Caspase
Caspases are a family of cysteine-aspartyl proteases that execute apoptosis and orchestrate inflammatory signaling by cleaving specifically after aspartate residues. Initiator caspases such as CASP8, CASP9, and CASP10 activate death receptor and mitochondrial pathways, while effector caspases CASP3, CASP6, and CASP7 dismantle the cell through hundreds of substrates. The inflammatory caspases CASP1, CASP4, and CASP5 (CASP11 in mice) process interleukin-1 beta and gasdermin D downstream of inflammasome activation. Dysregulated caspase activity underlies neurodegeneration, cancer, and inflammatory disease, and recombinant caspase proteins paired with fluorogenic substrates are standard tools for apoptosis assays and inhibitor screening.
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Caspase Protéines Recombinantes (10)
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Inhibitors & Agonists (1497)
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Voies de signalisation
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
