1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT7 Receptor Inhibitors

5-HT7 Receptor Inhibitors

5-HT1 Receptor

5-HT2 Receptor

5-HT3 Receptor

5-HT5 Receptor

5-HT6 Receptor

5-HT7 Receptor

5-HT Receptor

5-HT4 Receptor

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Sorry. There is currently no product that acts on isoform 5-HT7 Receptor together.

Please try each isoform separately.

5-HT7 Receptor Specific Inhibitors, Agonists, Antagonists & Modulators
Product Name 5-HT7 Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT4 Receptor 5-HT7 Receptor Selectivity Purity
SB-269970 hydrochloride
5-HT7 Receptor, pKi: 8.3
            Selective Antagonist 98.77%
Lurasidone
5-HT7 Receptor, IC50: 0.495 nM
5-HT1A Receptor, IC50: 6.75 nM
          Selective Modulator 99.49%
Asenapine maleate
5-HT7 Receptor, Ki: 0.13 nM
 
5-HT2A Receptor, Ki: 0.06 nM
5-HT2C Receptor, Ki: 0.03 nM
        Selective Antagonist 99.95%
Lurasidone Hydrochloride
5-HT7 Receptor, IC50: 0.495 nM
5-HT1A Receptor, IC50: 6.75 nM
          Selective Modulator 99.87%
SB 258719
5-HT7 Receptor, pKi: 7.5
            Selective Antagonist ≥99.0%
JNJ-18038683
Rat 5-HT7 Receptor, pKi: 8.19 (in HEK293 cells )
Human 5-HT7 Receptor , pKi: 8.20 (in HEK293 cells )
            Selective Antagonist 99.21%
Asenapine hydrochloride
5-HT7 Receptor, Ki: 0.13 nM
 
5-HT2A Receptor, Ki: 0.06 nM
5-HT2C Receptor, Ki: 0.03 nM
        Selective Antagonist 98.76%
SB-269970
Human 5-HT7 Receptor , pKi: 8.3
            Selective Antagonist
AS19
Human 5-HT7 Receptor , IC50: 0.83 nM
Human 5-HT7 Receptor , Ki: 0.6 nM
5-HT1A Receptor, Ki: 89.7 nM
5-HT1B Receptor, Ki: 490 nM
5-HT1D Receptor, Ki: 6.6 nM
   
5-HT5 Receptor, Ki: 98.5 nM
    Selective Agonist ≥99.0%
Methiothepin mesylate
5-HT7 Receptor, pKd: 8.99
5-HT1A Receptor, pKd: 7.10
5-HT1B Receptor, pKd: 7.28
5-HT1C Receptor, pKd: 7.56
5-HT1D Receptor, pKd: 6.99
5-HT2A Receptor, pKi: 8.50
5-HT2B Receptor, pKi: 8.68
5-HT2C Receptor, pKi: 8.35
 
5-HT5A Receptor, pKd: 7.0
5-HT5B Receptor, pKd: 7.8
5-HT6 Receptor, pKd: 8.74
  Pan Antagonist ≥98.0%
8-OH-DPAT
5-HT7 Receptor, Ki: 466 nM
5-HT1A Receptor, pIC50: 8.19
          Pan Agonist ≥98.0%
Vortioxetine hydrobromide
5-HT7 Receptor, Ki: 19 nM
   
5-HT3A Receptor, Ki: 3.7 nM
      Pan Inhibitor 99.94%
Vortioxetine
Human 5-HT7 Receptor , Ki: 19 nM
   
5-HT3A Receptor, Ki: 3.7 nM
      Pan Inhibitor 99.52%
LP-211
5-HT7 Receptor, Ki: 0.58 nM
5-HT1A Receptor, Ki: 188 nM
          Pan Agonist 99.61%
Nuciferine
5-HT7 Receptor, IC50: 150 nM
5-HT1A Receptor, EC50: 3.2 μM
5-HT2C Receptor, IC50: 131 nM
5-HT2A Receptor, IC50: 478 nM
5-HT2B Receptor, IC50: 1 μM
   
5-HT6 Receptor, EC50: 700 nM
  Pan Modulator 99.66%
SEP-363856 hydrochloride
5-HT7 Receptor, EC50: 6.7 μM
5-HT1A Receptor, EC50: 2.3 μM
5-HT1B Receptor, EC50: 15.6 μM
5-HT1D Receptor, EC50: 0.262 μM
5-HT2A Receptor, EC50: >10 μM
5-HT2C Receptor, EC50: 30 μM
        Pan Agonist 99.78%
Asenapine
5-HT7 Receptor, pKi: 9.9
5-HT1A Receptor, pKi: 8.6
5-HT1B Receptor, pKi: 8.4
5-HT2A Receptor, pKi: 10.2
5-HT2C Receptor, pKi: 10.5
5-HT2B Receptor, pKi: 9.8
 
