1. Metabolic Enzyme/Protease
  2. Cathepsin

Cathepsin

Cathepsins are proteases (enzymes that degrades proteins) found in all animals as well as other organisms. The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. Most of the members become activated at the low pH found in lysosomes. The activity of this family lies almost entirely within those organelles. Cathepsins have a vital role in mammalian cellular turnover, e.g. bone resorption. They degrade polypeptides and are distinguished by their substratespecificities. Classification: Cathepsin A, Cathepsin B, Cathepsin C, Cathepsin D, Cathepsin E, Cathepsin F, Cathepsin G, Cathepsin H, Cathepsin K, Cathepsin L1, Cathepsin L2, Cathepsin O, Cathepsin S, Cathepsin W, Cathepsin Z. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsins may also cleave some protein precursors, thereby releasing regulatory peptides.

Cathepsin Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-15282
    E-64 Inhibitor
    E-64 is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
  • HY-10042
    Odanacatib Inhibitor
    Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrates high selectivity versus off-target cathepsin B, L, S.
  • HY-P0018
    Pepstatin Inhibitor
    Pepstatin is a potent inhibitor of aspartyl proteases, and inhibits the aspartic proteases cathepsin D, pepsin, and renin.
  • HY-15533
    LY 3000328 Inhibitor
    Cathepsin S inhibitor is a potent and selective Cathepsin S (Cat S) inhibitor with IC50 of 7.7±5.85 nM and 1.67±1.17 nM for hCat S and mCat S.
  • HY-100229
    Aloxistatin Inhibitor
    Aloxistatin (E64d) is a broad-spectrum cell-permeable cysteine protease inhibitor.
  • HY-100350
    CA-074 methyl ester Inhibitor
    CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
  • HY-15958
    VBY-825 Inhibitor
    VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.
  • HY-18234A
    Leupeptin hemisulfate Inhibitor
    Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor, which has been shown to inhibit cathepsins B, H, L, and S, calpain, and trypsin.
  • HY-15100
    Balicatib Inhibitor
    Balicatib(AAE-581) is a potent and selective inhibitor of cathepsin K; 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.