1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Serotonin Transporter
  3. Vortioxetine hydrobromide

Vortioxetine hydrobromide (Synonyms: Lu AA21004 hydrobromide)

Cat. No.: HY-15414A Purity: 99.91%
Handling Instructions

Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

For research use only. We do not sell to patients.

Vortioxetine hydrobromide Chemical Structure

Vortioxetine hydrobromide Chemical Structure

CAS No. : 960203-27-4

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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10 mg USD 55 In-stock
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50 mg USD 121 In-stock
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100 mg USD 165 In-stock
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200 mg USD 275 In-stock
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500 mg USD 495 In-stock
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1 g USD 715 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Vortioxetine hydrobromide:

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Vortioxetine hydrobromide

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

IC50 & Target

sPLA2

15 nM (Ki)

5-HT3A Receptor

3.7 nM (Ki)

5-HT7 Receptor

19 nM (Ki)

SERT

1.6 nM (Ki)

In Vitro

Vortioxetine (Compound 5m) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Vortioxetine displays antagonistic properties at 5-HT3A and 5-HT7 receptors, partial agonist properties at 5-HT1B receptors, agonistic properties at 5-HT1A receptors, and potent inhibition of SERT[1]. Vortioxetine is a partial h5-HT 1B receptor agonist with EC50 of 460 nM and intrinsic activity of 22% using a whole-cell cAMP-based assay. Vortioxetine binds to the r5-HT 7 receptor with a Ki value of 200 nM and is a functional antagonist at the r5-HT7 receptor with an IC50 of 2 μM in an in vitro whole-cell cAMP assay[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vortioxetine (Lu AA21004) occupies the r5-HT1B receptor and rSERT (ED50= 3.2 and 0.4 mg/kg, respectively) after subcutaneous administration and is a 5-HT3 receptor antagonist[6]. Vortioxetine significantly increases cell proliferation and cell survival and stimulates maturation of immature granule cells in the sub granular zone of the dentate gyrus of the hippocampus after 21 days of treatment[3]. Vortioxetine does not cause cognitive or psychomotor impairment[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

379.36

Formula

C18H23BrN2S

CAS No.
SMILES

CC1=CC=C(SC2=CC=CC=C2N3CCNCC3)C(C)=C1.[H]Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (131.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6360 mL 13.1801 mL 26.3602 mL
5 mM 0.5272 mL 2.6360 mL 5.2720 mL
10 mM 0.2636 mL 1.3180 mL 2.6360 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.91%

References
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Vortioxetine hydrobromide
Cat. No.:
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