1A Receptor, Ki: 30 nM						Pan Agonist	≥95.0%
SEP-363856 hydrochloride	5-HT₇ Receptor, EC₅₀: 6.7 μM	5-HT_1A Receptor, EC₅₀: 2.3 μM 5-HT_1B Receptor, EC₅₀: 15.6 μM 5-HT_1D Receptor, EC₅₀: 0.262 μM	5-HT_2A Receptor, EC₅₀: >10 μM 5-HT_2C Receptor, EC₅₀: 30 μM					Pan Agonist	99.78%
GSK163090	Human 5-HT₇ Receptor , pKi: 6.8	5-HT_1A Receptor, pKi: 9.4 5-HT_1B Receptor, pKi: 8.5 5-HT_1D Receptor, pKi: 9.7	5-HT_2A Receptor, pKi: 6 5-HT_2B Receptor, pKi: 6.3 5-HT_2C Receptor, pKi: 5.8			Human 5-HT₆ Receptor, pKi: <5.3		Pan Antagonist	99.95%
Adoprazine	5-HT₇ Receptor, pKi: 7.2	5-HT_1A Receptor, pEC₅₀: 9 5-HT_1A Receptor, pKi: 9.1						Pan Agonist	98.10%
SB 271046 Hydrochloride	5-HT₇ Receptor, pKi: 5.39	5-HT_1D Receptor, pKi: 6.55 5-HT_1A Receptor, pKi: 6.35 5-HT_1B Receptor, pKi: 6.05 5-HT_1F Receptor, pKi: 5.95 5-HT_1E Receptor, pKi: <4.99	5-HT_2A Receptor, pKi: 5.62 5-HT_2B Receptor, pKi: 5.41 Human 5-HT_2C Receptor, pKi: 5.73			5-HT₆ Receptor, pKi: 8.92-9.02	5-HT₄ Receptor, pKi: 5.27	Pan Antagonist	98.64%
SB 243213 dihydrochloride	Human 5-HT₇ Receptor , pKi: 5.64	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₆ Receptor, pKi: 6.5		Pan Antagonist	≥99.0%
SB 243213 hydrochloride	Human 5-HT₇ Receptor , pKi: 5.64	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₆ Receptor, pKi: 6.5		Pan Antagonist
5-HT6/7 antagonist 1	5-HT₇ Receptor		5-HT_2A Receptor			5-HT₆ Receptor		Pan Antagonist
SEP-363856	5-HT₇ Receptor, EC₅₀: 6.7 μM	5-HT_1A Receptor, EC₅₀: 2.3 μM 5-HT_1B Receptor, EC₅₀: 15.6 μM 5-HT_1D Receptor, EC₅₀: 0.262 μM	5-HT_2A Receptor, EC₅₀: >10 μM 5-HT_2C Receptor, EC₅₀: 30 μM					Pan Agonist
SB 243213	Human 5-HT₇ Receptor , pKi: 5.64	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₆ Receptor, pKi: 6.5		Pan Antagonist	98.62%
ST1936 oxalate	Human 5-HT₇ Receptor , Ki: 168 nM		5-HT_2B Receptor, Ki: 245 nM			5-HT₆ Receptor, Ki: 13 nM		Pan Agonist
5-Carboxamidotryptamine maleate	5-HT₇ Receptor	5-HT_1A Receptor 5-HT_1B Receptor 5-HT_1D Receptor			5-HT₅ Receptor			Pan Agonist
AP521	5-HT₇ Receptor, IC₅₀: 198 nM (in rat)	5-HT_1A Receptor, IC₅₀: 94 nM (in human) 5-HT_1A Receptor, IC₅₀: 135 nM (in rat) 5-HT_1B Receptor, IC₅₀: 254 nM (in rat) 5-HT_1B Receptor, IC₅₀: 5530 nM (in human) 5-HT_1D Receptor, IC₅₀: 418 nM (in human)			5-HT_5A Receptor, IC₅₀: 422 nM (in human)			Pan Agonist
5-HT7 agonist 1	5-HT₇ Receptor							Pan Agonist
Brilaroxazine	5-HT₇ Receptor, Ki: 2.7 nM	5-HT_1A Receptor, Ki: 1.5 nM	5-HT_2A Receptor, Ki: 2.5 nM 5-HT_2B Receptor, Ki: 0.19 nM					Pan Modulator
Sarizotan	5-HT₇ Receptor, IC₅₀: 10 nM (human)	5-HT_1D Receptor, IC₅₀: 500 nM (calf) 5-HT_1A Receptor, IC₅₀: 6.5 nM (rat) 5-HT_1A Receptor, IC₅₀: 0.1 nM (human) 5-HT_1B Receptor, IC₅₀: 600 nM (rat)	5-HT_2A Receptor, IC₅₀: 960 nM (rat, agonist site) 5-HT_2A Receptor, IC₅₀: 587 nM (human, antagonist site) 5-HT_2C Receptor, IC₅₀: 800 nM (pig) 5-HT_2B Receptor, IC₅₀: 108 nM (human)	5-HT₃ Receptor, IC₅₀: 3500 nM (NG 108 cells)	5-HT_5A Receptor, IC₅₀: 313 nM (human)	5-HT₆ Receptor, IC₅₀: 3300 nM (human)		Pan Agonist
Iloperidone hydrochloride	Rat 5-HT₇ Receptor, Ki: 21.6 nM	Rat 5-HT_1A Receptor, Ki: 168 nM	Rat 5-HT₂ Receptor, Ki: 3.1 nM Human 5-HT_2A Receptor, Ki: 5.6 nM Human 5-HT_2C Receptor, Ki: 42.8 nM			Rat 5-HT₆ Receptor, Ki: 42.7 nM		Pan Antagonist

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5-HT7 Receptor Inhibitors

5-HT₇ Receptor Inhibitors