5-HT5 Receptor, pKi: 8.8
5-HT6 Receptor, pKi: 9.6
  Pan Antagonist 98.81%
Metergoline
Human 5-HT7 Receptor , Ki: 16 nM
 
5-HT2A Receptor, pKi: 8.64
5-HT2B Receptor, pKi: 8.75
5-HT2C Receptor, pKi: 8.75
        Pan Antagonist 99.74%
Iloperidone
Rat 5-HT7 Receptor, Ki: 21.6 nM
Rat 5-HT1A Receptor, Ki: 168 nM
Rat 5-HT2 Receptor, Ki: 3.1 nM
Human 5-HT2A Receptor, Ki: 5.6 nM
Human 5-HT2C Receptor, Ki: 42.8 nM
   
Rat 5-HT6 Receptor, Ki: 42.7 μM
  Pan Antagonist 99.64%
BRL 54443
5-HT7 Receptor, Ki: >10,000 nM
5-HT1E Receptor, Ki: 1.1 nM
5-HT1F Receptor, Ki: 0.7 nM
5-HT1A Receptor, Ki: 63 nM
5-HT1B Receptor, Ki: 126 nM
5-HT1D Receptor, Ki: 63 nM
5-HT2A Receptor, Ki: 1259 nM
5-HT2B Receptor, Ki: 100 nM
5-HT2C Receptor, Ki: 316 nM
   
5-HT6 Receptor, Ki: >10,000 nM
  Pan Agonist 99.39%
Rotigotine
5-HT7 Receptor, Ki: 86 nM
5-HT1A Receptor, Ki: 30 nM
          Pan Agonist 99.98%
Rotigotine Hydrochloride
5-HT7 Receptor, Ki: 86 nM
5-HT1A Receptor, Ki: 30 nM
          Pan Agonist ≥95.0%
GSK163090
Human 5-HT7 Receptor , pKi: 6.8
5-HT1A Receptor, pKi: 9.4
5-HT1B Receptor, pKi: 8.5
5-HT1D Receptor, pKi: 9.7
5-HT2A Receptor, pKi: 6
5-HT2B Receptor, pKi: 6.3
5-HT2C Receptor, pKi: 5.8
   
Human 5-HT6 Receptor, pKi: <5.3
  Pan Antagonist 99.95%
SB 243213
Human 5-HT7 Receptor , pKi: 5.64
human 5-HT1A Receptor, pKi: <5.3
human 5-HT1B Receptor, pKi: 5.5
human 5-HT1D Receptor, pKi: 6.32
human 5-HT1E Receptor, pKi: <5.4
human 5-HT1F Receptor, pKi: 5.35
Human 5-HT2C Receptor, pKi: 9.37
Human 5-HT2A Receptor, pKi: 7.01
human 5-HT2B Receptor, pKi: 7.2
   
Human 5-HT6 Receptor, pKi: 6.5
  Pan Antagonist 98.62%
Adoprazine
5-HT7 Receptor, pKi: 7.2
5-HT1A Receptor, pEC50: 9
5-HT1A Receptor, pKi: 9.1
          Pan Agonist 98.10%
SB 271046 Hydrochloride
5-HT7 Receptor, pKi: 5.39
5-HT1D Receptor, pKi: 6.55
5-HT1A Receptor, pKi: 6.35
5-HT1B Receptor, pKi: 6.05
5-HT1F Receptor, pKi: 5.95
5-HT1E Receptor, pKi: <4.99
5-HT2A Receptor, pKi: 5.62
5-HT2B Receptor, pKi: 5.41
Human 5-HT2C Receptor, pKi: 5.73
   
5-HT6 Receptor, pKi: 8.92-9.02
5-HT4 Receptor, pKi: 5.27
Pan Antagonist 98.64%
SB 243213 dihydrochloride
Human 5-HT7 Receptor , pKi: 5.64
human 5-HT1A Receptor, pKi: <5.3
human 5-HT1B Receptor, pKi: 5.5
human 5-HT1D Receptor, pKi: 6.32
human 5-HT1E Receptor, pKi: <5.4
human 5-HT1F Receptor, pKi: 5.35
Human 5-HT2C Receptor, pKi: 9.37
Human 5-HT2A Receptor, pKi: 7.01
human 5-HT2B Receptor, pKi: 7.2
   
