1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT3 Receptor Inhibitors

5-HT3 Receptor Inhibitors

5-HT1 Receptor

5-HT2 Receptor

5-HT3 Receptor

5-HT5 Receptor

5-HT6 Receptor

5-HT7 Receptor

5-HT Receptor

5-HT4 Receptor

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Sorry. There is currently no product that acts on isoform 5-HT3 Receptor together.

Please try each isoform separately.

5-HT3 Receptor Specific Inhibitors, Agonists, Antagonists & Modulators
Product Name 5-HT3 Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT4 Receptor 5-HT3 Receptor Selectivity Purity
GTS-21 dihydrochloride
5-HT3A Receptor, IC50: 3.1 μM
            Selective Antagonist 99.78%
2-Methyl-5-HT
5-HT3 Receptor
            Selective Agonist 98.09%
Granisetron Hydrochloride
5-HT3 Receptor, IC50: 17 μM
            Selective Antagonist 99.86%
Azasetron hydrochloride
5-HT3 Receptor, IC50: 0.33 nM
            Selective Antagonist 99.75%
Tropisetron Hydrochloride
5-HT3 Receptor, IC50: 70.1 nM
            Selective Antagonist 99.95%
Pumosetrag Hydrochloride
5-HT3 Receptor
            Selective Agonist 99.77%
Tropisetron
5-HT3 Receptor, IC50: 70.1 nM
            Selective Antagonist ≥98.0%
Phenylbiguanide
5-HT3 Receptor, EC50: 3 μM
            Selective Agonist ≥98.0%
Bemesetron
5-HT3 Receptor, IC50: 0.33 nM
            Selective Antagonist ≥99.0%
Dolasetron
5-HT3 Receptor
            Selective Antagonist ≥98.0%
Ramosetron Hydrochloride
5-HT3 Receptor
            Selective Antagonist 99.91%
Granisetron
5-HT3 Receptor, IC50: 17 μM
            Selective Antagonist
Dolasetron Mesylate hydrate
5-HT3 Receptor
            Selective Antagonist ≥99.0%
2-Methyl-5-HT hydrochloride
5-HT3 Receptor
            Selective Agonist
(R)-Mirtazapine D3
5-HT3 Receptor
            Selective Antagonist
(R)-Mirtazapine
5-HT3 Receptor
            Selective Antagonist
A-582941 dihydrochloride
5-HT3 Receptor, Ki: 150 nM
            Selective Agonist
2-Methyl-5-HT maleate
5-HT3 Receptor
            Selective Agonist
Dolasetron Mesylate
5-HT3 Receptor
            Selective Antagonist
Pancopride
5-HT3 Receptor
            Selective Antagonist
RG-12915
5-HT3 Receptor, IC50: 0.16 nM
            Selective Antagonist
T 82
5-HT3 Receptor
            Selective Antagonist
Zatosetron maleate
5-HT3 Receptor
            Selective Antagonist
5-HT3 antagonist 1
5-HT3 Receptor
            Selective Antagonist
5-HT3 antagonist 3
5-HT3 Receptor, Ki: 0.25 nM
            Selective Antagonist
5-HT3-In-1
5-HT3 Receptor
            Selective Inhibitor
5-HT3 antagonist 2
5-HT3 Receptor
            Selective Antagonist
Olanzapine
5-HT3 Receptor, Ki: 57 nM
5-HT1 Receptor, Ki: 7 nM
5-HT2A Receptor, Ki: 4 nM
5-HT2C Receptor, Ki: 11 nM
 
5-HT6 Receptor, Ki: 5 nM
    Pan Antagonist 99.89%
Ondansetron
5-HT3 Receptor
            Pan Antagonist 99.41%
Mirtazapine
5-HT3 Receptor, pKi: 8.1
 
5-HT2 Receptor, pKi: 8.05
        Pan Antagonist 99.97%
Alosetron Hydrochloride
5-HT3 Receptor
            Pan Antagonist 99.79%
Palonosetron Hydrochloride
5-HT3 Receptor
            Pan Antagonist 99.96%
Vortioxetine hydrobromide
5-HT3A Receptor, Ki: 3.7 nM
       
