ADAM12
ADAM12, or meltrin alpha, is unusual within the family because it exists as two splice variants: membrane-anchored ADAM12-L and secreted ADAM12-S. Both isoforms proteolyze insulin-like growth factor binding proteins, notably IGFBP-3 and IGFBP-5, modulating IGF bioavailability, and ADAM12-L has been implicated in shedding EGFR ligands and in muscle differentiation, the process from which its meltrin name derives. ADAM12-S is abundantly released from the placenta into maternal serum, where altered levels are associated with preeclampsia and fetal chromosomal abnormalities, making it a studied pregnancy biomarker. Expression is also prominent in muscle and remodeling stromal tissues, and ADAM12-L has been linked to cardiac hypertrophy in experimental models.
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ADAM12 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