Human 5-HT6 Receptor, pKi: 6.5
  Pan Antagonist ≥99.0%
SB 243213 hydrochloride
Human 5-HT7 Receptor , pKi: 5.64
human 5-HT1A Receptor, pKi: <5.3
human 5-HT1B Receptor, pKi: 5.5
human 5-HT1D Receptor, pKi: 6.32
human 5-HT1E Receptor, pKi: <5.4
human 5-HT1F Receptor, pKi: 5.35
Human 5-HT2C Receptor, pKi: 9.37
Human 5-HT2A Receptor, pKi: 7.01
human 5-HT2B Receptor, pKi: 7.2
   
Human 5-HT6 Receptor, pKi: 6.5
  Pan Antagonist
5-Carboxamidotryptamine maleate
5-HT7 Receptor
5-HT1A Receptor
5-HT1B Receptor
5-HT1D Receptor
   
5-HT5 Receptor
    Pan Agonist ≥98.0%
5-HT6/7 antagonist 1
5-HT7 Receptor
 
5-HT2A Receptor
   
5-HT6 Receptor
  Pan Antagonist
SEP-363856
5-HT7 Receptor, EC50: 6.7 μM
5-HT1A Receptor, EC50: 2.3 μM
5-HT1B Receptor, EC50: 15.6 μM
5-HT1D Receptor, EC50: 0.262 μM
5-HT2A Receptor, EC50: >10 μM
5-HT2C Receptor, EC50: 30 μM
        Pan Agonist
ST1936 oxalate
Human 5-HT7 Receptor , Ki: 168 nM
 
5-HT2B Receptor, Ki: 245 nM
   
5-HT6 Receptor, Ki: 13 nM
  Pan Agonist
Repinotan
5-HT7 Receptor, Ki: 6 nM
5-HT1A Receptor, Ki: 0.19 nM (In calf hippocampus)
5-HT1A Receptor, Ki: 0.25 nM (In rat and human cortex)
5-HT1A Receptor, Ki: 0.59 nM (In rat hippocampus)
          Pan Agonist
AP521
5-HT7 Receptor, IC50: 198 nM (in rat)
5-HT1A Receptor, IC50: 94 nM (in human)
5-HT1A Receptor, IC50: 135 nM (in rat)
5-HT1B Receptor, IC50: 254 nM (in rat)
5-HT1B Receptor, IC50: 5530 nM (in human)
5-HT1D Receptor, IC50: 418 nM (in human)
   
5-HT5A Receptor, IC50: 422 nM (in human)
    Pan Agonist
5-HT7 agonist 1
5-HT7 Receptor
            Pan Agonist
Brilaroxazine
5-HT7 Receptor, Ki: 2.7 nM
5-HT1A Receptor, Ki: 1.5 nM
5-HT2A Receptor, Ki: 2.5 nM
5-HT2B Receptor, Ki: 0.19 nM
        Pan Modulator
Sarizotan
5-HT7 Receptor, IC50: 10 nM (human)
5-HT1D Receptor, IC50: 500 nM (calf)
5-HT1A Receptor, IC50: 6.5 nM (rat)
5-HT1A Receptor, IC50: 0.1 nM (human)
5-HT1B Receptor, IC50: 600 nM (rat)
5-HT2A Receptor, IC50: 960 nM (rat, agonist site)
5-HT2A Receptor, IC50: 587 nM (human, antagonist site)
5-HT2C Receptor, IC50: 800 nM (pig)
5-HT2B Receptor, IC50: 108 nM (human)
5-HT3 Receptor, IC50: 3500 nM (NG 108 cells)
5-HT5A Receptor, IC50: 313 nM (human)
5-HT6 Receptor, IC50: 3300 nM (human)
  Pan Agonist
Iloperidone hydrochloride
Rat 5-HT7 Receptor, Ki: 21.6 nM
Rat 5-HT1A Receptor, Ki: 168 nM
Rat 5-HT2 Receptor, Ki: 3.1 nM
Human 5-HT2A Receptor, Ki: 5.6 nM
Human 5-HT2C Receptor, Ki: 42.8 nM
   
Rat 5-HT6 Receptor, Ki: 42.7 nM
  Pan Antagonist