1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Cathepsin

Cathepsin

Cathepsins are proteases (enzymes that degrades proteins) found in all animals as well as other organisms. The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. Most of the members become activated at the low pH found in lysosomes. The activity of this family lies almost entirely within those organelles. Cathepsins have a vital role in mammalian cellular turnover, e.g. bone resorption. They degrade polypeptides and are distinguished by their substratespecificities. Classification: Cathepsin A, Cathepsin B, Cathepsin C, Cathepsin D, Cathepsin E, Cathepsin F, Cathepsin G, Cathepsin H, Cathepsin K, Cathepsin L1, Cathepsin L2, Cathepsin O, Cathepsin S, Cathepsin W, Cathepsin Z. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsins may also cleave some protein precursors, thereby releasing regulatory peptides.

Cathepsin Related Products (23):

Cat. No. Product Name Effect Purity
  • HY-18234A
    Leupeptin hemisulfate Inhibitor >98.0%
    Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor.
  • HY-B0496
    PMSF Inhibitor >99.0%
    PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates.
  • HY-100229
    Aloxistatin Inhibitor 98.22%
    Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor.
  • HY-15282
    E-64 Inhibitor 99.62%
    E-64 is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
  • HY-100350
    CA-074 methyl ester Inhibitor 98.40%
    CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
  • HY-100223
    Calpeptin Inhibitor >98.0%
    Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets. Calpeptin is also an inhibitor of cathepsin K.
  • HY-D0843
    N-Ethylmaleimide Inhibitor
    N-Ethylmaleimide (NEM) is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria.
  • HY-109069
    Petesicatib Inhibitor
    Petesicatib is a cathepsin S inhibitor, used in research of immune diseases.
  • HY-15533
    LY 3000328 Inhibitor 99.35%
    LY 3000328 is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively.
  • HY-103350
    CA-074 Inhibitor 99.85%
    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
  • HY-10042
    Odanacatib Inhibitor 99.80%
    Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC50 of 0.2 nM for human cathepsin K.
  • HY-P1645
    Papain
    Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.
  • HY-15958
    VBY-825 Inhibitor
    VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.
  • HY-15100
    Balicatib Inhibitor
    Balicatib(AAE-581) is a potent and selective inhibitor of cathepsin K; 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.
  • HY-17541
    Cysteine Protease inhibitor Inhibitor
    Cysteine Protease inhibitor is an inhibitor of cysteine protease.
  • HY-17541A
    Cysteine Protease inhibitor hydrochloride Inhibitor
    Cysteine Protease inhibitor hydrochloride is an inhibitor of cysteine protease.
  • HY-112818
    S130 Inhibitor
    S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 µM. S130 suppresses autophagy flux.
  • HY-125169
    NSC 185058 Inhibitor
    NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. NSC185058 markedly attenuates autophagic activity.
  • HY-100227
    E 64c Inhibitor
    E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor.
  • HY-112583
    MIV-247 Inhibitor
    MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
Isoform Specific Products

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