5-HT7 Receptor, Ki: 19 nM
  Pan Inhibitor 99.94%
Vortioxetine
5-HT3A Receptor, Ki: 3.7 nM
       
Human 5-HT7 Receptor , Ki: 19 nM
  Pan Inhibitor 99.52%
RS-127445 hydrochloride
5-HT3 Receptor, pKi: <6
 
5-HT2A Receptor, pKi: 6.3
5-HT2C Receptor, pKi: 6.4
5-HT2B Receptor, pKi: 9.5
5-HT5 Receptor, pKi: <6
5-HT6 Receptor, pKi: <6
    Pan Antagonist 99.58%
Ondansetron hydrochloride dihydrate
5-HT3 Receptor
            Pan Antagonist 99.87%
Tedatioxetine hydrobromide
5-HT3 Receptor
 
5-HT2A Receptor
5-HT2C Receptor
        Pan Antagonist 99.98%
Talipexole dihydrochloride
5-HT3 Receptor
            Pan Antagonist 99.88%
Fabesetron
5-HT3 Receptor
         
5-HT4 Receptor
Pan Antagonist 95.72%
Cyamemazine
5-HT3 Receptor, Ki: 75 nM
 
5-HT2A Receptor, Ki: 1.5 nM
5-HT2C Receptor, Ki: 12 nM
        Pan Antagonist ≥99.0%
PU02
5-HT3A Receptor, IC50: 0.36 μM
5-HT 3 AB, IC50: 0.73 μM
            Pan Antagonist ≥99.0%
Facinicline hydrochloride
5-HT3 Receptor, Ki: 1.2 nM
            Pan Antagonist 99.93%
Alosetron
5-HT3 Receptor
            Pan Antagonist
Setiptiline
5-HT3 Receptor
 
5-HT2A Receptor
5-HT2C Receptor
        Pan Modulator 96.54%
Palonosetron
5-HT3 Receptor
            Pan Antagonist
Lintopride
5-HT3 Receptor
         
5-HT4 Receptor
Pan Antagonist 96.38%
(±)-Fabesetron hydrochloride
5-HT3 Receptor
         
5-HT4 Receptor
Pan Antagonist
Mirtazapine D3
5-HT3 Receptor
 
5-HT2 Receptor
        Pan Inhibitor
GR 113808
5-HT3 Receptor
5-HT1A Receptor
5-HT2A Receptor
5-HT2C Receptor
     
5-HT4 Receptor
Pan Antagonist
Sarizotan
5-HT3 Receptor, IC50: 3500 nM (NG 108 cells)
5-HT1D Receptor, IC50: 500 nM (calf)
5-HT1A Receptor, IC50: 6.5 nM (rat)
5-HT1A Receptor, IC50: 0.1 nM (human)
5-HT1B Receptor, IC50: 600 nM (rat)
5-HT2A Receptor, IC50: 960 nM (rat, agonist site)
5-HT2A Receptor, IC50: 587 nM (human, antagonist site)
5-HT2C Receptor, IC50: 800 nM (pig)
5-HT2B Receptor, IC50: 108 nM (human)
5-HT5A Receptor, IC50: 313 nM (human)
5-HT6 Receptor, IC50: 3300 nM (human)
5-HT7 Receptor, IC50: 10 nM (human)
  Pan Agonist
ML 10302 hydrochloride
5-HT3 Receptor, Ki: 782 nM
         
5-HT4 Receptor, EC50: 4 nM
5-HT4 Receptor, Ki: 1.07 nM
Pan Agonist
(S)-Mirtazapine
5-HT3 Receptor
 
5-HT2 Receptor
        Pan Antagonist
Alosetron ((Z)-2-butenedioate)
5-HT3 Receptor
            Pan Antagonist
Alosetron (Hydrochloride(1:X))
5-HT3 Receptor
            Pan Antagonist
Ondansetron hydrochloride
5-HT3 Receptor
            Pan Antagonist
Setiptiline maleate
5-HT3 Receptor
 
5-HT2A Receptor
5-HT2C Receptor
        Antagonist 98.18%