NOTA-FZCD-3
NOTA-FZCD-3 is a NOTA (HY-134418)-labeled FZCD-3 polypeptide precursor that targets cathepsin D (CTSD) with a KD of 0.65 μM. NOTA-FZCD-3 binds specifically to the active site of CTSD, exhibits rapid in vivo clearance properties, and remains stable in blood for more than 2 h. NOTA-FZCD-3 can be used in studies monitoring CTSD-positive tumors.
For research use only. We do not sell to patients.
- Formula: C59H107N11O18
- Molecular Weight:1258.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cathepsin D 0.65 μM (Kd) |
[68Ga]Ga-NOTA-FZCD-3 (0.5-2 h; 37°C) remains stable for at least 2 hours at 37°C in normal saline and human serum, with no decomposition detected[1].
[68Ga]Ga-NOTA-FZCD-3 (0.5-2 h) is taken up by human breast cancer cell lines MCF-7, MDA-MB-468, MDA-MB-415 and MDA-MB-175VII in a time-dependent manner. The uptake level is directly correlated with endogenous CTSD expression, and a peak uptake rate of 1.45% is observed in MDA-MB-175VII cells at 1 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[68Ga]Ga-NOTA-FZCD-3 (2.5-7.4 MBq; intravenous injection; single administration) exhibits the highest tumor uptake rate and contrast in the MDA-MB-175VII breast cancer xenograft model, with a peak tumor-to-non-tissue ratio of 7.65 at 1 h post-injection[1].
[68Ga]Ga-NOTA-FZCD-3 (3.7-7.4 MBq; intravenous injection; single dose) achieves specific tumor uptake in A549 lung cancer xenografts, with an initial uptake of 2.47% ID/g at 0.5 h post-injection[1].
The uptake of [68Ga]Ga-NOTA-FZCD-3 (2.5-3.7 MBq; intravenous injection; single administration) in MDA-MB-175VII tumor xenografts is directly correlated with endogenous CTSD expression levels[1].
[68Ga]Ga-NOTA-FZCD-3 (intravenous injection; single dose) exhibits favorable biosafety in tumor-bearing BALB/c nude mice, with no organ toxicity detected 7 days post-injection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1258.54
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Formula C59H107N11O18
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Sequence
Isovaleryl-Val-Thr-Leu-Thr-Leu-Lys-NOTA
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Sequence Shortening
Isovaleryl‑VTLTLK-NOTA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOTA-FZCD-3 Related Classifications
HY-P11844 Related Classifications
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