PSN09
PSN09 is a blood-brain barrier-permeable agonist of PSAM4-GlyR and PSAM4-5-HT3 receptors with high affinity. 18F-labeled PSN09 serves as a radiotracer for PET imaging in non-human primates.
For research use only. We do not sell to patients.
- Formula: C20H18FN3O
- Molecular Weight:335.37
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All 5-HT Receptor Isoforms
More
Biological Activity
|
5-HT3 Receptor |
PSN09 potently binds to PSAM4-GlyR in transfected HEK-293 cells, with a Ki of 1.86 nM[1].
PSN09 potently binds to PSAM4-5-HT3 in transfected HEK-293 cells, with a Ki value of 5.67 nM[1].
PSN09 (0.1-100 μM) potently activates PSAM4-GlyR in transfected HEK-293 cells, with an EC50 of 8.3 nM[1].
PSN09 (0.1-100 μM) potently activates PSAM4-5-HT3 in transduced HEK-293 cells, with an EC50 of 16.8 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Monkey transduced with PSAM4-GlyR (11-year-old male, Lenti-hSyn-PSAM4-GlyR injected into left amygdala)[1]
-
Dosage:1 mg/kg
-
Administration:i.v.; single dose; administered 10 minutes before [18F]FDG injection
-
Result:Did not significantly alter [18F]FDG arterial input functions.
Reduced MRGlu in the target transduced left amygdala by 19%, and decreased the target-to-mirror MRGlu ratio by 3%.
Chemical Information
-
Molecular Weight 335.37
-
Formula C20H18FN3O
-
SMILES
FC1=CC=C(C=C1)COC2=NC3=CC4=C(C5CNCC4C5)C=C3N=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz