ADAM12 Protein, Human (HEK293, His, solution)

ADAM12 Protein significantly contributes to skeletal muscle regeneration, particularly in initiating cell fusion. Its multifaceted involvement extends to forming macrophage-derived giant cells (MGC) and differentiating osteoclasts from mononuclear precursors, showcasing a broader role beyond muscle regeneration. ADAM12 Protein, Human (HEK293, His, solution) is the recombinant human-derived ADAM12 protein, expressed by HEK293 , with C-10*His labeled tag.

ADAM12 protein plays a significant role in skeletal muscle regeneration, particularly during the initiation of cell fusion processes. Additionally, it is implicated in the formation of macrophage-derived giant cells (MGC) and the differentiation of osteoclasts from mononuclear precursors, highlighting its multifaceted involvement in cellular events beyond muscle regeneration.

Measured by its binding ability in a functional ELISA. Immobilized ADAM12 Protein, Human (HEK293, His) at 10 μg/mL (100 μl/well) can bind mouse FLRG-His with a linear range of 0.31-1.25 μg/mL.

Human

HEK293

C-10*His

O43184 (R29-S513)

8038

Partial

MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS

Approximately 27 kDa (Propeptide) & 55 kDa (Mature form) & 72 kDa (Pro form), based on SDS-PAGE under reducing conditions, due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.